Register | Sign In


Understanding through Discussion


EvC Forum active members: 66 (9164 total)
5 online now:
Newest Member: ChatGPT
Post Volume: Total: 916,476 Year: 3,733/9,624 Month: 604/974 Week: 217/276 Day: 57/34 Hour: 3/2


Thread  Details

Email This Thread
Newer Topic | Older Topic
  
Author Topic:   Transposons & Shared Endogenous Retrovirus's
derwood
Member (Idle past 1898 days)
Posts: 1457
Joined: 12-27-2001


Message 31 of 40 (11272)
06-10-2002 6:32 PM


Perused the paper, found it wanting.
Just another 'what are the chances of cytochrome c forming spontaneously in its extant amino acid order... blah ... blah...'
Works wonders on the masses, I'm sure...

Replies to this message:
 Message 32 by Tranquility Base, posted 06-11-2002 2:21 AM derwood has not replied

  
Tranquility Base
Inactive Member


Message 32 of 40 (11282)
06-11-2002 2:21 AM
Reply to: Message 31 by derwood
06-10-2002 6:32 PM


SLPx, on the creationist paper I'm a structural biologist so I'm quite cautious about attempts to identify the chances of coming up with a protein for a specific job. There might be 10 different protein folds which could equally well act as scaffolds, not to mention billions of possible seqeunces. We actually just don't know the answers to these questons. I felt these creationists (who I think are PhDed molecular biologists) did a good job tackling a difficult problem but I'll reserve judgment until I profesionally study it again.
Like I said earlier I'm yet to find a good mainstream paper which addresses this important issue (I'm sure some attempt has been made). Because evolutionists 'know' that it happened your side sometimes doesn't worry about the fact that some of the things you propose might actually be impossible! And guess what - we do the same! But I'll readily admit I don't know whether or not acclerated decay can account in detail for the radioisostopic data or rapid continental drift.
PS - tell me about the CRSQ baraminology papers by Robinson and Cavanaugh.
[This message has been edited by Tranquility Base, 06-11-2002]

This message is a reply to:
 Message 31 by derwood, posted 06-10-2002 6:32 PM derwood has not replied

  
peter borger
Member (Idle past 7687 days)
Posts: 965
From: australia
Joined: 07-05-2002


Message 33 of 40 (13338)
07-11-2002 4:23 AM
Reply to: Message 1 by TrueCreation
05-20-2002 10:47 PM


You say that
"I thought I would get some discussion on this topic of genetic evidence for ancestry. Tranquility and Taz I believe are in this type of field, or would know alot about It I would think.
Basically the claim for shared Retrovirus's is that because they are only passed on by inheritance. So if two organisms have the exact same ERV, in the exact same place, it's evidence they had a common ancestor. And chimps and people have five of them (or is it seven?)."
In the evolutionary community the shared retroviruses are commonly regarded as evidence of common descent. However, this may only be superficial.
First there is the claim that they do not serve any purpose. That should be scientifically proven. Maybe their function cannot be deduced from knocking them out, but that does not say anything about their function, since you can knock out genes with an open reading frame without any effect on the organism (genetic redundancies). Secondly, I would like to see the complete DNA sequences within the species and between the species before jumping to conclusions.
I checked one claim about the GLO gene (the gene that catalyses the final step in vitamin c synthesis) that has been inactivated in the same spot in primates and is taken as proof for common ancestry. And, indeed a superficial look would immediately convince any evolutionist. However, if you have a careful look at the sequence you will discover that the replacement of nucleotides is not at random between the distinct species. Secondly, you will discover that it does not make a difference for the mutation rate of this gene whether it is functional or not, in contrast to what evolution theory would predict. Thirdly, it violated population genetics: why would the inactivated gene become fixed in the entire population, while the active gene conveys longivity. In addition, evolution never compensated for vitamin C uptake in the gut, and, finally, the gene is redundant anyway since the third step in vit c synthesis already yields vitamin C by spontenaous oxidation. Also not unimportant, at least 2 primates are able to synthesise vitamin c in the liver, indicating the presence of an intact GLO gene (I once had a discussion about this gene with Dr D. Theobald (Talk Origin) so I know a bit about pseudogenes. However, at this level it is mostly speculation since we do not know a lot about it, yet).
In analogy to vestiges (appendix, tonsils) that shouldn't have a function according to evolution theory, it is far too early to say that this is proof for common descent. Show me the DNA sequences of these retroviruses in chimp and man, and I will respond in more detail.
Retrotransposons may have a function in epigenic regulation of gene expression (actually there is some proof for that. See: Dr. E. Max's website Talk Origin. Another one regulates the aghouti colour of fur in mice). It is thought that they may also play a role in eye colour (human), and some diseases like schizophrenia, and B.-W.-syndrome.
Evolutionists are free to claim these genes as evidence for common descent (as they did -- and still do -- for genetic redundancies, but which has actually contributed to the fall of natural selection as I will substantiate with scientific evidence in my posting as soon as Mark and Peter reply to my challenge). I foresee that ultimately there will be an unforeseen solution to these "vestiges".
Furthermore, read Spetner's book carefully on what he has to say on transposons. It makes sense. It will pay off to read opposite opinions. In summary, it is not an argument to take DNA sequences of which we do not know the function of as evidence for evolution. Our lack of knowledge ascribed 98% of the DNA in the genome as "junk". This vision is increasingly proven to be wrong.
Best Wishes
peter
[This message has been edited by peter borger, 07-11-2002]

This message is a reply to:
 Message 1 by TrueCreation, posted 05-20-2002 10:47 PM TrueCreation has not replied

Replies to this message:
 Message 36 by mark24, posted 07-11-2002 10:31 AM peter borger has replied

  
blitz77
Inactive Member


Message 34 of 40 (13344)
07-11-2002 6:30 AM
Reply to: Message 27 by Dr_Tazimus_maximus
05-31-2002 5:29 PM


[QUOTE]Originally posted by Dr_Tazimus_maximus:
Please explain to me or give me a reference how a global flood could deposit the species in a temporal fashion, ie no trilobites with sabertooth tigers; OK, bad example but I think you know what I mean. How about giant sloths and corytheosaurus, or mastadons and Allosaurus, ect.
[/B][/QUOTE]
What do you think paraconformities are? A paraconformity is what a evolutionary geologist calls for fossil systems out of order, but with no evidence of erosion or overthrusting. Paraconformities and other unconformities are what you learn about in geology in university.
[This message has been edited by blitz77, 07-11-2002]

This message is a reply to:
 Message 27 by Dr_Tazimus_maximus, posted 05-31-2002 5:29 PM Dr_Tazimus_maximus has not replied

Replies to this message:
 Message 35 by gene90, posted 07-11-2002 10:21 AM blitz77 has not replied

  
gene90
Member (Idle past 3845 days)
Posts: 1610
Joined: 12-25-2000


Message 35 of 40 (13355)
07-11-2002 10:21 AM
Reply to: Message 34 by blitz77
07-11-2002 6:30 AM


[QUOTE][b]What do you think paraconformities are?[/QUOTE]
[/b]
Unconformities due to non-deposition...
[QUOTE][b]A paraconformity is what a evolutionary geologist calls for fossil systems out of order[/QUOTE]
[/b]
Dr_Taz was asking for trilobites and saber-toothed cats in the same beds, not in two nearby beds.
You are also incorrect on another point, paraconformities are not regions of fossils out of order, they are systems in which a bed is missing.
[This message has been edited by gene90, 07-11-2002]

This message is a reply to:
 Message 34 by blitz77, posted 07-11-2002 6:30 AM blitz77 has not replied

  
mark24
Member (Idle past 5217 days)
Posts: 3857
From: UK
Joined: 12-01-2001


Message 36 of 40 (13356)
07-11-2002 10:31 AM
Reply to: Message 33 by peter borger
07-11-2002 4:23 AM


quote:
Originally posted by peter borger:

In the evolutionary community the shared retroviruses are commonly regarded as evidence of common descent. However, this may only be superficial.
First there is the claim that they do not serve any purpose. That should be scientifically proven. Maybe their function cannot be deduced from knocking them out, but that does not say anything about their function, since you can knock out genes with an open reading frame without any effect on the organism (genetic redundancies). Secondly, I would like to see the complete DNA sequences within the species and between the species before jumping to conclusions.
[This message has been edited by peter borger, 07-11-2002]

1/ What does ERVs having function have to do with them not being evidence of common descent?
2/ The complete genome doesn't need to be known for humans & chimps, for it to be known that there are 5 homologue ERVs common to them.
Mark
------------------
Occam's razor is not for shaving with.

This message is a reply to:
 Message 33 by peter borger, posted 07-11-2002 4:23 AM peter borger has replied

Replies to this message:
 Message 40 by peter borger, posted 07-14-2002 11:01 PM mark24 has not replied

  
peter borger
Member (Idle past 7687 days)
Posts: 965
From: australia
Joined: 07-05-2002


Message 37 of 40 (13391)
07-11-2002 11:50 PM
Reply to: Message 3 by Quetzal
05-21-2002 8:26 AM


Dear Quetzal,
In the evolutionary community the shared retroviruses are commonly regarded as evidence of common descent. However, this may only be superficial.
First there is the claim that they do not serve any purpose. That should be scientifically proven. Maybe their function cannot be deduced from knocking them out, but that does not say anything about their function, since you can knock out genes with an open reading frame without any effect on the organism (genetic redundancies). Secondly, I would like to see the complete DNA sequences within the species and between the species before jumping to conclusions.
I checked one claim about the GLO gene (the gene that catalyses the final step in vitamin c synthesis) that has been inactivated in the same spot in primates and is taken as proof for common ancestry. And, indeed a superficial look would immediately convince any evolutionist. However, if you have a careful look at the sequence you will discover that the replacement of nucleotides is not at random between the distinct species. Secondly, you will discover that it does not make a difference for the mutation rate of this gene whether it is functional or not, in contrast to what evolution theory would predict. Thirdly, it violates population genetics: why would the inactivated gene become fixed in the entire population, while the active gene conveys longivity. In addition, evolution never compensated for vitamin C uptake in the gut, and, finally, the gene is redundant anyway since the third step in vit c synthesis already yields vitamin C by spontenaous oxidation. Also not unimportant, at least 2 primates are able to synthesise vitamin c in the liver, indicating the presence of an intact GLO gene (I once had a discussion about this gene with Dr D. Theobald (Talk Origin) so I know a bit about pseudogenes. However, at this level it is mostly speculation since we do not know a lot about it, yet).
In analogy to vestiges (appendix, tonsils) that shouldn't have a function according to evolution theory, it is far too early to say that this is proof for common descent. Show me the DNA sequences of these retroviruses in chimp and man, and I will respond in more detail.
Retrotransposons may have a function in epigenic regulation of gene expression (actually there is some proof for that. See: Dr. E. Max's website Talk Origin. Another one regulates the aghouti colour of fur in mice). It is thought that they may also play a role in eye colour (human), and some diseases like schizophrenia, and B.-W.-syndrome.
Evolutionists are free to claim these genes as evidence for common descent (as they did -- and still do -- for genetic redundancies, but which has actually contributed to the fall of natural selection as I will substantiate with scientific evidence in my posting as soon as Mark and Peter reply to my challenge). I foresee that ultimately there will be an unforeseen solution to these "vestiges".
Furthermore, read Spetner's book carefully on what he has to say on transposons. It makes sense. It will pay off to read opposite opinions. In summary, it is not an argument to take DNA sequences of which we do not know the function of as evidence for evolution. Our lack of knowledge ascribed 98% of the DNA in the genome as "junk". This vision is increasingly proven to be wrong.
Best Wishes
peter

This message is a reply to:
 Message 3 by Quetzal, posted 05-21-2002 8:26 AM Quetzal has not replied

  
peter borger
Member (Idle past 7687 days)
Posts: 965
From: australia
Joined: 07-05-2002


Message 38 of 40 (13392)
07-12-2002 12:09 AM
Reply to: Message 6 by mark24
05-27-2002 12:42 PM


Dear Mark,
In the evolutionary community the shared retroviruses are commonly regarded as evidence of common descent. However, this may only be superficial.
First there is the claim that they do not serve any purpose. That should be scientifically proven. Maybe their function cannot be deduced from knocking them out, but that does not say anything about their function, since you can knock out genes with an open reading frame without any effect on the organism (genetic redundancies). Secondly, I would like to see the complete DNA sequences within the species and between the species before jumping to conclusions.
I checked one claim about the GLO pseudogene (the gene that catalyses the final step in vitamin c synthesis) that has been inactivated in the same spot in primates and is taken as proof for common ancestry. And, indeed a superficial look would immediately convince any evolutionist. However, if you have a careful look at the presented sequences you will discover that the replacement of nucleotides is not at random between the distinct species. Secondly, you will discover that it does not make a difference for the mutation rate of this gene whether it is functional or not, in contrast to what evolution theory would predict. Thirdly, it violates population genetics: why would the inactivated gene become fixed in the entire population, while the active gene conveys longivity. In addition, evolution never compensated for vitamin C uptake in the gut, and, finally, the gene is redundant anyway since the third step in vit c synthesis already yields vitamin C by spontenaous oxidation and is sufficient to avoid vit c deficiency. Also not unimportant, at least 2 primates are able to synthesise vitamin c in the liver, indicating the presence of an intact GLO gene (I once had a discussion about this gene with Dr D. Theobald (Talk Origin) so I know a bit about pseudogenes).
However, at this level it is mostly speculation since we do not know a lot about it, yet.
In analogy to vestiges (appendix, tonsils) that shouldn't have a function according to evolution theory, it is far too early to say that this is proof for common descent. Show me the DNA sequences of these retroviruses in chimp and man, and I will respond in more detail.
Retrotransposons may have a function in epigenic regulation of gene expression (actually there is some proof for that. See: Dr. E. Max's website Talk Origin. Another one regulates the aghouti colour of fur in mice). It is thought that they may also play a role in eye colour (human), and some diseases like schizophrenia, and B.-W.-syndrome.
Evolutionists are free to claim these genes as evidence for common descent (as they did -- and still do -- for genetic redundancies, but which has actually contributed to the fall of natural selection as I will substantiate with scientific evidence in my forthcoming posting on genetic redundancy).
I foresee that ultimately there will be an unexpected (regulatory or stabilizing) function for these "vestiges".
Furthermore, read Spetner's book carefully on what he has to say on transposons. It makes sense. It will pay off to read opposite opinions. In summary, it is not an argument to take DNA sequences of which we do not know the function of as evidence for evolution. Our lack of knowledge described 98% of the DNA in the genome as "junk". This vision is increasingly proven to be wrong.
Best Wishes
peter

This message is a reply to:
 Message 6 by mark24, posted 05-27-2002 12:42 PM mark24 has replied

Replies to this message:
 Message 39 by mark24, posted 07-12-2002 5:13 AM peter borger has not replied

  
mark24
Member (Idle past 5217 days)
Posts: 3857
From: UK
Joined: 12-01-2001


Message 39 of 40 (13406)
07-12-2002 5:13 AM
Reply to: Message 38 by peter borger
07-12-2002 12:09 AM


Perter B,
Message 36 please. I'm not claiming pseudogenes & transposons have no function.
Mark
------------------
Occam's razor is not for shaving with.

This message is a reply to:
 Message 38 by peter borger, posted 07-12-2002 12:09 AM peter borger has not replied

  
peter borger
Member (Idle past 7687 days)
Posts: 965
From: australia
Joined: 07-05-2002


Message 40 of 40 (13524)
07-14-2002 11:01 PM
Reply to: Message 36 by mark24
07-11-2002 10:31 AM


Dear mark,
Maybe these EVR's played a role in speciation, genome stability or regulation of species specific traits. I would turn it upside down. It is more likely that the EVR's we see today have been derived from the EVR's present in the human and chimp.
Where do you think viruses have their origin (since they do not spontaneously drop out of the sky)? In the genome, of course! There are plenty of viruses that have genes in there info-carriers that can be immediately traced back into human or other genomes.
Peter

This message is a reply to:
 Message 36 by mark24, posted 07-11-2002 10:31 AM mark24 has not replied

  
Newer Topic | Older Topic
Jump to:


Copyright 2001-2023 by EvC Forum, All Rights Reserved

™ Version 4.2
Innovative software from Qwixotic © 2024