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Author Topic:   Irreducible complexity at the microscopic level
Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 16 of 27 (426927)
10-09-2007 4:20 AM
Reply to: Message 10 by Kitsune
10-09-2007 1:53 AM


Fom what I could gather, signalling molecules are part of genes.
Absolutely not. what many signalling molecules are is the product of genes.
One big problem with this approach of yours is that the term 'signalling molecule' can refer to a huge range of things. Hormones are signalling molecules, growth factors and many other proteins are signalling molecules even proteins attached to the outside of the cell can be signalling molecules.
Add to this that arguably any number of proteins involved in the signalling cascade once a signal from outside the cell has been received could be considered 'signalling molecules' and you have a vast array of possible elements.
The simplest sort of signalling is that seen with steroid hormones. Because they are lipophilic these hormones can easily cross the cell membrane and meet up with steroid receptor proteins which carry them into the nucleus and which can bind to specific regions of the nuclear DNA and which behave differently in the presence or absence of hormones. In some cases the receptors actually stay in the nucleus and the hormone passes through the nuclear membrane on its own as well.
Other types of signalling are considerably more complex and rely on cascades of proteins being activated to relay a signal from the cell surface to the activation of proteins affecting transcription in the nucleus. These cascades can involve dozens of proteins, one well studied example is the MAP kinase signalling pathway.
I don't see any similarity to a computer myself, but then I know a lot more about biology than I know about computers. The whole encoding-decoding thing seems to be completely missing. The only obvious candidate for encoding-decoding anywhere in the system is the transcription and translation of mRNA.
Perhaps if you are thinking in a developmental context you are considering the transmission of what is called positional information as a form of encoding-decoding. Positional information is the term given to the variety of factors acting upon a particular set of cells in a developing embryo which lead to it developing into a particular tissue. The simplest way of conveying positional information is a simple gradient of a signalling molecule. Different levels of receptor activation lead to the activation of different genes within the cell causing cells closer to the signal source to have a different character to those further away, the classic illustration of this is Lewis Wolpert's 'French Flag' model.
TTFN,
WK
Edited by Wounded King, : No reason given.

This message is a reply to:
 Message 10 by Kitsune, posted 10-09-2007 1:53 AM Kitsune has replied

Replies to this message:
 Message 20 by Kitsune, posted 10-09-2007 12:14 PM Wounded King has not replied

  
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