quote:
Now that I didn't know. Can I see the math/reasoning?
You can see the math in this paper: Maruyama T and Kimura M (1974), "A note on the speed of gene frequency changes in reverse directions in a finite population." Evolution 28: 161—163 (although a special case had been worked out earlier). The basic intuition (to the extent that there is one) is that the only way a deleterious allele is going to fix is if it experiences a number of substantial "lucky" upward fluctuations; if that's going to happen, it's probably going to happen quickly, since otherwise selection will drive it to or near extinction. Of course, the probability that the deleterious allele will fix is much lower than for the beneficial allele, but the time to fixation conditional on fixation turns out to be the same, for a given selection coefficient.