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Author Topic:   Homochirality question
Coragyps
Member (Idle past 761 days)
Posts: 5553
From: Snyder, Texas, USA
Joined: 11-12-2002


Message 4 of 7 (199801)
04-16-2005 7:45 PM
Reply to: Message 1 by SiniSha
04-16-2005 9:01 AM


My thoughts on why we're all made of L-amino acids and D-sugars is that it was "luck" - the very early almost-life forms with L-amino acids got a small head start and "ate" the D-forms. Polypeptides (chains of amino acids) with both chiralities would be much more disordered - by which I mean only that they would have a much tougher time forming the neat little coils and pleats we see in homochiral proteins - and would probably lose out in any self-catalytic games that would lead to more of themselves.
If I muster the energy, I'll try to go look up how sugars and amino acids are biosynthesized wrt their handedness. I'll bet a nickel that sugars are D because amino acids are L, or perhaps vice versa.
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This message has been edited by Coragyps, 04-16-2005 06:46 PM

This message is a reply to:
 Message 1 by SiniSha, posted 04-16-2005 9:01 AM SiniSha has replied

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 Message 5 by SiniSha, posted 04-17-2005 1:41 PM Coragyps has replied

  
Coragyps
Member (Idle past 761 days)
Posts: 5553
From: Snyder, Texas, USA
Joined: 11-12-2002


Message 6 of 7 (199913)
04-17-2005 2:24 PM
Reply to: Message 5 by SiniSha
04-17-2005 1:41 PM


I understood it but didn't answer too clearly.
I'm guessing here, but perhaps early life or proto-life was non-specific enough in its reactions that it was able to assimilate D-amino acids or L-sugars for their carbon and nitrogen - catabolizing them for raw materials instead of racemizing or using them directly. I don't know what modern life forms do with wrong-handed nutrients, asides from an old science fiction story where a guy got "wormholed" into his mirror-image and slowly starved.....
And the more I think on it, the more sure I am that D-sugars are a direct consequence of L-aa's getting an upper hand early on. My biochem was too far in the past and too sketchy to say just how.

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