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Author Topic:   Why There Are Two Sexes
molbiogirl
Member (Idle past 2667 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 44 of 63 (446761)
01-07-2008 3:44 AM
Reply to: Message 42 by miosim
01-07-2008 3:15 AM


one daughter cell will properly expressed AB phenotype while another will have blood type phenotype completely suppressed.
Please for the love of god listen to me.
Your model says when a cell divides, there is an active strand and an inactive strand.
From your paper:
In the DNA molecule the genes located on the newly synthesized strand are active and genes located on the complemented strand are blocked from transcription ... Two complementary DNA strands carry unequal amount of genetic information ... The diploid eukaryotic cell has two alleles of each gene, so if two homogenous chromosomes are of the opposite type, at least one allele will be active.
An AB phenotype is impossible using your model. Both sites must be transcribed.
There is no such thing as an AB allele. Got it? There is an A and a B. They are different versions of the SAME GENE. Understand? They have the same location on the chromosome. When the two chromosomes are lined up side by side, they are right next to each other. An A on one strand, a B on the other.
From your conclusion:
We demonstrated the theoretical model in which only one strand of DNA molecule is transcribed.
An AB blood type is impossible.

This message is a reply to:
 Message 42 by miosim, posted 01-07-2008 3:15 AM miosim has replied

Replies to this message:
 Message 45 by miosim, posted 01-07-2008 3:59 AM molbiogirl has replied

  
molbiogirl
Member (Idle past 2667 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 46 of 63 (446763)
01-07-2008 4:19 AM
Reply to: Message 45 by miosim
01-07-2008 3:59 AM


This is a diploid cell, that is has two chromosomes with active/ inactive strand: please include in your analysis a second chromosome also and its possible type.
Every cell in your body is a diploid cell!
Diploid: having two copies of each chromosome. A full set of genetic material, consisting of paired chromosomes one chromosome from each parental set.
The model restricts the phenotype expression due to blocked DNA strand, but only in Haploid cell.
Haploid: having only one copy of each chromosome.
The only haploid cells in your body are gametes (eggs/sperm).
In this cell any of four phenotypes could be expressed: A, B, AB or none.
This does not happen.
You know why it's important to get the correct blood type in a transfusion, right?
Because if you get A or B when you are AB, it can kill you.
You are suggesting that one person expresses multiple blood types.
Wrong wrong wrong wrong wrong.
“Your model says when a cell divides; there is an active strand and an inactive strand.”
This is a diploid cell, that is has two chromosomes with active/ inactive strand.
You do not understand what a chromosome is.
Every cell has 46 chromosomes. 23 pairs.
This is a chromosome pair.
Here is a single chromosome on the left, a chromosome pair on the right.
Here is a closer view.
As you can see, one arm contains 2 strands of DNA.
These are the 23 chromosomes in a diploid cell:
Every cell in your body has a full set of these.
Here is a picture of the location of the ABO gene (the red line) on chromosome 9:
You get one copy of the ABO gene from Mom and one copy from Dad.
Now. Let's apply this to the AB blood type.
If Mom is type A, she can have two genotypes: AA, AO
If Dad is type B, he can have two genotypes: BB, BO
If you are type AB, you got an A from Mom and a B from Dad.
That means that one arm of chromosome 9 has A and one arm of chromosome 9 has B.
Now. Let's discuss the nature of a gene.
A gene is a specific genomic sequence on one strand of DNA. Since DNA is complementary, the other strand has the same sequence, in reverse order (DNA strands run anti-parallel).
That means that one arm of chromosome 9 has two copies of the A gene, one on each strand, and the other arm has two copies of the B gene, one on each strand.
When a cell divides, both strands replicate.
Both strands are functional.
The only known exception to this rule in X chromosome inactivation.
Gene suppression does occur, at the level of transcription or translation. But entire strand suppression does not.
Edited by molbiogirl, : No reason given.
Edited by molbiogirl, : added pic
Edited by molbiogirl, : clarity and more pics

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molbiogirl
Member (Idle past 2667 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 48 of 63 (446771)
01-07-2008 7:07 AM
Reply to: Message 30 by molbiogirl
01-07-2008 12:08 AM


Mea culpa
If an allele (a gene) is present on one strand of DNA and not on the other strand of DNA, that gene can be expressed phenotypically.
For example, if one inherits an A allele from one parent and a B allele from the other, then your blood type will be AB, because both alleles are expressed.
My bad. I should have said chromosome, not strand.

This message is a reply to:
 Message 30 by molbiogirl, posted 01-07-2008 12:08 AM molbiogirl has not replied

Replies to this message:
 Message 49 by miosim, posted 01-07-2008 8:38 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2667 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 50 of 63 (447043)
01-07-2008 8:50 PM
Reply to: Message 49 by miosim
01-07-2008 8:38 PM


M, I give up.
Since you can't see that a person who produced those 4 blood types WOULD BE DEAD, I can't help you.

This message is a reply to:
 Message 49 by miosim, posted 01-07-2008 8:38 PM miosim has replied

Replies to this message:
 Message 51 by miosim, posted 01-07-2008 10:53 PM molbiogirl has not replied
 Message 52 by miosim, posted 01-08-2008 5:44 PM molbiogirl has not replied

  
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