Why There Are Two Sexes

Lets do one step in a time.According to my model, AB phenotype has only one scenario: both homologues chromosomes must be of the same type with the AB genes active. Now, if this cell divides it results in one daughter cell with AB genes active, and another “inverted” cell with completely blocked A or B genes. Is this “inverted” cell bothers you?I am going to work on your next example while you are reading this.Edited by miosim, : No reason given.

While I am reading your post, you can read my.
Just one comment for now:“Your model says when a cell divides; there is an active strand and an inactive strand.”This is a diploid cell, that is has two chromosomes with active/ inactive strand: please include in your analysis a second chromosome also and its possible type. Not as I see it.
The model restricts the phenotype expression due to blocked DNA strand, but only in Haploid cell. Diploid cell is overcomes this restriction. In this cell any of four phenotypes could be expressed: A, B, AB or none.

“at least one allele will be active” means allele A, B or both. Do not worry, I know genetics at least within boundary of this papers. I may misspoke, but you too wasn’t in a gratest shape:“ . they have the same location on the chromosome . ” not on the same but on homologous chromosomes, but I new what you ment. Today is two late and I have to go to work at 6 AM, but tomorrow (evening) can you draw the diagram of diploid cell and demonstrate that this is impossible to have AB blood type per my model and I will prepare my diagram.Thanks a lot,Mark

molbiogirl,I am including the diagram that illustrates my point:

Click here Per my model, independent distribution of chromosomes during mitotic cell divisions yields four types of cells types.Per existing paradigm the cell division yields only identical cells.

molbiogirl: No. Erythrocytes of this person have all opportunity to be of correct type (AB).Try to think of the diploid cell that has only one pair of chromosomes and two alleles A and B of a particular gene.Let call this cell - Erythrocytes only if the combination of its chromosome types leads to expression of both alleles A and B.If during mitotic division the cell inherits chromosome types that lead to expression of allele A, B or None - these cells are not Erythrocytes any more, even their mitotic division may result in more Erythrocytes. This is what proposed mechanism of cell differentiation is about.This is all I can say. I think I need to pose, and try to understand what is wrong with my model or with my explanation.Thank you for trying.Edited by miosim, : No reason given.

molbiogirl,I noticed ambiguity in a way I used the term “genetically active” referencing newly synthesized DNA strands. It may be interpreted that the genes located on this DNA strand are continuously transcribed. In this case, I would understand your comment that
“ . a person who produced those 4 blood types WOULD BE DEAD . ”However what I meant is that this DNA strand is just accessible for transcription but still subjected to routing mechanism of gene regulation.So regardless that my model allows existence of all four cell types in reference to accessibility to genes A, B and AB, the regulatory mechanisms of cell and organism will insure that only AB cell type (Erythrocytes) expresses its phenotype.I wonder if this caused misunderstanding, especially that a few times I explicitly called these cell types as A, B and AB phenotypes, which is incorrect.In my papers, I will change the term “genetically active” to “genetically enable” and will clarify that it means accessibility for transcription by routing mechanisms of gene regulation. Edited by miosim, : No reason given.Edited by miosim, : No reason given.

RAZD,Again, I will not defend Geodakyan’s theories because I know nothing about this area of biology.I accounted Geodakyan’s theories, because I was looking for any glues related to my hypothesis. His theories stroked me with unusual for biological publications internal harmony and boldness. However, because his theories were nothing to do with what I was looking for I didn’t follow and scrutinize them.To be honest, if I would have more time I wouldn’t let you to burry his ideas so easily, because I have more trust in the beauty of his ideas and his talent that in the your argument.But I have no luxury of spare time to investigate Geodakyan’s theories or your claim, and therefore, feel free to talk about Geodakyan’s theories and pretend that you know what you are talking about.But if you want to talk about my hypothesis I will not be silent and may expose not only my lock of competence but yours also.Edited by miosim, : No reason given.Edited by miosim, : No reason given.Edited by miosim, : No reason given.