I think the problem here is the term "realistic".
I take that to mean, "happening normally" outside of the lab.
Forget biology for a second, let's talk about something very observable, like simple physics.
Is it realistic that two perfectly shaped spheres of differing sizes and masses would fall from the same height at the same time?
Is it realistic that a perfect lever would exist balancing a heavy object near to the fulcrum and a lighter object further away?
No, but these experiments are done to demonstrate the principles or to better understand that mechanics of simple physics.
Would a single colony of fruit flies, all decended from the same parents, be seperated into two groups of equal number, then one of those groups would be blasted with radiation?
Unlikely. Does it help us to better understand mutation? Certainly.