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Author Topic:   Guess they cured cancer
RAZD
Member (Idle past 1431 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 16 of 44 (381399)
01-30-2007 8:45 PM
Reply to: Message 11 by Coragyps
01-30-2007 8:15 PM


... dichloroacetic acid itself, like its mono- and tri-chloro cousins, is pretty good tear gas if you get ahold of the straight stuff.
So then I need to get involved in some old-fashioned 60's style demonstrations ... ???
( - that stuff was nasty)

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kuresu
Member (Idle past 2539 days)
Posts: 2544
From: boulder, colorado
Joined: 03-24-2006


Message 17 of 44 (381400)
01-30-2007 8:47 PM
Reply to: Message 14 by johnfolton
01-30-2007 8:30 PM


mind staying on topic? my sig is not the topic of this thread.
better yet, how about responding to the point I raised?

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Fosdick 
Suspended Member (Idle past 5526 days)
Posts: 1793
From: Upper Slobovia
Joined: 12-11-2006


Message 18 of 44 (381407)
01-30-2007 9:03 PM
Reply to: Message 6 by Trixie
01-30-2007 6:30 PM


Re: Promising
Trixie wrote:
Sounds like good news, but I'd like to know the pharmacokinetics. I'd be concerned about cells in the centre of very large tumours. If they aren't getting enough oxygen, then the flow of blood-borne substances must be reduced. Can the molecule manage to be delivered to cells in the centre of a tumour in sufficient amounts?
I'm going to do a bit of digging on this to see what I can find. As a smoker for 31 years I'm very interested. And yes, I am kicking the habit soon.
I have to wonder about what is genetically predisposed vs. what is caused environmentally, as in the case of smoking. In my model of enduring health stress is an important factor. Stress will bring the worst out of your genes”a principle I have come painfully to understand. In this regards I think smoking helps to reduce stress for a lot of good people. Who ever asks about the health benefits of smoking? (Because it's not politically correct?)
”Hoot Mon

This message is a reply to:
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Replies to this message:
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Omnivorous
Member
Posts: 3988
From: Adirondackia
Joined: 07-21-2005
Member Rating: 7.0


Message 19 of 44 (381442)
01-30-2007 11:38 PM
Reply to: Message 1 by Dan Carroll
01-30-2007 5:39 PM


Dan Carroll writes:
The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.
Sounds like it is already legally available to any physician who wishes to use it off-label.
If I were a cancer patient who had failed available protocols, I'd certainly find a doctor willing to give it a whirl. I suspect we'll have lots of data real soon.

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sidelined
Member (Idle past 5934 days)
Posts: 3435
From: Edmonton Alberta Canada
Joined: 08-30-2003


Message 20 of 44 (381444)
01-30-2007 11:44 PM
Reply to: Message 1 by Dan Carroll
01-30-2007 5:39 PM


Dan Carroll
If you want I can take a run over to the U of A across the river and see if we can get your name into the clinical trials. How 'bout you get your nasty habit up to 6 packs a day and we'll see what we can do for you eh?

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nator
Member (Idle past 2196 days)
Posts: 12961
From: Ann Arbor
Joined: 12-09-2001


Message 21 of 44 (381445)
01-30-2007 11:50 PM
Reply to: Message 1 by Dan Carroll
01-30-2007 5:39 PM


quote:
Look, I'm a ten-year-plus smoker. Can somebody who knows medicine please go ahead and tell me if this is legit or not before I start wildly pumping my fist in the air, laughing at cancer, and screaming, "USA! USA! USA!"?
Oh, don't worry Dan.
It's still possible for you to have heart disease and emphysima on your future health dockett!

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nator
Member (Idle past 2196 days)
Posts: 12961
From: Ann Arbor
Joined: 12-09-2001


Message 22 of 44 (381447)
01-30-2007 11:53 PM
Reply to: Message 7 by AnswersInGenitals
01-30-2007 6:55 PM


quote:
Given that someone who has died of cancer is somewhat less likely to be reproductively successful than some who is still living,
People have usually raised their children before they die of cancer.

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nator
Member (Idle past 2196 days)
Posts: 12961
From: Ann Arbor
Joined: 12-09-2001


Message 23 of 44 (381449)
01-30-2007 11:59 PM
Reply to: Message 18 by Fosdick
01-30-2007 9:03 PM


Re: Promising
quote:
In this regards I think smoking helps to reduce stress for a lot of good people.
What brings on the stress?
The withdrawl symptoms of nicotine!
When people first begin to smoke, it is not a stress-reducer, but a stimulant. They get a buzz from it.

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Dr Jack
Member
Posts: 3514
From: Immigrant in the land of Deutsch
Joined: 07-14-2003
Member Rating: 8.4


Message 24 of 44 (381457)
01-31-2007 5:39 AM
Reply to: Message 12 by crashfrog
01-30-2007 8:16 PM


There is: Amygdalin - Wikipedia (or, at, least there is something some people are calling B17)
Edited by Mr Jack, : Clarification.

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Doddy
Member (Idle past 5936 days)
Posts: 563
From: Brisbane, Australia
Joined: 01-04-2007


Message 25 of 44 (381459)
01-31-2007 6:53 AM
Reply to: Message 23 by nator
01-30-2007 11:59 PM


Re: Promising
In this regards I think smoking helps to reduce stress for a lot of good people.
When people first begin to smoke, it is not a stress-reducer, but a stimulant. They get a buzz from it.
You're both right. Nicotine does act on certain acetylcholine receptors, leading to the release of adrenaline (causing excitation and stimulation), but it also inhibits the breakdown of dopamine, causing relaxation and pleasure.

"Der Mensch kann was er will; er kann aber nicht wollen was er will." (Man can do what he wills but he cannot will what he wills.) - Arthur Schopenhauer

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Trixie
Member (Idle past 3732 days)
Posts: 1011
From: Edinburgh
Joined: 01-03-2004


Message 26 of 44 (381462)
01-31-2007 7:17 AM
Reply to: Message 18 by Fosdick
01-30-2007 9:03 PM


Genetic basis of cancer
All cancers involve a genetic component, namely one or more mutations which allow the cells to divide out of control. If you're lucky, the mutated cell will be recognised by the body as "foreign" and disposed of by the immune system. However, if the mutation isn't recognised the mutated cell will continue to thrive. The immune system can be affected by stress and environmental factors and this can lead to a reduction in it's efficiency.
What causes the mutations in the first place is where environment plays a major role. Substances like tobacco smoke contain chemicals which can alter DNA i.e., cause mutations.
In rare cases a persion can be said to be predisposed to cancer, for example retinoblastoma, but in these cases they are born with a mutation in one copy of the gene, so a single mutation in the "back up" copy will cause malignancy whereas those born with two functional genes would have to have both copies mutated for the malignancy to develop. In the case of breast cancer, certain alleles of the bcr gene can predispose to cancer, but again additional mutation is necessary. So, even though there may be a predisposition, the bottom line is that mutation is characteristic of tumorigenesis.
For a reasonable introduction to the genetic basis of cancer have a look at this site
http://www.studentbmj.com/issues/05/02/education/52.php
There are ABSOLUTELY NO health benefits to smoking with the exception of relief of nicotine withdrawal symptoms so it's a bit circular.

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Larni
Member
Posts: 4000
From: Liverpool
Joined: 09-16-2005


Message 27 of 44 (381468)
01-31-2007 7:46 AM
Reply to: Message 18 by Fosdick
01-30-2007 9:03 PM


Re: Promising
Hoot Mon writes:
In this regards I think smoking helps to reduce stress for a lot of good people.
Smoking does not reduce stress. Nicotinamides cause autonomic arousal. The reduction in stress is because we percieve smoking as a safty behaviour.
Also when we draw we take a nice deep breath and let it out. This is typical of the type of relaxation breathing techniques one would use when trying to reduce anxiety levels.
The only good thing about fags I can think of is that it has a slight laxative effect.

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Larni
Member
Posts: 4000
From: Liverpool
Joined: 09-16-2005


Message 28 of 44 (381470)
01-31-2007 7:50 AM
Reply to: Message 1 by Dan Carroll
01-30-2007 5:39 PM


It seems legit, but there is a simliar molecule with at least an identical effect:
Artical writes:
Anyway, you’ve learned more about DCA than you care to, or need to, know. That’s because there is another small molecule that deserves more attention. Like DCA, it is a small molecule that can enter the cell nucleus and switch genes on or off. It is perceived by the body as a toxin, but actually is non-toxic, and it is very stealth, it can penetrate any resistant cancer cell. It works in a similar manner to DCA by inducing cancer cell death (apoptosis). The molecule is resveratrol, known as a red wine molecule. Resveratrol appears to kill off cancer cells by depolarizing (demagnetizing) mitochondrial bodies within tumor cells.
Resveratrol is 100 anti-cancer drugs in one. Resveratrol works in so many ways to block cancer, researchers can’t find a cancer-promotion pathway it doesn’t inhibit. It is virtually non-toxic since, after oral ingestion, it is quickly metabolized by the liver, attached to a detoxification molecule called glucuronate, which renders it harmless, though biologically inactive, at least for a time.
About the Latest Cancer Cure - LewRockwell LewRockwell.com

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Doddy
Member (Idle past 5936 days)
Posts: 563
From: Brisbane, Australia
Joined: 01-04-2007


Message 29 of 44 (381472)
01-31-2007 8:04 AM
Reply to: Message 27 by Larni
01-31-2007 7:46 AM


Re: Promising
Smoking does not reduce stress.
It does. An enzyme called MAO (mono-amine oxidase) is inhibited by smoking (although it appears that other components of tobacco smoke than nicotine are responsible). This enzyme deactivates neurotransmitters such as dopamine, so inhibiting its action will cause an increase in dopamine, which relieves stress.
Additionally, stimulation of some nACR (nicotinic acetylcholine-receptors) can cause the downstream release of dopamine and endomorphines.
The psychoactive effects of smoking can be divided into two phases - first there is the arousal phase, then the endorphin release. Some studies even suggest that smokers unconsciously pattern their smoking to enhance which part of the biphasic pattern they desire.

"Der Mensch kann was er will; er kann aber nicht wollen was er will." (Man can do what he wills but he cannot will what he wills.) - Arthur Schopenhauer

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Phat
Member
Posts: 18335
From: Denver,Colorado USA
Joined: 12-30-2003
Member Rating: 1.0


Message 30 of 44 (381474)
01-31-2007 8:08 AM
Reply to: Message 1 by Dan Carroll
01-30-2007 5:39 PM


Common sense Cancer cures
Dan Carroll writes:
(From article)Paul Clarke, a cancer cell biologist at the University of Dundee in the UK, says the findings challenge the current assumption that mutations, not metabolism, spark off cancers. “The question is: which comes first?” he says.
Green Tea has been said to dramatically reduce the reproductive rates of cancer cells, but I don't have solid research at my fingertips. What I have read, however, seems to generally agree that Cancer cannot live in the presence of adequate oxygen. So circulation is one key. Another key is being able to get in to those pesky tumors and quit leaving places for damaged cells to hide and grow. Expose all the cells, I say!
AbE: Oh Oh.... I also remember reading that when a person is opened up during an operation, the cancer grows quicker. Would that be due to oxygen exposure???
Edited by Phat, : No reason given.

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