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Author Topic:   MicroRNA as Evidence for Evolution
caffeine
Member (Idle past 1025 days)
Posts: 1800
From: Prague, Czech Republic
Joined: 10-22-2008


Message 6 of 7 (791774)
09-21-2016 12:56 PM
Reply to: Message 3 by Taq
09-20-2016 5:14 PM


Re: miRNA secondary structure
The first clue to understanding the bigger picture is the placement of the loop structure in the overall sequence. That loop structure is found in the middle of the molecule. Where do you see the most differences between homologous miRNA sequences in distantly related species? In the middle of the miRNA molecule. Where do you see the least number of differences? In the stem portion of the miRNA molecule.
Unless I'm misunderstanding something, this seems to be flatly contradicted by the picture in your previous post. It shows that the ends of the molecule are more prone to vary than the middle. The middle is identical in all primates and rodents, while the ends start to vary once we hit monkeys.
I think I am a bit lost somewhere, though, as the ASCII picture doesn't seem to match the listed sequences. Based on the stars, the macaque sequence varies from the apes only in its final base, but the sequence written above also shows two As where apes have Gs (in the 96th and 100th position, counting from the left). What am I missing here?

This message is a reply to:
 Message 3 by Taq, posted 09-20-2016 5:14 PM Taq has replied

Replies to this message:
 Message 7 by Taq, posted 09-23-2016 10:20 AM caffeine has seen this message but not replied

  
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