If God personally corrupted us to make us sinful, this creates a logical paradox with his indignation and sorrow of the corruption of mankind
All of God's punishments result in logical paradoxes if you assume he created everything and is omniscient and omnipotent. This hasn't stopped people from clinging to this explanation thus far, so I don't see how one more mountain of evidence in the mountain range we already have is going to change that.
The ''soul'' is powerless to do anything about this.
That may be entirely true. Again, I'm not a dualist, but you can consider the soul to be like a game cartridge and the brain is the game console. You can damage the console such that parts or all of the game don't work, so that scrambled images appear on the TV, but that doesn't mean the cartridge is broken or at fault.
True, this means the soul has very little influence to control things...but that's true of humans in general, so I don't see how this would be an insurmountable obstacle no matter what we find out about the brain for people committed to this idea.
You can't really 100% disprove the soul by definition, but it can be make extremely unlikely.
The soul is extremely unlikely because there has never been a need to invoke one to explain anything. The fact that people have done so, and continue to do so means that they will likely continue to do so, regardless of what is found. They will either redefine soul to fit into the increasingly shrinking gaps in knowledge, or they will simply admit that they don't understand how it all fits together but that they believe it does anyways.
Thi second approach is the most honest way to keep a faith in something supernatural for which there is absolutely no need or evidence.