The latter is pretty hard to be "induced" by NS, it is totally accidental. The former, perhaps already happened to some degree with dog breeds. Would the hybrids of a great dane and a chihuahua by viable? I don't know, but I wouldn't be surprised if not.
IIRC, there's a couple of large dog breeds which you must never breed together, because one of them is large by virtue of producing more growth hormone, and the other by virtue of being more sensitive to growth hormone, producing a developmental disaster when you put the genes together.
I'm sorry I can't remember more, give references,
et cetera ... does anyone else know more about this?
Edited by Dr Adequate, : No reason given.