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Author Topic:   ZFX and ZFY
Convince-me
Inactive Member


Message 1 of 5 (36483)
04-08-2003 9:41 AM


I took the sequence-part of ZFX and ZFY that NCBI - National Center for Biotechnology Information - has of the spieces below and compared them with man and aligned them.
ZFY showed a good gradual change. The numbers are in percent similarity.
Man — 90,9 - Dog
Man — 91,4 - Ring-tailed lemur
Man — 96,7 — Siamang
Man — 96,7 — Agile gibbon
Man — 98,0 — Orangutan
Man — 99,2 — Gorilla
Man — 99,5 — Chimpanzee
ZFX showed a slower mutation rate than ZFY.
Man — 95,7 - Hund
Man — 96,7 - Katta
Man — 99,7 — Hylobates agilis
Man — 99,7 — Siamang
Man — 99,7 — Orangutang
Man — 99,7 — Gorilla
This might be very well known to all of you. Would this mean that ZFX produces a good working protein and are very sensitive for changes and that zink finger proteins from y-chromosomes of these spieces hardly work or doesnt work or are switched off, just because they have changed faster?
And what is the creation explanation for this.

Replies to this message:
 Message 2 by Convince-me, posted 04-08-2003 9:45 AM Convince-me has not replied

  
Convince-me
Inactive Member


Message 2 of 5 (36484)
04-08-2003 9:45 AM
Reply to: Message 1 by Convince-me
04-08-2003 9:41 AM


Some translations.
ZFX showed a slower mutation rate than ZFY.
Man — 95,7 - Dog
Man — 96,7 - Ring-tailed lemur
Man — 99,7 — Hylobates agilis
Man — 99,7 — Siamang
Man — 99,7 — Orangutan
Man — 99,7 — Gorilla

This message is a reply to:
 Message 1 by Convince-me, posted 04-08-2003 9:41 AM Convince-me has not replied

  
Adminnemooseus
Administrator
Posts: 3976
Joined: 09-26-2002


Message 3 of 5 (36499)
04-08-2003 2:45 PM


Topic diffusion happening???
This topic seems to be a continuation of the now closed "No mutations in neutral gene-parts?" at http://EvC Forum: No mutations in neutral gene-parts?
Currently, Convince-me has started 5 topics (see http://http://www.evcforum.net/cgi-bin/membermsglist.cgi?action=...), with seemingly a fair amount of overlap between them.
I fear that Convince-me is showing signs of becoming a bit of a version of a "Peter Borger" type poster (albeit with a clearer defined content).
Convince-me, I suggest that you take care in maintaining a focus, and not spread the same ideas over too many topics.
This message is NOT intended to be a disciplanary warning (ie. There is no suspension pending); Just an effort to head off what seems to be a potential problem.
I may be wrong.
Adminnemooseus
ps: Convince-me, I actually do like your messages, but please consider the above suggestions.
------------------
{mnmoose@lakenet.com}

Replies to this message:
 Message 4 by Convince-me, posted 04-09-2003 12:34 PM Adminnemooseus has not replied

  
Convince-me
Inactive Member


Message 4 of 5 (36583)
04-09-2003 12:34 PM
Reply to: Message 3 by Adminnemooseus
04-08-2003 2:45 PM


Re: Topic diffusion happening???
Ok, I will keep to this topic. The reason I started a new topic was to get attention for my question. If no one answers that question I will get information about this on other sites.

This message is a reply to:
 Message 3 by Adminnemooseus, posted 04-08-2003 2:45 PM Adminnemooseus has not replied

  
Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 5 of 5 (36674)
04-10-2003 11:24 AM


As far as I can see from the literature, the main reason is theorised to be that the Y linked gene mutates more rapidly because more mutations are produced in males given the continuous production of sperm. I havent seen anything to suggest that the ZFY protein is substantially less effective.
For references see
Lori-Jayne Lawson , Godfrey M. Hewitt
Comparison of Substitution Rates in ZFX and ZFY Introns of Sheep and Goat Related Species Supports the Hypothesis of Male-Biased Mutation Rates
J Mol Evol 2002 Jan;54(1):54-61
Erlandsson R, Wilson JF, Paabo S.
Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans.
Mol Biol Evol. 2000 May;17(5):804-12.
Shimmin LC, Chang BH, Li WH.
Male-driven evolution of DNA sequences.
Nature. 1993 Apr 22;362(6422):745-7.
[This message has been edited by Wounded King, 04-10-2003]

  
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