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Author Topic:   Disadvantageous Mutations: Figures
New Cat's Eye
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Posts: 11096
From: near St. Louis
Joined: 01-27-2005
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Message 61 of 61 (798925)
02-06-2017 3:08 PM
Reply to: Message 47 by CRR
02-01-2017 6:47 AM


Errr, no. It is quite obvious that the probability of landing on an edge is infinitesimal in the total result space.

That's what I'm saying. When you wrote:

quote:
A major problem is that functional proteins appear to be exceedingly rare in the space of all proteins. Axe estimated it to be about 1/10^77.

The probability of getting most of the proteins in "the space of all proteins" is also infinitesimal, so you have the wrong statistical estimate there. There is not equal weight on those improbable proteins forming so you can't include them like that in the estimate of the functional proteins forming. If you did, it would be just like including all the places where a coin could land on its edge in the calculation of the odds of it landing on heads or tails.

Rather the analogy would be that finding a functional proteins would correspond to a flipped coin landing on its edge.

Then something has to be wrong, because functional proteins do form. The problem is that proteins don't form from random pieces randomly coming together and joining mechanically. There's chemistry involved and some reactions are catalyzed and some are practically impossible. To calculate the odds of one particular protein forming out of the space of all proteins is not the right calculation to determine the chances of a particular protein forming.

In fact, some proteins could form inevitably.


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