I would like to explore with them, the limits of empiricism, and how our perceptual capabilities may limit what we can know/understand.
I think nwr expressed it well by stating that we will be able to address anything that effects our lives in some way. Things will either be visible directly to us, or indirectly by affecting something else in a way we can pick up with our senses. And if a thing can do neither, then it really doesn't matter that much.
However, the underlying truth is that while we can model things we sense directly or indirectly, we may not actually know the true nature of all things. The further an external "thing" gets from our direct senses, the more probable it is that we could mistake what that thing actually is and how it functions.
On top of that there may be things that don't matter much to us, but certainly do exist. If you have a problem is with lack of omniscience, then our sensory limits pose serious problems.
Are there some things we will never be able to understand due to the limits of our perceptions? If our 5 senses are all the input we get, does that mean there is some sort of data we may be being excluded from?
Yes, we have no ability to (at least at this point) understand or "know" that other people actually exist in the sense that our own "selves" exist. We cannot sense this sentience or the nature of it.
And we may actually be stranded from ourselves as well. While you may know you exist, the nature of the real you may always remain hidden as the system may be unable to sense all of its parts.
holmes
"...what a fool believes he sees, no wise man has the power to reason away.."(D. Bros)