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Again, this isn't ReMine's baby, its Haldane's.
False. The idea that the substitution rate typically refers to single nucleotides is ReMines - not Haldanes.
And Haldanes numbers were based on assumptions that are certainly not guaranteed to hold (e.g. the assumption that all selection is "hard" selection)
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Well, that's a good question. According to evolutionary geneticists, each of those substitutions is typically represented as one nucleotide, not thousands of nucleotide differences.
That isn't even what ReMine says ! If you can really show me an evolutionary geneticist saying that we should count a large insert or transposition as a single nucleotide change - when in fact it is many - please go ahead. Personally I just think you are spouting words you don't understand.
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The odds of having as much as 84 nucleotide change is an astronomical figure that greatly exceeds 1050, which is mathematically representative of "absolute zero."
A simple case of garbage in, garbage out. The fact that you don't explain what you are calculating or how just makes it nonsense.
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ReMine goes over this, because you aren't the only one to offer gene clusters as a possible solution, such as pleiotropy or really anything considered polygenous
But I wasn't offering a solution or referring to gene clusters or pleiotropy. I was simply asking how you could measure how you could measure the number of nucleotide substitutions when a gene is polymorphous to start with (i.e. has more than one allele). And you don't offer a real answer, instead you ustt quote ReMine.