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Author Topic:   Disadvantageous Mutations: Figures
Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 7 of 93 (794463)
11-16-2016 9:43 AM
Reply to: Message 1 by Gregory Rogers
11-16-2016 5:33 AM


I am not going to query the above arguments at this stage, as I suspect they’ve been done to death (although if anyone on either side wishes to add to the above set of points, feel free).
I agree with jar that you've got some of the argument wrong: DNA cannot "learn from its mistakes".
You have also omitted an important part of the argument: natural selection. Bad mutations will not persist long in the gene pool, because they are bad. Consequently, if a species did have a 10:1 ratio of bad mutations to good ones, this would not cause it problems, indeed it would improve over time. (Unless it had a small fixed population --- I mean really small, like low double figures. In that case a "genetic meltdown" would be possible.)
I would add that before you can judge any scientific theory as being right or wrong, you need to know exactly what it says. I have seen someone on the internet reject the law of conservation of energy --- because he didn't know the difference between energy and force! So when you're talking about the theory of evolution, and on the one hand you say that DNA "learns from its mistakes", and on the other hand you never mention natural selection, then you're getting it wrong, and until you know exactly what the theory says you shouldn't be convinced either way. Even if I convince you that it's right --- which I would like to --- you'd be a sucker to believe that it's right on my say-so if you don't really know what it is.
Simply, then, what is the percentage of fossils and skeletal remains unearthed so far where clear negative, that is, disadvantageous, mutations, are in evidence?
That's quite small. Nor would be expect it to be large. Look at our own species, and see how many disadvantageous mutations would be visible in the fossil record. Most clear disadvantageous mutations are diseases of metabolic function. (It is likely that in fact most disadvantageous mutations simply prevent gestation.)
Then consider those mutations that would show up in the fossil record, such as achondroplasic dwarfism. We would certainly notice it, but even in that case we would only know that it was the record of a disadvantageous mutation because we already know that that's what achondroplasic dwarfism is, if you see what I mean. So if we found a fossil trilobite (say) that had suffered a similar mutation, we wouldn't in fact say "here is a trilobite with a deleterious mutation", we'd say "here is a new species of trilobite".
And then if we did find something clearly wrong, it might not be clear whether it was a mutant. Here, for example, is a two-headed fossil.
Surely, you say, surely this is a clear example of a deleterious mutation. Nope, it's probably a developmental disorder. But without knowing whether the condition is heritable, how would we tell for sure?
I hope this helps.
Edited by Dr Adequate, : No reason given.
Edited by Dr Adequate, : No reason given.
Edited by Dr Adequate, : No reason given.
Edited by Dr Adequate, : No reason given.

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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 9 of 93 (794466)
11-16-2016 10:42 AM
Reply to: Message 6 by Stile
11-16-2016 8:57 AM


Re: Never settle
What makes you think resolving such an issue "once and for all" is a good thing?
A true seeker-of-knowledge never "settles" any issue. Things just have a higher or lesser degree of confidence.
Well, y'know, epistemological quibbles aside, I am fairly sure that the Earth is not flat; I am certain enough that I have basically stopped thinking about the question. In practice, we regard some questions as closed.
(You may reply that by participating in this forum I am in practice treating evolution as an open question, to which I would reply that yeah, that is kind of an odd hobby I have here. Which is why this is a fairly small forum.)
Edited by Dr Adequate, : No reason given.

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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 10 of 93 (794467)
11-16-2016 10:52 AM
Reply to: Message 1 by Gregory Rogers
11-16-2016 5:33 AM


Why Is This The Crucial Question?
This will be my second post re the Creation-Evolution controversy, in an attempt to resolve the issue in my mind once and for all. [...] Simply, then, what is the percentage of fossils and skeletal remains unearthed so far where clear negative, that is, disadvantageous, mutations, are in evidence?
But I am slightly puzzled, now I think about it. Why in the world would the answer to this question, of all questions, resolve the issue in your mind once and for all? Why is this the crucial question?
Its relevance is so obscure that I can't even see which way the answer would sway you. If I tell you that there are few clear examples of deleterious mutations preserved in the fossil record, would that make you (a) a convinced evolutionist (b) a die-hard creationist?
(I'm guessing (a), but I do vaguely recall Anne Coulter saying that the paucity of such fossils is an argument against evolution. But then she's a moron and you are not.)

This message is a reply to:
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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 16 of 93 (794578)
11-17-2016 12:13 PM
Reply to: Message 13 by Pressie
11-17-2016 7:42 AM


Pressie. You know how much I owe to you, and how deeply I respect you --- but shut up. Why should we mind if someone asks questions about a matter of fact? We have the answers. Sit down.
What if he did start asking questions about the creationist nonsense about "genetic information"? --- which he might, now you've tipped him off. The greatest single destruction ever of that line of argument was written on these forums, by me. I am ready and willing to answer any questions he may ask on that subject.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 13 by Pressie, posted 11-17-2016 7:42 AM Pressie has replied

Replies to this message:
 Message 17 by NoNukes, posted 11-17-2016 12:22 PM Dr Adequate has replied
 Message 22 by Pressie, posted 11-18-2016 6:59 AM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


(3)
Message 18 of 93 (794582)
11-17-2016 12:34 PM
Reply to: Message 17 by NoNukes
11-17-2016 12:22 PM


We should not mind. However it is noteworthy that this poster has made a total of five posts to these forums, with two of those posts being requests to start new threads. He does not seem to be very big on participating in the discussions he starts.
Well, he does follow up to a certain extent. But yeah, he doesn't follow up so much. Which is what makes me think that he's asking perfectly honest questions. When I answer his questions, in detail and at length, then a creationist would unleash a Gish Gallop and this thread would keep us all entertained for the next three months. But if he is, as he appears to be, a genuine seeker after facts, then he's got 'em, so he can leave it at that.
This worry about why he's asking questions does not show our side at all in a good light. The fact that we can answer them all does.
Edited by Dr Adequate, : No reason given.

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Replies to this message:
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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 21 of 93 (794607)
11-17-2016 9:49 PM
Reply to: Message 20 by AnswersInGenitals
11-17-2016 7:01 PM


Re: There are no disadvantageous mutations.
Nonetheless the title of your post is somewhat ... rhetorical, shall we say? As in not true?

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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


(3)
Message 23 of 93 (794614)
11-18-2016 10:34 AM
Reply to: Message 22 by Pressie
11-18-2016 6:59 AM


To me it's just unbelievable that someone would read a few creationist tracts and then think that it's 'scientific'.
That's not unbelievable at all. That's what the tracts are for! It would be strange if none of them ever fulfilled its exact function.
Try and imagine you don't really know anything about the "controversy". (This is a worthwhile effort. One of the hardest things for someone who wishes to teach a subject is to remember what it was like to know nothing about it.) Then you read a creationist tract. Here you find someone making confident statements about genetics, and the fossil record, and the Second Law of Thermodynamics, and so on. It is on the face of it hard to believe that a grown man sat down and wrote this stuff, with bland, confident assurance, and had it published to instruct the general public, and yet had never researched any of the topics sufficiently to even be using the vocabulary correctly. That is hard to believe! It is more plausible on the face of it to think that there must be arguments on both sides, or one side wouldn't be arguing.

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Replies to this message:
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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 33 of 93 (797480)
01-22-2017 4:10 AM
Reply to: Message 32 by CRR
01-22-2017 3:08 AM


However even the very few beneficial mutations are usually information losing in some way.
How are you quantifying information?
For evolution; microbes → man; to work requires addition of large amounts of genetic information. Of course devolution; man → microbes; will work with loss of genetic information.
An assertion which is literally meaningless unless you tell us how you're quantifying information.
Moving microbes to man requires thousands of new proteins. A major problem is that functional proteins appear to be exceedingly rare in the space of all proteins. Axe estimated it to be about 1/10^77. This makes de novo production of new proteins practically impossible. Even minor changes in existing are unlikely if more than a few non beneficial steps separate beneficial ones.
Evolutionists usually appeal to large numbers of organisms and deep time to overcome these probabilistic barriers but the Denton has estimated that only 10^40 proteins could have existed in all of earth's history and this is simply not enough to make the evolution story plausible.
You're not going to show your working?
Edited by Dr Adequate, : No reason given.

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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 45 of 93 (797798)
01-27-2017 11:12 AM
Reply to: Message 38 by CRR
01-27-2017 3:23 AM


You are suggesting that without these data information can't be said to be gained or lost.
Is there such a thing as beauty? Can one woman be more beautiful than another? But how is beauty defined, quantified, measured, and what are the units of measurement?
Are you trying to suggest that the amount of information in a genome is a mere subjective opinion like which of two women is prettier?
Then what use do you wish to make of the concept in a discussion of science? When you say that "mutations are usually information losing", how would that be different from me saying "Eyeshadow usually makes women less attractive"? If the information in a genome is not an objective fact about it, but a subjective feeling you have about it, then what relevance does it have for science? Suppose I were to reply that I personally feel that most mutations increase information, what then? Wouldn't we just have to say "ah well, tastes differ"?
So we don't have to precisely define, quantify, and measure information for it to be real and for us to talk comparatively about gain or loss of information. E Coli has a genome of ~5e6 base pairs and ~5000 genes. Humans have a genome of ~3e9 base pairs and ~20,000 genes. There is little doubt that the human genome contains more information than the E. coli genome.
So, would you like the size of the genome to be the measure of the amount of information in it? That would be fine by me, the standard creationist blather about information is false given any coherent definition of it.
Edited by Dr Adequate, : No reason given.

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Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 65 of 93 (801301)
03-04-2017 11:09 PM
Reply to: Message 64 by CRR
03-04-2017 9:56 PM


It's a lot more than "chemical doing chemistry".
Nope.
If that was all the frog in a blender experiment should work.
Your reference is obscure and your reasoning absent.
The extreme rarity of functional proteins means that it is practically impossible to get from one functioning protein to another by incremental beneficial steps.
Then it's strange how often it happens.
Let alone explaining the appearance of the original protein.
Some people have tried to explain this with reference to the activity of an invisible wizard who lives in the sky, but of course that just raises the question of what processes could produce an invisible sky-wizard.

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 Message 64 by CRR, posted 03-04-2017 9:56 PM CRR has replied

Replies to this message:
 Message 67 by CRR, posted 03-05-2017 4:56 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 69 of 93 (801403)
03-05-2017 9:38 PM
Reply to: Message 67 by CRR
03-05-2017 4:56 PM


Put a frog in a blender and blend well. All the chemicals are there so the chemical reactions should continue if it's just chemicals doing chemistry.
If you mash up any chemical system you'll change the outcome of the chemical process. 'Cos of, you know, breaking the test-tubes and stuff.
Smash it to pieces, it won't work any more than the frog does.
Then you should have no problem giving 5 observed examples.
http://www.gate.net/~rwms/EvoMutations.html

This message is a reply to:
 Message 67 by CRR, posted 03-05-2017 4:56 PM CRR has replied

Replies to this message:
 Message 79 by CRR, posted 03-15-2017 1:39 AM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 81 of 93 (802343)
03-15-2017 10:43 AM
Reply to: Message 79 by CRR
03-15-2017 1:39 AM


Precisely. Life is more than just chemical reactions.
Yeah, there's also pixie dust and unicorn farts ... wait, no there isn't, what's your point?
Which are your 5 examples?
If you didn't read it, I suggest you do so.

This message is a reply to:
 Message 79 by CRR, posted 03-15-2017 1:39 AM CRR has replied

Replies to this message:
 Message 82 by CRR, posted 03-20-2017 6:47 AM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 85 of 93 (802831)
03-20-2017 3:37 PM
Reply to: Message 82 by CRR
03-20-2017 6:47 AM


I think the peer-reviewed scientific papers may be more accurate than a failed propaganda organization. But if you think they have any good points backed up by actual evidence, please do present the evidence.

This message is a reply to:
 Message 82 by CRR, posted 03-20-2017 6:47 AM CRR has replied

Replies to this message:
 Message 86 by CRR, posted 03-20-2017 10:11 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 303 days)
Posts: 16113
Joined: 07-20-2006


Message 88 of 93 (802860)
03-20-2017 11:41 PM
Reply to: Message 86 by CRR
03-20-2017 10:11 PM


You've got some nerve criticising my use of the Discovery Institute when you referenced a web site that doesn't even show the author's affiliations or qualifications.
But we can assume he's not affiliated with the Discovery Institute, so he's got that going for him. Also copious references to the peer-reviewed scientific literature.
I note that you declined my invitation; let me repeat it: "if you think they have any good points backed up by actual evidence, please do present the evidence."
I have in fact heard of Ann Gauger. Here she is in a Discovery Institute video, standing in front of what appears to be a Real Scientific Laboratory Where Science People Do Science ...
... but which is in fact a stock photograph.
It is hard to think of a more perfect metaphor for "creation science".

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Replies to this message:
 Message 89 by NoNukes, posted 03-21-2017 3:28 PM Dr Adequate has not replied
 Message 90 by Pressie, posted 03-24-2017 6:16 AM Dr Adequate has not replied

  
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