No mutations in neutral gene-parts?

Peter Borger. You told me that the ZFY-gene lacks mutations in neutral (not so important) parts of the gene, while it should have been lots of them gathered in millions of years. Do you have any information about this or about any other gene in a similar situation.

Hi CM,ZFY can be explained by the GUToB, not by evolutionary theories.You can find it here:http://EvC Forum: Dr Page's best example of common descent easily --and better-- explained by the GUToB -->EvC Forum: Dr Page's best example of common descent easily --and better-- explained by the GUToBHowever, I think you refer to the ZFX gene. The region is the same in almost all primates studied (for about 25 million evolutionary years if I recall properly). ZFX can be explained by GUToB, though.Abstract:Mol Cells 2000 Oct 31;10(5):512-8 Related Articles, LinksEvolution of the X-linked zinc finger gene and the Y-linked zinc finger gene in primates.Kim HS, Takenaka O.Division of Biological Sciences, College of Natural Sciences, Pusan National University, Korea. khs307@hyowon.cc.pusan.ac.krWe have sequenced the partial exon of the zinc finger genes (ZFX and ZFY) in 5 hominoids, 2 Old World monkeys, 1 New World monkey, and 1 prosimian. Among these primate species, the percentage similarities of the nucleotide sequence of the ZFX gene were 96-100% and 91.2-99.7% for the ZFY gene. Of 397 sites in the ZFX and ZFY gene sequences, 20 for ZFX gene and 42 for ZFY gene were found to be variable. Substitution causes 1 amino acid change in ZFX, and 5 in ZFY, among 132 amino acids. The numbers of synonymous substitutions per site (Ks) between human and the chimpanzee, gorilla and orangutan for ZFY gene were 0.026, 0.033, and 0.085, respectively. In contrast, the Ks value between human and hominoid primates for the ZFX gene was 0.008 for each comparison. Comparison of the ZFX and ZFY genes revealed that the synonymous substitution levels were higher in hominoids than in other primates. The rates of synonymous substitution per site per year were higher in the ZFY exon than in the SRY exon, and higher in the ZFY exon than in the ZFY intron, in hominoid primates.Best wishes,
Peter

I took the sequence-part of ZFX and ZFY that NCBI has of the dog, lemur, gibbons, apes and man and aligned them. ZFY showed a good gradual change when I compared man with the apes, gibbons, lemur and the dog. ZFX showed a slower mutation rate than ZFY. The dog differed about 96%(I will tell the exact percentages when I come home) but the gibbons and the apes differed with 99,7 % from man (I didnt check the chimp though)This might be very well known to all of you. Would this mean that ZFX produces a good working protein and are very sensitive for changes and that zink finger proteins from y-chromosomes of these spieces doesnt work or are switched off?

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("ZFX and ZFY" at http://EvC Forum: ZFX and ZFY -->EvC Forum: ZFX and ZFY)
Therefore this topic is closed.Adminnemooseus------------------
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