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Author Topic:   Alzheimers cure?
RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 1 of 13 (755027)
04-03-2015 9:39 AM


Possibly
quote:
New Alzheimer’s treatment fully restores memory function
Of the mice that received the treatment, 75 percent got their memory functions back.
Australian researchers have come up with a non-invasive ultrasound technology that clears the brain of neurotoxic amyloid plaques - structures that are responsible for memory loss and a decline in cognitive function in Alzheimer’s patients.
If a person has Alzheimer’s disease, it’s usually the result of a build-up of two types of lesions - amyloid plaques, and neurofibrillary tangles. Amyloid plaques sit between the neurons and end up as dense clusters of beta-amyloid molecules, a sticky type of protein that clumps together and forms plaques.
Neurofibrillary tangles are found inside the neurons of the brain, and they’re caused by defective tau proteins that clump up into a thick, insoluble mass. This causes tiny filaments called microtubules to get all twisted, which disrupts the transportation of essential materials such as nutrients and organelles along them, just like when you twist up the vacuum cleaner tube.
Publishing in Science Translational Medicine, the team describes the technique as using a particular type of ultrasound called a focused therapeutic ultrasound, which non-invasively beams sound waves into the brain tissue. By oscillating super-fast, these sound waves are able to gently open up the blood-brain barrier, which is a layer that protects the brain against bacteria, and stimulate the brain’s microglial cells to activate. Microglila cells are basically waste-removal cells, so they’re able to clear out the toxic beta-amyloid clumps that are responsible for the worst symptoms of Alzheimer’s.
The team reports fully restoring the memory function of 75 percent of the mice they tested it on, with zero damage to the surrounding brain tissue. ...
Could be good news. May also open up a new technique for getting medicines past the blood-brain barrier.
Interesting to see how this research hold up in further testing.
Enjoy
Edited by RAZD, : quote

we are limited in our ability to understand
by our ability to understand
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AdminNosy
Administrator
Posts: 4754
From: Vancouver, BC, Canada
Joined: 11-11-2003


Message 2 of 13 (755028)
04-03-2015 10:09 AM
Reply to: Message 1 by RAZD
04-03-2015 9:39 AM


From one old man....
This is very good to hear. But I have an understanding that the plaques are not always associated with Alzheimer's.

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AdminNosy
Administrator
Posts: 4754
From: Vancouver, BC, Canada
Joined: 11-11-2003


(1)
Message 3 of 13 (755030)
04-03-2015 2:44 PM


Thread Copied from Proposed New Topics Forum
Thread copied here from the Alzheimers cure? thread in the Proposed New Topics forum.

  
xongsmith
Member
Posts: 2578
From: massachusetts US
Joined: 01-01-2009
Member Rating: 6.8


Message 4 of 13 (755045)
04-03-2015 4:56 PM
Reply to: Message 1 by RAZD
04-03-2015 9:39 AM


...wondering if the reports of certain kinds of memory loss patients responding to music is related???

- xongsmith, 5.7d

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coffee_addict
Member (Idle past 477 days)
Posts: 3645
From: Indianapolis, IN
Joined: 03-29-2004


Message 5 of 13 (755055)
04-03-2015 9:32 PM


Um... you people ever seen the movie I am Legend?

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Theodoric
Member
Posts: 9076
From: Northwest, WI, USA
Joined: 08-15-2005
Member Rating: 3.7


(1)
Message 6 of 13 (755056)
04-03-2015 9:37 PM
Reply to: Message 5 by coffee_addict
04-03-2015 9:32 PM


Terrible movie compared to the novella. It changed the whole premise and meaning of the book and title.

Facts don't lie or have an agenda. Facts are just facts
"God did it" is not an argument. It is an excuse for intellectual laziness.

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ramoss
Member (Idle past 612 days)
Posts: 3228
Joined: 08-11-2004


Message 7 of 13 (755058)
04-03-2015 10:00 PM
Reply to: Message 1 by RAZD
04-03-2015 9:39 AM


This looks like , if it holds up more complicated brains, good symptomatic relief. I would not call it a cure, but it will at least hold a lot of the ravages against the brain at bay.

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coffee_addict
Member (Idle past 477 days)
Posts: 3645
From: Indianapolis, IN
Joined: 03-29-2004


Message 8 of 13 (755059)
04-03-2015 10:02 PM
Reply to: Message 6 by Theodoric
04-03-2015 9:37 PM


Today, it's a cure for whatever. Tomorrow, we're all zombies.

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Tanypteryx
Member
Posts: 4344
From: Oregon, USA
Joined: 08-27-2006
Member Rating: 5.9


(4)
Message 9 of 13 (755061)
04-03-2015 10:27 PM
Reply to: Message 1 by RAZD
04-03-2015 9:39 AM


I took care of both of my parents for the last couple years of their lives. My mom had Alzheimer's and watching what it did to her and Dad was awful. He passed away 4 months after she did and I cannot say I was sorry when they were gone. I miss them, but I celebrate that they had 69 years of love and marriage.
I lost them both in 2012.
Every time I have trouble remembering things, like scientific names, I wonder if it is the early stages.
I would volunteer to take the treatment in a second.
I am a cancer survivor, but I can say without any hesitation that I would rather die from cancer than dementia.

What if Eleanor Roosevelt had wings? -- Monty Python
One important characteristic of a theory is that is has survived repeated attempts to falsify it. Contrary to your understanding, all available evidence confirms it. --Subbie
If evolution is shown to be false, it will be at the hands of things that are true, not made up. --percy

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RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


(2)
Message 10 of 13 (755068)
04-04-2015 8:31 AM
Reply to: Message 9 by Tanypteryx
04-03-2015 10:27 PM


I took care of both of my parents for the last couple years of their lives. My mom had Alzheimer's and watching what it did to her and Dad was awful. He passed away 4 months after she did and I cannot say I was sorry when they were gone. I miss them, but I celebrate that they had 69 years of love and marriage.
I lost them both in 2012.
Every time I have trouble remembering things, like scientific names, I wonder if it is the early stages.
I know exactly how you feel. We lost Mom in early 2012 after years of descent into dementia. Dad had been caregiver 24/7 for all that time, and he was lost after she passed. He died a couple months later. They used to hold hands and sing old songs.
I would volunteer to take the treatment in a second.
I am a cancer survivor, but I can say without any hesitation that I would rather die from cancer than dementia.
Indeed.

we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
to share.


Join the effort to solve medical problems, AIDS/HIV, Cancer and more with Team EvC! (click)

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Pressie
Member
Posts: 2103
From: Pretoria, SA
Joined: 06-18-2010


Message 11 of 13 (755192)
04-06-2015 8:25 AM


That would be such a relief to me. Both my parents have recently been diagnosed with the early stages of that dreadful disease.
It wasn't really a shock to me (all the signs are there and they are at different stages), but I really, really don't know how to cope with it.
I'm loosing both my parents. Physically, mentally and the finances involved to get them looked after. It's mind boggling.

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RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 12 of 13 (755193)
04-06-2015 9:18 AM
Reply to: Message 11 by Pressie
04-06-2015 8:25 AM


Sad to hear that. I think the worst part is that it is so slow but so unstoppable ...
Hope this technique is available in time to help. In the meantime sing or play music and dance, enjoy the time you have.
<3

we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
to share.


Join the effort to solve medical problems, AIDS/HIV, Cancer and more with Team EvC! (click)

This message is a reply to:
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ramoss
Member (Idle past 612 days)
Posts: 3228
Joined: 08-11-2004


Message 13 of 13 (755368)
04-07-2015 5:20 PM
Reply to: Message 11 by Pressie
04-06-2015 8:25 AM


While this certainly won't stop the progression of the disease, the use of music might make the time you have with them less painful. Supposedly, music activates different parts of the brain, and stimulates them, and might 'bring them back' for a short period of time.

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