In Tennessee, the 2 term Republican incumbent , who supported the Tennessee Medicaid expansion, was defeated when a conservative Democrat got the support of right wing Republicans. Out with TennesseeCare or whatever the (now dead)health care program was called.
The old Smokey Mountain Republican was defeated by an old Democrat.
Fred Thompson ran in 1994 as a pro choice, pro gun control Republican (and won a landslide), but by the time he ran for president in 2008, he was a born again right winger.
Bob Riley won in Alabama and attempted to raise taxes to fund education.
In 2014, a Republican ran against Jerry Brown in California, and might have been more liberal (he seemed to be on homeless issues). He got killed.
In 1988, Joe Liebermann won against a liberal Republican incumbent, when right wingers made it a major thing to rid themselves of Lowell Weiker
Lincoln Chafee, in 2000, beat a conservative Democrat for a Senate seat. But lost in 2006.
Weicker lost in 1988 but ran for governor as an indi.
Chafee ran for governor in 2010 and won.
Edited by LamarkNewAge, : No reason given.