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Author Topic:   What I have noticed about these debates...
Tranquility Base
Inactive Member


Message 14 of 238 (25172)
12-01-2002 7:28 PM
Reply to: Message 7 by Quetzal
12-01-2002 7:57 AM


Quetzal
The point is that it is up to the reader to distinguish between the idiot YECs, the misinformed YECs and the well informed and honest YECs. We can't control what uneducated YECs will post on websites!
YECS have to put up with uneducated and completely biased evolutionists just as much as you guys have to put up with misinformed, uneducated and biased YECs.
[This message has been edited by Tranquility Base, 12-01-2002]

This message is a reply to:
 Message 7 by Quetzal, posted 12-01-2002 7:57 AM Quetzal has replied

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Tranquility Base
Inactive Member


Message 73 of 238 (25689)
12-06-2002 4:14 AM
Reply to: Message 64 by Percy
12-05-2002 1:24 PM


Percy
One thing that that hasn't been taken into account is asking people who are about to get a science degree. Could it be that people doing that already think naturalistically more then the average? Of course.
I still admitt that more education tends to increase eovluitonary thinking but but not to the extent that you think (due to my first sentence) and not for the reason you suspect. It is becasue most universities teach evoluttion only and ridicule creation of course!

This message is a reply to:
 Message 64 by Percy, posted 12-05-2002 1:24 PM Percy has replied

Replies to this message:
 Message 74 by Mammuthus, posted 12-06-2002 4:24 AM Tranquility Base has replied
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Tranquility Base
Inactive Member


Message 75 of 238 (25691)
12-06-2002 4:27 AM
Reply to: Message 74 by Mammuthus
12-06-2002 4:24 AM


Direct ridiculing is pretty rare in universities I agree but I've seen it and definitely in research seminars.

This message is a reply to:
 Message 74 by Mammuthus, posted 12-06-2002 4:24 AM Mammuthus has replied

Replies to this message:
 Message 76 by Mammuthus, posted 12-06-2002 7:09 AM Tranquility Base has replied
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Tranquility Base
Inactive Member


Message 87 of 238 (25855)
12-07-2002 6:03 PM
Reply to: Message 76 by Mammuthus
12-06-2002 7:09 AM


Mammuthus
In a research seminar in Australia we recently (this year) had 'Of course some people don't believe in evoltuion but here is the sequence alignment' (as if that proved anything) with associated giggles from the audience. I'm not claiming any worse than that.
Of course at the departmental coffee table admision of creationism is about equal to admitting belief in a flat earth. Evolution has been accepted mainstream as fact. Anything else is treated as pseudo-science and thus, understandably, ridicule. I hate seudo-science myself of course. Some creatinists are scientifically complete crackpots (I wont comment on their spiritual state). You can judge me yourselves.

This message is a reply to:
 Message 76 by Mammuthus, posted 12-06-2002 7:09 AM Mammuthus has replied

Replies to this message:
 Message 88 by Mammuthus, posted 12-09-2002 3:33 AM Tranquility Base has replied
 Message 91 by nator, posted 12-09-2002 7:38 PM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 92 of 238 (26120)
12-09-2002 9:30 PM
Reply to: Message 88 by Mammuthus
12-09-2002 3:33 AM


Mammuthus
M writes:
What do you see is different about the acceptance by the scientific community of evolution and say the theory of gravity or any other mainstream science?
I do see these as different. Gravity can be tested across huge ranges of scale. Evolution can not. You cannot prove how any actual organ arrived, or any subsystem for that matter. All of the lab and field experiments on evolution show are allelic and gene loss effects. After milions of generations of flies and bacteria noeone has shown new subsystems arriving. We agree with all of the evolution you can show. All yo are left with is anatomies and genomes which you think evovled from each other. We only disagree on the part you haven't yet proved. Are we just stubborn or are we right? I believe the latter.
To be fair, this entire site should be labelled Abiogenesis vs Creationism.
I am not arguing simply against abiogenesis. I am arguing about all the gene families that arose since the first prokaryote. The gene families that arose to make the first eukaryote . . . vertebrate . . . mammal . . . primate. It's not all abiogenesis. Any evolution that requires non-allelic or non-gene loss modifications I will disagrewe with you on becasue there is no evidence for that.
Where you have come into conflict on this board (including with me) is when you as a structural biologist start proposing impossible scenarios i.e. "kinds" hyperspeciating after the great flood to fit the world into your religion.
I thouroughly agree that is partially creationist expectation but there are hints of it that I think are better than your hints of non-allelic macroevolution.
[This message has been edited by Tranquility Base, 12-09-2002]

This message is a reply to:
 Message 88 by Mammuthus, posted 12-09-2002 3:33 AM Mammuthus has replied

Replies to this message:
 Message 94 by Mammuthus, posted 12-10-2002 3:47 AM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 93 of 238 (26122)
12-09-2002 9:41 PM
Reply to: Message 91 by nator
12-09-2002 7:38 PM


Schraf
I don't consider any of the AIG, ICR or CRS creationists as crackpots. In the past I have had some disagreements with them on issues but there are very few areas I disagree with them on currently.
Those I would label scientific crackpots are the creation groupies that uncritically accept everything they read forever and think that evolutionists are idiots. Some of them have been mislead, others should know better. Most of them do it for the right reason (their faith) but some are seeking to 'prove' creation becasue of a lack of faith I suspect.
Don't you think that the fact that any "crackpot scientist" is given a voice, and even applauded, by the Creation "science" movement as long as he seems to be consistent with the Bible is the reason for the ridicule from mainstream scientific bodies?
I really can't think of anyone I would put in that category. No one is perfect but I could not put anyone from AIG,ICR or CRS in that category. On the contrary, I am very impressed with these career creationists.
[This message has been edited by Tranquility Base, 12-09-2002]

This message is a reply to:
 Message 91 by nator, posted 12-09-2002 7:38 PM nator has replied

Replies to this message:
 Message 95 by nator, posted 12-10-2002 9:06 AM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 97 of 238 (26236)
12-10-2002 5:42 PM
Reply to: Message 95 by nator
12-10-2002 9:06 AM


Schraf
I'll admitt that that evidence is suggestive that Gish ignored facts. I'd like to hear his side of it. Has he commented on this accusation? Have you looked for it?
Many of your so called 'got yas' turn out to be very hollow. You accuse us of misusing extracts from Riley, Ethridge, Patterson and Gould. I have tracked down the original material in many of these instances in our library and I still agree with the creationist use of this material in almost every case.
[This message has been edited by Tranquility Base, 12-10-2002]

This message is a reply to:
 Message 95 by nator, posted 12-10-2002 9:06 AM nator has replied

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Tranquility Base
Inactive Member


Message 98 of 238 (26237)
12-10-2002 5:58 PM
Reply to: Message 94 by Mammuthus
12-10-2002 3:47 AM


Mammuthus
TB:
I do see these as different. Gravity can be tested across huge ranges of scale. Evolution can not.
M: That statement is patently false TB.
Demonstrate a non-allelic example of macroevolution.
If you think that evoltuion has reached the same state as the X-ray structure of hemoglobin you are seriously deluded Mammuthus. In any normal sense of the word the structure of hemoglobin is undoubtedly a fact. The status of macroevolution is not comparable since all the data is compatible with creation + diversification via allelic evolution.
TB:
All of the lab and field experiments on evolution show are allelic and gene loss effects.
M: That is funny, I have even posted references that demonstrate gain of function mutations and duplications followed by mutation (as has SLPx)..perhaps you forgot?
Duplication and mutaiton is allelic. Te results are differnetiated by an allelic difference. The proteins have the same fold and biochemical function. Show me the origin of a novel gene family and a novel subsystem.
TB:
After milions of generations of flies and bacteria noeone has shown new subsystems arriving.
M: Except for the entire Hox gene cascade, or hemoglobin in bacteria etc etc?
But this is simply reuse of existing gene families. God could have done the reuse. Why is it automatically natural for you? That is only your assumption. When you mutate a hox gene and get extra body segments or legs don't you realise that not a sinlge new gene family has been evolved?
M: Then you cannot accept the theory of gravity TB. Or can you show how it works in all detail?
Regardless of how gravity works it is an epirical fact except in the most convoluted sense fo the word. You have not proven evolution. You have simply shown that life is made from reused pieces and at each level of complexity, brand new pieces. In additon you have shown that a given genome can be fine-tuned fro an envornment. We love this stuff as much as you do but it doesn't prove macroevolution.
M: I have posted evidence on many occassions. In our "kinds" debate I found references for every single case you mentioned was unknown. In every case it turned out someone was researching it and had evidence for evolution of the system.
I think your seriously overating your rebuttals Mammuthus. All you ever found was that some of the components in a new sytem are reused. that is equally compatible with God or evolution.
TB:
I thouroughly agree that is partially creationist expectation but there are hints of it that I think are better than your hints of non-allelic macroevolution.
M: However, you never provide said evidence except to say you merely believe it is so. My whole point is that I doubt you do this when exploring a structural biology question. If you were looking at the PrPc to PrPsc transition, I doubt you would just say you believe that it folds in such and such a way...you would start with the observation that the protein conformation is different between the two, develope a hypothesis, test it, and continue to experiment based on your results, continuing to refine and develope your hypothesis. Not just saying "oh well, some mythical being I believe in makes me believe it is due to some unobserved hypermutation event so I don't need to bother doing the science." I just don't get that you do this with evolutionary biology given your background.
We are talking about the origin of life. God is one possibility. I'm sorry you can't see the difference between the historical origin of life and the origin of a conformational change.
[This message has been edited by Tranquility Base, 12-10-2002]

This message is a reply to:
 Message 94 by Mammuthus, posted 12-10-2002 3:47 AM Mammuthus has replied

Replies to this message:
 Message 99 by Mammuthus, posted 12-12-2002 5:10 AM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 100 of 238 (26389)
12-12-2002 5:48 AM
Reply to: Message 99 by Mammuthus
12-12-2002 5:10 AM


Mammuthus
TB:
Demonstrate a non-allelic example of macroevolution.
M: You will have to be more specific...syncytin is one example, the RAG2 gene evolution is another. I will deal with your Hox gene fallacy below.
Care to give a one line sumamry of these examples?
M: Please "prove" the structure of hemoglobin. And for each step, please demonstrate how the X-ray analysis in any less indirect in its measurements than what a population geneticist does or a genomics researcher does.
Regardless of what crystal form is found, the eelctron density yields the same backbone fold for hemoglobin and it is differnt to that found for any other protein. NMR, a completely independent method finds eactly the same 3D structre from non-crystalized samples in solution.
What pop-genetisists do is very good science. But it is all allelic as you know. A genomics researcher does very good work too (I am one) but all it proves is that comparing any two genomes one finds reused genes and brand new taxa-specific genes. You can interperet that as macroevoltuion but the data is completely consistent with the creaiton of genomes followed by allelic plasticity and gene losses and duplicaitons.
M: Duplications are NOT always allelic. The hox clusters do not just duplicate the same functions. Amphioxus has one cluster and cannot develop the body plan of say Drosophila. Flies can because of the novel functions of the newly duplicated Hox genes.
But you have simply assumed that these organisms have evolved! I don't believe those Hox genes evolved from each other. You have not shown that!
M: Hmm then God sure was constrained to making the duplications etc all tracable by identity by descent i.e. phylogenetics as opposed to the poof bang it is there hypothesis. So it is not only my assumption. For most duplications etc. I can find the original i.e. retrotransposon induced mutation trace back to specific classes of HERVS etc. Not de novo poof bang. And lots of new gene families have been evolved...in fact all of them.
We have no probelm with horizontal transfer. But that does not mena that is how most funcitonal genes ended up in each organism.
M: "regardless of how gravity works it is an empirical fact" is your agrument for gravity???? Nobody has "proved" any science. There is a theory of gravity and a theory of evolution.
I'm sure you are aware that there are theories and theories.
More independent disciplines support the theory of evolution than the theory of gravity! And that life re-uses old pieces as you put it works against macroevolution how? It works against creation as you would expect the creator to poof bang the new piece into existenct perfectly rather than generating suboptimal parts from duplicated or co-opted functions of an older system that then need to be fine tuned by natural selection.
But all of your evidences are for allelic evolution. 99% of the human genome has appeared 'poof' from nowhere along your suppossed evolutionary tree. Simple bacteria only have about 100 gene families. The evidence very well supports the idea that funcitonal sub-networks of genes are conserved together. There is a logical reason for the reuse becasue they are parts of subsystems.
M: My example flew over your head TB. I was pointing out the logic that you use regarding creation using a protein conformation change example. I was not equating prion pathogenesis with the origin of life. But more importantly, you ignored my first sentence.."However, you never provide said evidence except to say you merely believe it is so." If your "belief" is a possibility I will ask you to present the following:
1) testable hypothesis
2) supporting data
3) predictions of this hypothesis
4) is the hypothesis falsifiable.
What evidence can any of us provide but the genomes and today's processes? Together these support the idea of kinds that vary within allelic limits. Your idea that all of the gene families arose is the fairy tale Mammuthus. Our idea arises naturally, yours needs the shoe-horn.
We do plenty of 1-4, you just view the data with blinkers I'm afraid.

This message is a reply to:
 Message 99 by Mammuthus, posted 12-12-2002 5:10 AM Mammuthus has replied

Replies to this message:
 Message 101 by Mammuthus, posted 12-12-2002 6:55 AM Tranquility Base has replied
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Tranquility Base
Inactive Member


Message 103 of 238 (26572)
12-14-2002 6:11 AM
Reply to: Message 101 by Mammuthus
12-12-2002 6:55 AM


Mammuthus
OK, let's look at these one at a time (I'm about to decorate our tree so I've only got a couple of minutes):
Your Mazumder et al example:
3' Cyclic nucleotide phosphodiesterases are enzymes that catalyze at least two distinct steps in the splicing of tRNA introns in eukaryotes. Recently, the biochemistry and structure of these enzymes, from yeast and the plant Arabidopsis thaliana, have been extensively studied. They were found to share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT and the vertebrate myelin-associated 2',3' phosphodiesterases. Using sensitive sequence profile analysis methods, we show that these enzymes define a large superfamily of predicted phosphoesterases with two conserved histidines (hence 2H phosphoesterase superfamily). We identify several new families of 2H phosphoesterases and present a complete evolutionary classification of this superfamily. We also carry out a structure- function analysis of these proteins and present evidence for diverse interactions for different families, within this superfamily, with RNA substrates and protein partners. In particular, we show that eukaryotes contain two ancient families of these proteins that might be involved in RNA processing, transcriptional co-activation and post-transcriptional gene silencing. Another eukaryotic family restricted to vertebrates and insects is combined with UBA and SH3 domains suggesting a role in signal transduction. We detect these phosphoesterase modules in polyproteins of certain retroviruses, rotaviruses and coronaviruses, where they could function in capping and processing of viral RNAs. Furthermore, we present evidence for multiple families of 2H phosphoesterases in bacteria, which might be involved in the processing of small molecules with the 2',3' cyclic phosphoester linkages. The evolutionary analysis suggests that the 2H domain emerged through a duplication of a simple structural unit containing a single catalytic histidine prior to the last common ancestor of all life forms. Initially, this domain appears to have been involved in RNA processing and it appears to have been recruited to perform various other functions in later stages of evolution.
These proteins form a 'super family'. As such they share the same fold and the same chemical funciton. It wouldn't even surprise me for these proteins to have drifted away from a common anscestor if indeed (i) sufficent time had occurred or (ii) these organisms were related by evolution.
But you have simply assumed both (i) and (ii), not shown them. So your evidence is neither non-allelic (these could be heavily mutated alleles!) and only proves evolution if you already believe it.
The data is perfectly compatible with separate creation. The distant 'profile similarity' (let me know if you want me to explain that bioinforamtics to you), even from an evolutionary point of view, could be physico-chemical (ie convergent or separately created) rather than divergent evolution. Two proteins with the same fold can have totoally different sequences but the same 'profile' and catalytic residues without being related by evolution. Go look up the definition of a superfamily to prove it to yourself.
Mammuthus, unless I have missed something, this ref has zero relevance to proving that evolution is capable of generating gene types that are non-allelically related. It would help the discussion if you at least explained what you think its relevance is rather than simply pasting abstacts.
[This message has been edited by Tranquility Base, 12-14-2002]

This message is a reply to:
 Message 101 by Mammuthus, posted 12-12-2002 6:55 AM Mammuthus has replied

Replies to this message:
 Message 104 by Mammuthus, posted 12-15-2002 6:25 AM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 106 of 238 (26668)
12-15-2002 6:43 PM
Reply to: Message 104 by Mammuthus
12-15-2002 6:25 AM


Mammuthus
Mammuthus writes:
The data from this paper show an extremely well conserved functional domain that is part of a superfamily of proteins indicating that the family evolved from a common ancestor.
This is precisely where you do the jumping to conclusions. You simply have blinkers on. The data is equally conmpatible with God reusing a design.
If you deny identity by descent you cannot believe in the concept of a protein superfamily. To be a "family" means that they have to show similarity by common ancestry.
Correct. If I had my way I would call these protein supergroups or something lke that. Anything that categorizes could be either a 'family' or a 'group'. Semantics cannot help anyone here.
'Superfamily' is an evolutionary misnomer anyway. Members of a superfamily are not necessarily related via divergent evolution even by the evolutionary definiton of superfamily. The term 'family' here simply means 'group'.
Then there should be no reason for KRAB memebers to show ANY sequence similarity. You could get the function multiple ways so why are KRAB proteins in one species more similar to KRAB proteins in the related species than in very distant relatives?
Why do you insist that God could not reuse designs just as a human engineer would?
What a bunch of nonesense TB...so you god follows the rules of chemistry but then ditches the observable rules of transmission genetics? Your independent creation schtick is hardly parsimonious..it requires ignoring a huge amount of data to believe in.
Could you explain what you're getting at here?
TB:
Two proteins with the same fold can have totoally different sequences but the same 'profile' and catalytic residues without being related by evolution. Go look up the definition of a superfamily to prove it to yourself.
M: However, that is not what I posted..and neither are the KRAB family, HOX, HERVs etc.
What's your point precisely? My point is simply that protein superfamilies have certain vauge 'profile' similarities that could be any of:
(i) Convergent evolution
(ii) Divergent evolution
(iii) Creation
I will point out TB, that you almost never post a single reference that supports you claim that I could read. I don't mean creationist literature. I mean, post a section of a genetics, genomics, zoological, or paleontological article or book that you think is a good example of creation and we can discuss it. As to my posting abstracts, I posted references that I felt dealt with the subject at hand. If you don't understand them or some part of them let me know. I thought the KRAB article and the tunicate genome sequencing article are pretty self explanatory.
I haveb't addressed your KRAB stuff. I'm talking it one abstract at a time and your first abstract was compeletley irrelevant. On the surface it kindo f sounds relevant, but in the end it has no relevance as I have explained.
The phophodiesterase article was just to show that evolution works by exon shuffling, duplication, deletion, di-tri-tetra nucleotide expansion etc etc to generate novelty. Horizontal transfer is another mechanism.
Guess what, I agree! If genomes arrived by evoltuion then one mechanism is shuffling, duplication etc. But the evidence that exists only demonstrates allelic examples. No-one has shown where distinct protein families come from. All you guys ever whow is that if evoltuion aoccurred it must have had such and such features. We agree! What we point out is that your mistake is your initial assumption that macroevolution has occurred.
Syncytin was originally an envelope protein for a retrovirus...now it initiates syncytiotrophoblast fusion for Old World Monkey and Great Ape placental development.
But that's simply your assumption. God could have inserted the gene in the genomes of all sorts of organisms of course as he could have for the entire proteomes. EDIT: see below, now that I have read the remainder of your post.
It is all consistent with the fact that in sexually reproducing animals you inherit you genes from your parents who inherited theirs from their parents all the way back to the common ancestor of all living things.
Yes it's consistent. It's also consistent with God creating kinds and then letting them go for it within allelic boundaries as one would expect from an engineering point of view.
[This message has been edited by Tranquility Base, 12-16-2002]

This message is a reply to:
 Message 104 by Mammuthus, posted 12-15-2002 6:25 AM Mammuthus has replied

Replies to this message:
 Message 108 by Mammuthus, posted 12-16-2002 4:24 AM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 107 of 238 (26694)
12-16-2002 1:00 AM
Reply to: Message 101 by Mammuthus
12-12-2002 6:55 AM


Mammuthus
Let's now move to your Looman et al ref:
Mol Biol Evol 2002 Dec;19(12):2118-30
KRAB Zinc Finger Proteins: An Analysis of the Molecular Mechanisms Governing Their Increase in Numbers and Complexity During Evolution.
Looman C, Abrink M, Mark C, Hellman L.
Kruppel-related zinc finger proteins, with 564 members in the human genome, probably constitute the largest individual family of transcription factors in mammals. Approximately 30% of these proteins carry a potent repressor domain called the Kruppel associated box (KRAB). Depending on the structure of the KRAB domain, these proteins have been further divided into three subfamilies (A + B, A + b, and A only). In addition, some KRAB zinc finger proteins contain another conserved motif called SCAN. To study their molecular evolution, an extensive comparative analysis of a large panel of KRAB zinc finger genes was performed. The results show that both the KRAB A + b and the KRAB A subfamilies have their origin in a single member or a few closely related members of the KRAB A + B family. The KRAB A + B family is also the most prevalent among the KRAB zinc finger genes. Furthermore, we show that internal duplications of individual zinc finger motifs or blocks of several zinc finger motifs have occurred quite frequently within this gene family. However, zinc finger motifs are also frequently lost from the open reading frame, either by functional inactivation by point mutations or by the introduction of a stop codon. The introduction of a stop codon causes the exclusion of part of the zinc finger region from the coding region and the formation of graveyards of degenerate zinc finger motifs in the 3'-untranslated region of these genes. Earlier reports have shown that duplications of zinc finger genes commonly occur throughout evolution. We show that there is a relatively low degree of sequence conservation of the zinc finger motifs after these duplications. In many cases this may cause altered binding specificities of the transcription factors encoded by these genes. The repetitive nature of the zinc finger region and the structural flexibility within the zinc finger motif make these proteins highly adaptable. These factors may have been of major importance for their massive expansion in both number and complexity during metazoan evolution.
Much of this is again simply assumed. On the other hand I agree that genes can duplicate and mutate. Some of the members of this family probably have their origin in duplicaiton. But they are all still transcription factors and the protein folds are still the same.
You also said:
Sycytin is a HERV-W envelope gene that causes syncitotrophoblast fusion critical in the formation of the placenta. It only does this in Old World Monkeys and the great apes as other primates do not contain this class of HERV. They also require syncitiotrophoblast fusion but it is carried out by an unrelated gene.
I am quite prepared to agree with you that this sort of 'non-homologous replacement' as it is called has occurred in nature. It's clear that this is simply an example of horizontal transfer and that it does not explain how the gene itself arose.
Did it create a novel subsystem? No the system was working nicely. Then the gene hoped into the genome from elswhere and was able to funciton in parallele with the existing gene yielding redundancy. Then one or other gene, in this case the one that had been arond longer, mutated and becomae non-funtional. I agree that that is what may have occurred in this case. But the funciton already pre-existed as did the non-homologous, but similarly functioning, genes.
So that is definitely non-allelic, I'll grant that. But it does not represent the origin of a new gene family or new subsytem. Both were pre-exisiting.
[This message has been edited by Tranquility Base, 12-16-2002]

This message is a reply to:
 Message 101 by Mammuthus, posted 12-12-2002 6:55 AM Mammuthus has replied

Replies to this message:
 Message 109 by Mammuthus, posted 12-16-2002 4:35 AM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 115 of 238 (26862)
12-16-2002 5:48 PM
Reply to: Message 108 by Mammuthus
12-16-2002 4:24 AM


Mammuthus
Mammuthus writes:
So you do not believe that you pass on any genetic material to your offspring i.e. they are genetically no more related to you than to a housefly? That is what you have to accept in order for you to claim I have blinkers on and that the proteins are similar, can be grouped by related organisms, have conserved functions.
There's nothing wrong with your POV except that it is only one interpretation, hence the blinkers.
There is no reason for there to be homology of systematic relevance if the proteins are not similar by descent.
If God created the genomes the sequence homology could be presnet due to creative reuse. And superfamily simlarity is not necessarily at the sequence level (see next).
TB:
'Superfamily' is an evolutionary misnomer anyway. Members of a superfamily are not necessarily related via divergent evolution even by the evolutionary definiton of superfamily. The term 'family' here simply means 'group'.
M: Why would you call it a group in any case if you don't believe the proteins are related? You are not being consistent.
The proteins are related by 3D structure, that's why they have the same seqweunce profile. A superfmaly is a structural family that does not need to be related deivergenetly. Trust me on this one will you. It's a mainstream definition! I teach it in my lectures.
You were stating that the rules of chemistry are inviolable and are followed for whatever reason by your god. But then against the rules governing inheritence and population genetics, you claim that there is no identity by descent but rather constant independent creation events that you have no evidence for. How is that a parsimonious or even a testable hypothesis? And why should god obey the rules of physics and chemistry but then ignore the observable rules of inheritence which is ultimately also chemistry?
Nature does obey the rules of genetics. But if God created kinds the rules of genetics have been only in action since the gneomes were created. You see tantalizing evidence of common descent in the homologous genes but it never bnothers you that tens of thousands of new unrealted genes have appeared since the simplest bacteria.
All you are doing is putting a slant on reuse. I am putting the other slant on it. Over time one or other of our viewpoints may be ruled out or become hard to justify (as future genomes turn up). Currently both are compatible with the data.
TB:
(i) Convergent evolution
(ii) Divergent evolution
(iii) Creation
M: Why 3? Convergent evolution (I am not sure what you mean by divergent evolution) but anyway, evolution predicts similarity by because of common ancestry. Why would creation? How would you test it? Created by who? If you answer that how do you know it was not created by something else? What created the creator?...
Divergent evoltuion is evolution that leaves undoubted signatures of common descent. For us it is simply reuse of a gene. As you probably know, convergent evolution is a stumbling upon a similar feature without evidence of common descent (for that feature). For us it is resuse of a protein fold without the sme sequence.
M: Umm what exactly don't you get TB? If amphioxus has one hox cluster which developmentally restricts it to a very basic body plan and then you see Drosophila with a more complex body plan and more hox clusters and mammals with 4 hox clusters and yet more complicated body plans. The devo's have mapped out the transcription profiles particularly in drosophila for the significance in change in expression upon morphology even among fairly distant related species. How is this not macroevolution? If the duplicates, HERVs, shuffled exons are exclusive to a group and have some impact on the morphology, behavior etc on that group that makes it distinct, that is macroevolution. You are really not clear on what you want in terms of information. When you argued that bacteria have no evidence of hemoglobin I showed that they do and that it has a different function in bacteria. Hemoglobin evolution is macroevolution as well between bacteria and multicellular organisms.
I get all of that. What you keep forgeting is that in additon to the generation of new paralogs new taxa systematically discover new protein families and systems that did not exist before.
M: We know the how and why HERVs transpose just like other proviruses. There have been direct observations as well as experimentall induced cases of retrotransposition. The HERV-W endogenous retroviruses are only known from Old World Monkeys and Great Apes from an infection of the last common ancestor of all. Given that we know how and why retrotranposons work, we know the systematics of primates and can perform tests of the relevant hypothesis involved, what compelling reason should I have for accepting your assertion that none of this occurred by the known natural mechanisms like other HERVs but is a case of "god did it"? I can test retrotranposition mechanisms..I can even find the most closesly related HERV envelope gene to syncytin (well I dont have to, it was alread published)...can you show any positive evidence that all of this entire field of inquiriy (which includes HIV research as it is a retrovirus to) is complete bullshit and that your god did it? Please provide some positive evidence for it.
I have no problem with horizontal transfer as I have said on many occasions. It does not account fo the origin of any gene family.
TB:
Yes it's consistent. It's also consistent with God creating kinds and then letting them go for it within allelic boundaries as one would expect from an engineering point of view.
M: How so? Please detail how it is consisten with god creating kinds and what testable hypothesis there is that would support this view. Also list the kinds of experimental evidence you would gather for god creating kinds and the predictions you would make based on the testable hypothesis.
The genomes are undoubtedly consistent wiht God creating x thousand gneomes and letting them evolve since then via all the mechanisms of plasticity that you believe in. God created fully working genomes that have evolved allelically and via horizontal transfer and via gene loss. It is perfectly conpatibel with thegenome projects. You just don't like it. You insist on reading the reuse as common descent over time. It could simply be reuse by God.
Experiments? The data comes from the genome projects. If the idea of kinds is true we should be able to catalog life into kinds from genomes. The members of each kind will be distinguished by allelic differences and relative losses. Kinds will be differentiable by relative gene family and paralog gains. Because gene losses vs gains aren't always distinguishable it may not always be possible to identify kinds in this way. Hence it may be difficult to objectively distinguish between the creation and evolution models, as we are finding, becasue the actions of history are not always carefully recoded for us in the genomes.
[This message has been edited by Tranquility Base, 12-16-2002]

This message is a reply to:
 Message 108 by Mammuthus, posted 12-16-2002 4:24 AM Mammuthus has replied

Replies to this message:
 Message 120 by Mammuthus, posted 12-17-2002 3:56 AM Tranquility Base has not replied

  
Tranquility Base
Inactive Member


Message 116 of 238 (26865)
12-16-2002 6:04 PM
Reply to: Message 112 by nator
12-16-2002 10:19 AM


I think AIGs article of faith is a 'necessary evil'. There are so many flavours of OEC and YEC that they want to beable to state how many 'real' YECs they have on the books.
That does not stop a non-member from publishing in the journal however. All it does is stop someone being a member. If I were running the society I would also create an 'observer' membership for the 'unsure', OEC and atheist categories.

This message is a reply to:
 Message 112 by nator, posted 12-16-2002 10:19 AM nator has replied

Replies to this message:
 Message 117 by nator, posted 12-16-2002 7:00 PM Tranquility Base has replied

  
Tranquility Base
Inactive Member


Message 118 of 238 (26875)
12-16-2002 7:02 PM
Reply to: Message 117 by nator
12-16-2002 7:00 PM


They are not just doing science Schraf. I'll agree with that. But an organization that does things other than science can also do science.

This message is a reply to:
 Message 117 by nator, posted 12-16-2002 7:00 PM nator has replied

Replies to this message:
 Message 121 by nator, posted 12-17-2002 9:31 AM Tranquility Base has replied

  
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