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Author Topic:   Macroevolution: Its all around us...
randman 
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Posts: 6367
Joined: 05-26-2005


Message 248 of 306 (219001)
06-23-2005 1:25 PM
Reply to: Message 246 by TimChase
06-23-2005 12:57 PM


Re: Relevance?
Quite true -- particularly if you are willing to apply the term "theory" to a highly conjectural game of smoke and mirrors...
You mean ToE?

This message is a reply to:
 Message 246 by TimChase, posted 06-23-2005 12:57 PM TimChase has replied

Replies to this message:
 Message 252 by TimChase, posted 06-23-2005 1:55 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 250 of 306 (219007)
06-23-2005 1:41 PM
Reply to: Message 249 by pink sasquatch
06-23-2005 1:28 PM


Re: understanding?
I don't want to be overly reactionary, and sometimes other posters responses affect my tone towards those not being uncivil. Sorry.
There is no evidence for convergent evolution of coding or pseudo-coding sequence.
I assumed with the above-comment that you were denying convergent DNA was real.
Is it really "an area of intense study"? How many labs are working on the problem? How many papers have been published on the subject?
I don't know how many labs are working on it. WK here made the comment that it was a "hot topic" and a cursury review seemed to verify that.
Do you think that is incorrect?
You can't simply take evidence from one class of DNA sequence and immediately extend it DNA in general - that is where I believe the root of your "overreaching" lies.
I guess I disagree here. One of the bedrock principles of common descent is that all DNA is essentially the same thing, but with different compositions, etc,..but exhibiting such similarity that it is used as an argument for universal common descent. I don't really deny that it can be used for evidence of common descent.
Along with that, if we discover that DNA has convergent properties within it, then to me it is reasonable to think that holds true across the board. So if human DNA exhibits a predisposition to mutate according to a certain pattern, it is likely that all DNA has within it, an embedded predisposition to mutate according to certain patters.
Imp, it is too early to know the extent of this phenomena, and the mechanisms involved, but considering the fundamental role DNA plays in reproduction and any presumed evolutionary processes, the fact DNA displays any convergency at all and is not just random is quite revealing, and it's effects should not be discounted until further understood.
One way to look at the patterns certain DNA is predisposed towards is to see those patterns as an embedded design.
This message has been edited by randman, 06-23-2005 01:48 PM

This message is a reply to:
 Message 249 by pink sasquatch, posted 06-23-2005 1:28 PM pink sasquatch has replied

Replies to this message:
 Message 254 by pink sasquatch, posted 06-23-2005 2:13 PM randman has replied

randman 
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Posts: 6367
Joined: 05-26-2005


Message 253 of 306 (219019)
06-23-2005 2:10 PM
Reply to: Message 252 by TimChase
06-23-2005 1:55 PM


Re: Relevance?
Wrong. It is fallacious to compare the reality of convergent DNA with endogenous retroviruses, as you have done.
The simple fact is that if DNA contains within it, a certain predisposition to mutate towards a certain pattern, depending upon the existing pattern, and not to just mutate randomly, then that is an embedded characteristic of DNA. So there is a cause creating an effect.
You seem to be arguing that the effect is via chance, and thus make a fallacious argument.
because when two species have endogenous retroviruses in exactly the same position, they could have very well been infected separately, and by some incredible coincidence, the point of insertion may have been the very same in both cases.
There is no appeal to chance or coincidence in any of my posts here at all. You are misrepresenting the argument. Maybe you don't understand it?
I'll just repeat it and maybe you will get it this time.
There is embedded within certain patterns of DNA a predisposition to mutate according to a pattern and not just randomly.
Right now, we do not know the extent of this phenomena, but may know more in a few years.
But it is a reasonable assumption that if we see this characteristic in human DNA that it is likely true across the board for all species.
Why is that so hard for you to grasp?
As far as a statement, I provided a link to an entire scientific paper. I suggest you read it. WK originally provided the link, and it could be useful if you would take the time to learn a little about the subject, especially since you seem to be qualified to understand the terms and concepts.

This message is a reply to:
 Message 252 by TimChase, posted 06-23-2005 1:55 PM TimChase has replied

Replies to this message:
 Message 255 by TimChase, posted 06-23-2005 2:26 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 256 of 306 (219030)
06-23-2005 2:35 PM
Reply to: Message 254 by pink sasquatch
06-23-2005 2:13 PM


Re: does pattern = design?
On the first part of your post, my understanding is that is not the only study, and that the evidence does indicate a larger convergent effect for DNA.
WK probably could provide better details, but at the same time, I think there is a considerable level of research going on, and we don't have a full picture yet.
That would be the case if any pattern was indicative of design, which I do not feel is the case. Just because certain DNA sequences form a pattern because they are mutable or stabilized at a molecular/biochemical level does not indicate design to me, especially since those sequence have no apparent function outside of themselves.
The pattern itself is a design. It doesn't just indicate a design. I should be more careful. It is a design that preexists based on whatever is causing it, which is presumed at this stage to the chemical properties in the local environment.
In other words, I see chemistry as the result of the pattern where you see design - when minerals stabilize themselves into patterned crystals, I see chemistry at work, not design. What about you?
Chemistry may be the result of the pattern, but the pattern is a design that already exists then, which is based on the properties of chemistry. Either way, we are beginning to have to go beyond biology to understand what occurs. The biology is dependant on the DNA which is influenced and dependant on chemistry which is affected by physics, including quantum physics.
Imo, if we are going to get a good grasp of what is really going on, we need a comprehensive understanding of quantum physics, chemistry, and molecular genetics.
I suspect once we view the entirety of the process, we will see a mechanism for direct design influencing "natural processes".
This message has been edited by randman, 06-23-2005 02:37 PM

This message is a reply to:
 Message 254 by pink sasquatch, posted 06-23-2005 2:13 PM pink sasquatch has replied

Replies to this message:
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randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 257 of 306 (219033)
06-23-2005 2:39 PM
Reply to: Message 255 by TimChase
06-23-2005 2:26 PM


Re: Relevance?
So you are willing to admit that retroviruses are a kind of smoking gun for evolution?
No, not at all.

This message is a reply to:
 Message 255 by TimChase, posted 06-23-2005 2:26 PM TimChase has not replied

randman 
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Posts: 6367
Joined: 05-26-2005


Message 269 of 306 (219098)
06-23-2005 6:11 PM
Reply to: Message 261 by pink sasquatch
06-23-2005 4:18 PM


Re: strength---
I'm now wondering about the strength of this form of "convergent evolution" - in my mind I think of it as a rather "weak" force that would not be able to overcome the "strong" selective force of maintaining a phenotypically beneficial gene or sequence.
You have no evidence offered to back up such a view. Furthermore, your idea assumes that the pattern would run contrary to the "selective force" when the opposite could well be the case.
it seems to me that the convergent pattern they suggest would be unlikely to converge to functional gene sequence; that is, the pattern they uncover is unlike the vast majority of gene sequences. Do you think that is a fair conclusion?
No, it does not seem like a fair conclusion. Can you elaborate?
I think there should also be a recognition in considering this that some "solutions" may be equally positive for selection, but in that case, the pattern that first and most frequently emerges is more likely to emerge dominant.

This message is a reply to:
 Message 261 by pink sasquatch, posted 06-23-2005 4:18 PM pink sasquatch has replied

Replies to this message:
 Message 272 by pink sasquatch, posted 06-23-2005 6:52 PM randman has replied
 Message 273 by EZscience, posted 06-23-2005 6:57 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 270 of 306 (219099)
06-23-2005 6:13 PM
Reply to: Message 262 by crashfrog
06-23-2005 4:23 PM


that is illogical
How do the specific "seed" sequences get from one species to another?
Your post, imo, seems nonsensical. Why is there any necessity of "seed" sequences to get from one species to another.

This message is a reply to:
 Message 262 by crashfrog, posted 06-23-2005 4:23 PM crashfrog has replied

Replies to this message:
 Message 278 by crashfrog, posted 06-23-2005 8:07 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 271 of 306 (219101)
06-23-2005 6:15 PM
Reply to: Message 264 by pink sasquatch
06-23-2005 4:41 PM


Re: ACAC
since it doesn't appear that the convergent mutational bias is a particular issue for other types of sequence
What evidence do you have of that? Can you show extensive studies that show other sequences are unlikely or do not show convergent tendencies?

This message is a reply to:
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randman 
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Posts: 6367
Joined: 05-26-2005


Message 274 of 306 (219117)
06-23-2005 7:07 PM
Reply to: Message 272 by pink sasquatch
06-23-2005 6:52 PM


Re: strength---
If they were equally positive they would be additive or cancel each other out. One would not be dominant.
No, you miss the point. There could be potentially equal solutions, but the one that gets their first is probably going to win.
That's why I pointed this out. A "weaker" force can still dominant a "stronger" force by virtue of appearing first. The stronger force you posit of natural selection would nonetheless only be able to act upon whatever mutations were offerred to it, and so in reality, the convergent aspects of DNA, to the degree that is real, would exert dominance over the selective process via occuring prior and acting as a sort of control.
Now, the only way the convergent pattern could arise and maintain itself would be if selection either encouraged it, or did not stop it at least.
That's my point, which despite your bashing, is fairly reasonable to me.
Do you see it any differently?

This message is a reply to:
 Message 272 by pink sasquatch, posted 06-23-2005 6:52 PM pink sasquatch has replied

Replies to this message:
 Message 277 by pink sasquatch, posted 06-23-2005 8:01 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 275 of 306 (219118)
06-23-2005 7:12 PM
Reply to: Message 273 by EZscience
06-23-2005 6:57 PM


Re: strength---
EZ, as usual for you it seems, you bash something I said erroneously.
I was simply responding to:
I'm now wondering about the strength of this form of "convergent evolution" - in my mind I think of it as a rather "weak" force that would not be able to overcome the "strong" selective force of maintaining a phenotypically beneficial gene or sequence.
The use of "beneficial" indicates to me "natural selection", and hence my comment on that.
So "we" meaning you and me or the rest of the board were not in fact only discussing non-coding DNA, and considering I was the one that brought this up, maybe you should be more careful in stating what "we" are discussing, or better yet, avoid the discussion if you don't want anyone disagreeing with you.
Moreover, what you also don't realize, nor will admit to, is that the likelihood exists that if DNA in general is convergent in non-coding sequences, it is probably convergent elsewhere.
That's the whole point.
You seem to argue that this is unlikely. On what basis do you assert that?

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 Message 273 by EZscience, posted 06-23-2005 6:57 PM EZscience has not replied

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 Message 276 by pink sasquatch, posted 06-23-2005 7:53 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 279 of 306 (219160)
06-23-2005 10:27 PM
Reply to: Message 276 by pink sasquatch
06-23-2005 7:53 PM


Re: leaping again : NINJA!
What's to stop it? Actually, that's an unfair question, but just want to throw the typical evolutionist refrain back out there.
You are though, imo, maintaining that DNA is not convergent or even highly convergent without evidence for that.
The paper states that one proposed cause for DNA convergency is the local environment. I see no reason if the local environment has an effect in the area they studied that it would not have a similar effect elsewhere.
I have never denied that this is a new area of research, but then again, the contention that DNA is not convergent is unproven. Basing models on an unproven assumption which looks to be increasingly an erroneous conclusion is fallacious, and yet that's what evolutionists have done.
That seems par for the course though for evolutionists. Assert that something is essentially a fact based on unproven assumptions.
As far as evidence for DNA convergency, we don't know which similarities arose convergently and which via common ancestry.
This message has been edited by randman, 06-23-2005 10:33 PM

This message is a reply to:
 Message 276 by pink sasquatch, posted 06-23-2005 7:53 PM pink sasquatch has replied

Replies to this message:
 Message 281 by pink sasquatch, posted 06-23-2005 10:50 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 280 of 306 (219166)
06-23-2005 10:43 PM
Reply to: Message 277 by pink sasquatch
06-23-2005 8:01 PM


Re: strength---
Two guys arm wrestle. One guy pushes first, but is much, much weaker, and the other guy beats him easily.
Your "first come, first served" idea doesn't make any sense.
That's a very poor analogy. Once again, you are juxtaposing forces as adversarial when that's not the case.
As far as equal solutions that could arise randomly or via convergent predispositions, the one that gets there first is the only one on the scene. A better analogy would be who's going to win a race today, me, a somewhat out-of-shape dude nearing 40 or the fastest man in the world but he hasn't been born yet. Sorry, but I'm still going to win every time.
Whoever gets their first is going to win by virtue of being the only contestant on the scene.
Same with presumed beneficial mutations. If there is a predisposition, it's going to come up more frequently and has a higher chance of success than something that may never come up at all.
On the idea of natural selection and mutations, it may be difficult for you to grasp but it's pretty simple. Natural selection alone does not produce mutations. It must act upon what is there. It doesn't choose what to select for. It acts as a filter for what has already been chosen.
In this case, if there is a predisposition towards a genetic pattern, if that pattern is congruent with natural selection, the pattern is not at odds with natural selection, and thus natural selection is not going to favor even more favorable designs because they don't come up.
Right - you're actually restating my conjecture that you said was incorrect a few replies back.
No, I am not repeating your conjecture. You presented the 2 forces as adversarial, and that's not accurate. One precedes the other, and may or may not be adversarial.

This message is a reply to:
 Message 277 by pink sasquatch, posted 06-23-2005 8:01 PM pink sasquatch has replied

Replies to this message:
 Message 284 by pink sasquatch, posted 06-23-2005 11:07 PM randman has replied

randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 282 of 306 (219173)
06-23-2005 10:54 PM
Reply to: Message 278 by crashfrog
06-23-2005 8:07 PM


Re: that is illogical
The paper shows that the "convergence" occurs ajacent to a specific sequence.
So what do you make of that? Why is that? Unless and until you can fully answer that, you have a very incomplete understanding of how genetic sequences emerge, and thus a very poor understanding of how genetic evidence may or may not be evidence for common ancestry.
I posit it is reasonable to assume that all sequences have predispositions towards a certain pattern. The evidence one sequence has this characteristic is indicative that this is probably part of the general characteristics of DNA, and the authors make that point by stating that DNA mutation is not random based on their study.
If you propose that the convergence effect explains genetic similarities between species, then the seed sequence has to already be in the genome of each species whose genetics "converged." (Otherwise, no genetic convergence would have taken place.)
Actually, no, not at all. The seed sequence can arise independently, and if the study's implications are correct, and certain sequences are predisposed to mutate along a certain pattern, then it is likely that there could be genetic sequences emerge that arose completely independently of one another.
So now you have to explain why multiple, independant, unrelated species each carry this genetic seed
Actually, evolutionists already claim that species can evolve to just about any sequence. I am not as convinced of that, but for you to argue that evolution can occur, and then argue that it cannot, is unreasonable.
You have to keep in mind if parts of DNA are predisposed to mutate according to a certain pattern, and new patterns once they emerge all have a predisposition, then claiming that it is unlikely for there to be high degrees of convergent evolution of DNA due to it being statistically unlikely is faulty logic.
You are assuming mutations only occur by chance, but in fact they may well occur according to a pattern, an embedded design, perhaps governed by the chemical properties of the local environment.

This message is a reply to:
 Message 278 by crashfrog, posted 06-23-2005 8:07 PM crashfrog has replied

Replies to this message:
 Message 283 by crashfrog, posted 06-23-2005 11:04 PM randman has replied
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randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 286 of 306 (219212)
06-24-2005 1:42 AM
Reply to: Message 283 by crashfrog
06-23-2005 11:04 PM


If all sequences have such a predisposition, then why are sequences so different across the board?
Simple. Different sequences have different predispositions.
And what are the odds of that occuring across thousands of unrelated species?
Why the thousands of unrelated species argument? That's totally bogus since no one brought up thousands of unrelated species.
But to happen with regularity, I'd say pretty good odds since if certain sequences or aspects of combinations of DNA tend to start it off in a similar direction, that is a common causal effect that can produce a repitition in pattern.
So you haven't answered my question. How do those first sequences arise? Do you really expect us to believe that it happened, across many thousands of species, entirely by coincidence in such a way as to match phylogenies derived from independant stratiography?
No, I expect you to look at the evidence instead of creating a myth you insist is true and argue by asking others to present another myth and argue it is true.
Personally, I prefer to look at the evidence. I don't see mutations as random, and it appears DNA is convergent. How those facts fit into current models would be interesting if you guys were not so busy trying to deny reality.
By the way, phylogenies from morphologists often do not agree with phylogenies from molecular systemists. You are just, once again, relying on overstatement to bolster a weak case. Why not just admit that there is some disagreement?
Also, who said anything about coincidence? I posit causal mechanisms. You posit coincidence.
Lemme ask you something. Why should we accept the coincidence that animals flapping their appendages to eat flies would one day mutate fully adaptive wings?
What are the odds for that coincidence?
You can argue that some evidence backs Darwinism until you are blue in the face, but relying on overstatements does not help you. You argue that repitition of pseudogenetic sequences appearing in different species is an indication of genetic relatedness because there is no other reason for such similarities to be present in different species, say a chimp and human, unless they shared a common ancestor.
Convergent DNA disproves that. Convergent DNA shows there is another reason why pseudogenetic sequences can arise independently in different species, and though you and others here dogmatically assert otherwise without any evidence, the fact that convergent DNA is a reality is a good indication it occurs for coding DNA as well.
I predict we will see, as more research is done, that convergent DNA occurs across the board.
Of course, this may not result in evolutionists being less dogmatic, nor falsifying Darwinism because Darwinism is an unfalsifiable myth based on a simple observation, but greatly overstated and exagerrated.
Mutations need not be driven by chance for Darwinism to be true. They need simply be undetermined by environment.
But there are partly determined in all likelihood by the local environment.

This message is a reply to:
 Message 283 by crashfrog, posted 06-23-2005 11:04 PM crashfrog has replied

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randman 
Suspended Member (Idle past 4920 days)
Posts: 6367
Joined: 05-26-2005


Message 287 of 306 (219215)
06-24-2005 1:51 AM
Reply to: Message 283 by crashfrog
06-23-2005 11:04 PM


microsatellites do occur in coding DNA
We've already established that there's no selection pressure for these seed sequences, or for any pseudogenetic sequence of the type used for molecular phylogenics.
One thing I should point out to you is that microsatellites do occur in coding DNA as well. The study suggests that microsatellites somehow react with the local environment to create a non-random tendency in the DNA.
To dismiss any, or "establish", that there is no selection pressure because coding DNA displays no convergency is a totally unfounded statement on your part.
The only evidence I know of indicates convergency probably exists across the board.
Do you guys have any evidence suggesting there are no convergent tendencies in coding DNA?

This message is a reply to:
 Message 283 by crashfrog, posted 06-23-2005 11:04 PM crashfrog has replied

Replies to this message:
 Message 292 by crashfrog, posted 06-24-2005 7:40 AM randman has replied

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