High-Fructose Corn Syrup - the Controversy

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Obviously the question isn't "is HFCS bad for you", the question is "is HFCS worse than sucrose"? That's the notion driving the anti-HFCS crusade and the popularity of things like "Pepsi Throwback", the sweetened-with-sucrose version of Pepsi.

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Changing out HFCS for sucrose isn't any "better" for us from what I can tell.
High Fructose Corn Syrup: Tasty Toxin or Slandered Sweetener?I think the issue for some is that HFCS was in foods we wouldn't expect to find sugar. Foods with HFCS
Hard to moderate when it isn't just in the treats. I even found it in molasses.The difference I found so far is where sucrose and HFCS are metabolized by the body. Sucrose MetabolismFructoseHopefully the chemists can give us a clearer difference, if any.

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Recall that fructose, or "fruit sugar", is the primary sugar in fruits so shouldn't fruits make you fat?

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Have you ever heard of someone getting fat from fruit? Getting diabetic from fruit? Me neither.

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That's the mystery, I guess; according to the food scare crowd, fructose (fruit) is ok, and fructose+glucose (sucrose) is ok, and glucose is ok, but 55% fructose/43% glucose gives you instant diabetes.

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Taq covered that in Message 13. Fructose MetabolismThe article goes on to explain that a piece of fruit contains only 5-8 grams of fructose. We don't tend to accumulate the same volume of fructose by just eating whole fruits as we do when we consume sodas, fruit juices, and foods containing fructose. No webpage found at provided URL: Fructose - Sweet But DangeriousSo the volume is more the issue. Imagine eating enough whole fruit to equal 62 grams of fructose and then eat a meal with it.

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But not worse than sucrose.

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Right?

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Not if we're just talking about fructose it seems. If we get specially into HFCS as the experiment you noted in the OP, there does seem to be a difference when consuming HFCS and sucrose. I haven't found anything on just fructose (not HFCS) vs sucrose.Concerning HFCS, I found this article and I'm not a chemist so I can't really comment on anything from that standpoint. Looking at the results something is different between those two specific sugars. A sweet problem: Princeton researchers find that high-fructose corn syrup prompts considerably more weight gainSo I guess the question is does the imbalanced ratio make a difference to our bodies?
How are the higher saccharides metabolized by our bodies?
Does the "extra step" fructose has to endure when ingested as sucrose make a difference in how the body responds to it?
Is it the combination of all the above that causes our bodies to react differently to HFCS than sucrose when it comes to weight gain?From the tests there does seem to be a difference whether we understand it totally or not. I haven't been able to find anything on the larger sugar molecules called higher saccharides. At least nothing I can understand anyway.The rats tested reacted differently. They still seem to be searching for the why.