"In the laboratory mouse, loss-of-function mutations at Mc1r are recessive and result in light color, whereas gain-of-function alleles are dominant and result in dark color (16)."
I was talking about loss of function between the MC1R gene and the agouti-signaling protein.
They are talking gain/loss of function as it relates to coat colour..
Dominant/recessive does not determine gain/loss of functional information. A normal light switch can be turned on or off. A broken light switch can result in a light permanently on (dominant) or permanently off (recessive); but the switch is broken in either case. Similarly with the MC1R gene.
Edited by CRR, : Changed subtitle