Understanding through Discussion


Welcome! You are not logged in. [ Login ]
EvC Forum active members: 86 (8951 total)
554 online now:
DrJones*, PaulK (2 members, 552 visitors)
Newest Member: Mikee
Post Volume: Total: 866,808 Year: 21,844/19,786 Month: 407/1,834 Week: 407/315 Day: 3/82 Hour: 0/0


Thread  Details

Email This Thread
Newer Topic | Older Topic
  
Author Topic:   Quick Questions, Short Answers - No Debate
Admin
Director
Posts: 12653
From: EvC Forum
Joined: 06-14-2002
Member Rating: 2.9


Message 61 of 569 (452657)
01-30-2008 10:09 PM
Reply to: Message 59 by New Cat's Eye
01-29-2008 10:42 AM


Catholic Scientist writes:

Weren't you talking about going to dBoard 3.0 sometime before? Did you decide on MySQL instead?

dBoard 2.0, the current installed version, uses MySQL for the member database. dBoard 3.0 will use MySQL for the message database, too. I already have most of the software written and debugged, but I need a large block of free time (weeks) to complete it and then release it.

Yes, the limit should be in the FAQ.


--Percy
EvC Forum Director

This message is a reply to:
 Message 59 by New Cat's Eye, posted 01-29-2008 10:42 AM New Cat's Eye has not yet responded

  
Cold Foreign Object 
Suspended Member (Idle past 1384 days)
Posts: 3417
Joined: 11-21-2003


Message 62 of 569 (453513)
02-02-2008 3:03 PM


Whatever happened to Crashfrog?

Why is Jar banned?

Ray


Replies to this message:
 Message 75 by Taz, posted 02-10-2008 9:08 PM Cold Foreign Object has not yet responded

  
Percy
Member
Posts: 19062
From: New Hampshire
Joined: 12-23-2000
Member Rating: 3.2


Message 63 of 569 (454032)
02-05-2008 9:20 AM


Quick posting test...
Testing...

  
Dr Adequate
Member
Posts: 16107
Joined: 07-20-2006
Member Rating: 8.3


Message 64 of 569 (454036)
02-05-2008 9:41 AM


What Happens When A Ribosome Translates mRNA Lacking A Stop Codon?
What happens when a ribosome translates mRNA lacking a stop codon?

Many thanks to anyone who can tell me.


Replies to this message:
 Message 66 by teen4christ, posted 02-05-2008 2:26 PM Dr Adequate has responded

  
Wounded King
Member (Idle past 2431 days)
Posts: 4149
From: Edinburgh, Scotland
Joined: 04-09-2003


Message 65 of 569 (454038)
02-05-2008 9:48 AM


What's that you say Dr.A?
Dr.A writes:

What Happens When A Ribosome Translates mRNA Lacking A Stop Codon?

Such transcripts are called 'nonstop' and they are targeted for degradation when they cause the ribosome to hang in the absence of a termination codon.

The mechanisms of degradation are different in prokaryotes and eukaryotes.

TTFN,

WK


Replies to this message:
 Message 67 by Dr Adequate, posted 02-07-2008 9:11 AM Wounded King has responded

  
teen4christ
Member (Idle past 4135 days)
Posts: 238
Joined: 01-15-2008


Message 66 of 569 (454089)
02-05-2008 2:26 PM
Reply to: Message 64 by Dr Adequate
02-05-2008 9:41 AM


Re: What Happens When A Ribosome Translates mRNA Lacking A Stop Codon?
I'd imagine it's like having a program with an infinite loop.

This message is a reply to:
 Message 64 by Dr Adequate, posted 02-05-2008 9:41 AM Dr Adequate has responded

Replies to this message:
 Message 68 by Dr Adequate, posted 02-07-2008 9:14 AM teen4christ has not yet responded

  
Dr Adequate
Member
Posts: 16107
Joined: 07-20-2006
Member Rating: 8.3


Message 67 of 569 (454469)
02-07-2008 9:11 AM
Reply to: Message 65 by Wounded King
02-05-2008 9:48 AM


Re: What's that you say Dr.A?
Thanks. That seems to conflict with the idea I'd picked up that frameshift mutations are less harmful near the end of the gene. 'Cos the nearer the end of the gene they are, the more likely it is that the frameshift will make the thing nonstop.

I am also now more curious than ever to know how amber suppressor strains get away with it.

Edited by Dr Adequate, : No reason given.


This message is a reply to:
 Message 65 by Wounded King, posted 02-05-2008 9:48 AM Wounded King has responded

Replies to this message:
 Message 69 by Wounded King, posted 02-07-2008 11:28 AM Dr Adequate has responded

  
Dr Adequate
Member
Posts: 16107
Joined: 07-20-2006
Member Rating: 8.3


Message 68 of 569 (454470)
02-07-2008 9:14 AM
Reply to: Message 66 by teen4christ
02-05-2008 2:26 PM


Re: What Happens When A Ribosome Translates mRNA Lacking A Stop Codon?
I'd imagine it's like having a program with an infinite loop.

No, not really. The bit of mRNA may not have a stop codon, but it still has an end. If there's no stop codon, the ribosome would keep on going down the mRNA stringing amino acids together until it reached the 3' end of the mRNA. What was puzzling me was what would happen then.


This message is a reply to:
 Message 66 by teen4christ, posted 02-05-2008 2:26 PM teen4christ has not yet responded

  
Wounded King
Member (Idle past 2431 days)
Posts: 4149
From: Edinburgh, Scotland
Joined: 04-09-2003


Message 69 of 569 (454502)
02-07-2008 11:28 AM
Reply to: Message 67 by Dr Adequate
02-07-2008 9:11 AM


Re: What's that you say Dr.A?
Thanks. That seems to conflict with the idea I'd picked up that frameshift mutations are less harmful near the end of the gene. 'Cos the nearer the end of the gene they are, the more likely it is that the frameshift will make the thing nonstop.

Well it wouldn't necessarily make it much more likely to have a 'nonstop' transcript in any case as there is still a high likelihood there will be a new stop site introduced by the frameshift either in the remaining coding sequence or in the 3' untranslated region.

TTFN,

WK


This message is a reply to:
 Message 67 by Dr Adequate, posted 02-07-2008 9:11 AM Dr Adequate has responded

Replies to this message:
 Message 70 by Dr Adequate, posted 02-07-2008 11:55 AM Wounded King has acknowledged this reply

  
Dr Adequate
Member
Posts: 16107
Joined: 07-20-2006
Member Rating: 8.3


Message 70 of 569 (454507)
02-07-2008 11:55 AM
Reply to: Message 69 by Wounded King
02-07-2008 11:28 AM


Re: What's that you say Dr.A?
True; but nonetheless the closer the frameshift is to the end, the less likely it is to produce another stop codon.

I just realised that I don't know how big the bit after the stop codon is, typically ... if it tends to be large and varied, I guess that nonstop mRNA wouldn't occur that often no matter where the frameshift takes place.


This message is a reply to:
 Message 69 by Wounded King, posted 02-07-2008 11:28 AM Wounded King has acknowledged this reply

  
BMG
Member (Idle past 2499 days)
Posts: 356
From: Southwestern U.S.
Joined: 03-16-2006


Message 71 of 569 (454732)
02-08-2008 1:32 PM


Global cooling
Please do not reply here. This has been reposted as a new thread: Global Cooling?. --Admin

Someone posted this article I have below as support that the global warming phenomenon is a "hoax", and that the Earth is likely going to cool.

http://ibdeditorial.com/IBDArticles.aspx?id=287279412587175

I have yet to refute this argument. I am researching now the sources that are used in the article, and the effects of the solar cycle on the Earth's climate, but I could use the help of the EVC team. Here are some quotes from the article itself:

"[Kenneth] Tapping reports no change in the sun's magnetic field so far this cycle and warns that if the sun remains quiet for another year or two, it may indicate a repeat of that period of drastic cooling of the Earth, bringing massive snowfall and severe weather to the Northern Hemisphere".

And one more, from the Hoover Institution, "The effects of solar activity and volcanoes are impossible to miss. Temperatures fluctuated exactly as expected, and the pattern was so clear that, statistically, the odds of the correlation existing by chance were one in 100," according to Hoover fellow Bruce Berkowitz. "

One more, from the Hoover Institution, "The study says that 'try as we might, we simply could not find any relationship between industrial activity, energy consumption and changes in global temperatures'".

Edited by Admin, : Add comment about new thread.


  
AZPaul3
Member
Posts: 4780
From: Phoenix
Joined: 11-06-2006
Member Rating: 4.9


Message 72 of 569 (455111)
02-10-2008 2:39 PM
Reply to: Message 1 by AdminPD
11-11-2007 9:53 AM


IIRC?
What does IIRC mean as used on this forum?

Thanks much in advance.


This message is a reply to:
 Message 1 by AdminPD, posted 11-11-2007 9:53 AM AdminPD has not yet responded

Replies to this message:
 Message 73 by Chiroptera, posted 02-10-2008 2:59 PM AZPaul3 has responded

  
Chiroptera
Member
Posts: 6831
From: Oklahoma
Joined: 09-28-2003
Member Rating: 6.6


Message 73 of 569 (455115)
02-10-2008 2:59 PM
Reply to: Message 72 by AZPaul3
02-10-2008 2:39 PM


Re: IIRC?
If I recall correctly.

This message is a reply to:
 Message 72 by AZPaul3, posted 02-10-2008 2:39 PM AZPaul3 has responded

Replies to this message:
 Message 74 by AZPaul3, posted 02-10-2008 3:19 PM Chiroptera has not yet responded

  
AZPaul3
Member
Posts: 4780
From: Phoenix
Joined: 11-06-2006
Member Rating: 4.9


Message 74 of 569 (455118)
02-10-2008 3:19 PM
Reply to: Message 73 by Chiroptera
02-10-2008 2:59 PM


Re: IIRC?
Thank you.

This message is a reply to:
 Message 73 by Chiroptera, posted 02-10-2008 2:59 PM Chiroptera has not yet responded

  
Taz
Member (Idle past 1628 days)
Posts: 5069
From: Zerus
Joined: 07-18-2006


Message 75 of 569 (455139)
02-10-2008 9:08 PM
Reply to: Message 62 by Cold Foreign Object
02-02-2008 3:03 PM


CFO writes:

Whatever happened to Crashfrog?


He is in his period of slumber.

Why is Jar banned?

He was struck down by god (aka Percy) along with a whole bunch of other people during the 2008 admin massacre.

Ray

Oddly enough, he's still in favor with god for some reason :p

This message is a reply to:
 Message 62 by Cold Foreign Object, posted 02-02-2008 3:03 PM Cold Foreign Object has not yet responded

  
Newer Topic | Older Topic
Jump to:


Copyright 2001-2018 by EvC Forum, All Rights Reserved

™ Version 4.0 Beta
Innovative software from Qwixotic © 2019