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Author Topic:   Guilty feelings.
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 6 of 46 (462509)
04-04-2008 12:21 PM
Reply to: Message 5 by Larni
04-04-2008 12:18 PM


Re: Guilt = understanding a missed oportunity to do better
I would say this is cognitive rather than psysical.
Cognitive is physical.

This message is a reply to:
 Message 5 by Larni, posted 04-04-2008 12:18 PM Larni has replied

Replies to this message:
 Message 8 by Larni, posted 04-04-2008 1:16 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 13 of 46 (462523)
04-04-2008 2:37 PM
Reply to: Message 8 by Larni
04-04-2008 1:16 PM


Re: Guilt = understanding a missed oportunity to do better
Explain how.
Seriously?
You doubt that your cognitive functions are the result of physical processes?

This message is a reply to:
 Message 8 by Larni, posted 04-04-2008 1:16 PM Larni has replied

Replies to this message:
 Message 14 by Larni, posted 04-04-2008 2:42 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 16 of 46 (462527)
04-04-2008 3:02 PM
Reply to: Message 14 by Larni
04-04-2008 2:42 PM


Re: Guilt = understanding a missed oportunity to do better
But if you mean physical in as much as anxiety is expressed in a physical reaction then I would again ask you to justify your response.
I can't believe you're even asking.
Several neurotransmitters are involved in the regulation of fears and anxieties. These include GABA, Dopamine, Serotonin, Acetylcholine and Norepinephrine3.
” GABA
Gamma Aminobutyric acid. Generally considered an inhibitory neurotransmitter that is widely distributed in the brain 6. GABA is produced from glutamate and its effects are not well characterized.
” Dopamine
Dopamine produces behavioral quieting and there are multiple receptors in the brain. Dopamine is thought to have a role in Cognitive Dysfunction 7 and in Cushings disease in dogs.
” Serotonin
Produced in the brain from tryptophan. Multiple receptor subtypes in the brain. Thought to play a role in sleep, pain aggression, sexual behavior, anxiety, thermoregulation, food intake and social attachment.
” Acetylcholine
Most widely distributed neurotransmitter in the brain and body. Produced from choline and inactivated by acetylcholinesterase. Responsible for numerous side effects with medications.
” Norepinephrine
Precursor of epinephrine and also can act centrally. In behaviorally stimulating and increases arousal via activation of the reticular activating system.
http://www.vin.com/...archPB/Proceedings/PR05000/PR00311.htm
There have been tremendous advances in our knowledge of the neurobiological basis of human anxiety and fear. This review seeks to highlight how specific neuronal circuits, neural mechanisms, and neuromodulators play a critical role in anxiety and fear states. It focuses on several brain structures, including the amygdala, locus coeruleus, hippocampus, and various cortical regions and the functional interactions among brain noradrenergic (NE), corticotropin releasing hormone (CRH), and the hypothalamic pituitary adrenal axis (HPA). Particular attention is directed toward results that can lead to a better understanding of the constellation of the symptoms associated with two of the more severe anxiety disorders, panic disorder and posttraumatic stress disorder (PTSD), the persistence of traumatic memories, and the effects of stress, particularly early life adverse experiences, on brain function and clinical outcome.
Review : The Neurobiological Basis of Anxiety and Fear: Circuits, Mechanisms, and Neurochemical Interactions
The Neuroscientist, Vol. 4, No. 1, 35-44 (1998)
What else could anxiety (or any emotion, for that matter) possibly be?

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 Message 14 by Larni, posted 04-04-2008 2:42 PM Larni has replied

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 Message 17 by Larni, posted 04-04-2008 3:14 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 18 of 46 (462531)
04-04-2008 3:40 PM
Reply to: Message 17 by Larni
04-04-2008 3:14 PM


Re: Guilt = understanding a missed oportunity to do better
The insula has been implicated in the generation of affective states in response to emotive stimuli. Studies have also highlighted the role of the insula during recall of internally generated emotion [Reiman et al 1997] and during the experience of guilt [Shin et al 2000], a complex emotion that, like the experience of shame, may involve self-directed disgust. There is therefore accumulating evidence for the role of the insula in mediating behavior to aversive, including disgust-related, stimuli.
The ventrolateral prefrontal cortex can be defined as lateral and rostral regions of Brodmann area 47 and part of Brodmann area 45 and lies lateral to the orbitofrontal cortex on the ventral surface of the frontal lobes [Ongur and Price 2000]. Human functional neuroimaging studies have demonstrated increased blood flow and activation within this region during a variety of tasks, including the induction of sad mood [Pardo et al 1993] and guilt [Shin et al 2000], during the recall of personal memories [Fink et al 1996] and emotional material [Reiman et al 1997], and in response to facial expressions displaying different negative emotions [Sprengelmeyer et al 1996], particularly when specific tasks are performed in response to the expressions [Lange et al 2003]. The right temporofrontal junction and related right-sided ventrolateral prefrontal cortex have also been associated with autobiographical memory retrieval [Markowitsch 1997].
Mary L. Phillipsa, Wayne C. Drevetsb, Scott L. Rauchc and Richard Laned, Neurobiology of emotion perception I: the neural basis of normal emotion perceptionnext term, Biological Psychiatry, Volume 54, Issue 5, 1 September 2003, Pages 504-514
Shin et al 2000. Activation of anterior paralimbic structures during guilt-related script-driven imagery. Biol Psychiatry 48 (2000), pp. 43-50.
Recent neuroimaging studies have reported the neural substrate of moral judgment (Greene et al., 2001, Moll et al., 2002a and Moll et al., 2002b). However, few reports are available on specific moral or social emotions (Berthoz et al., 2002 and Shin et al., 2000).
Impairment of possessing the mental states of these moral emotions could lead to amoral, inappropriate behaviors observed in neurological and psychiatric disorders such as brain injuries (Anderson et al., 1999 and Beer et al., 2003), frontotemporal dementia (Miller et al., 2003 and Snowden et al., 2002), autism (Capps et al., 1992, Frith, 2001 and Hillier and Allinson, 2002), and antisocial personality (Brower and Price, 2001 and Moll et al., 2003). Studying the neural substrates of judgments of moral emotions should add to the understanding of the neural basis of amoral behaviors observed in neurological and psychiatric disorders.
A previous positron emission tomography (PET) study using a guilt-related script reported a slightly different activation pattern in anterior paralimbic regions during the experience of guilt (Shin et al., 2000).
Both guilt and embarrassment conditions commonly activated the medial prefrontal cortex (MPFC), left posterior superior temporal sulcus (STS), and visual cortex. Compared to guilt condition, embarrassment condition produced greater activation in the right temporal cortex (anterior), bilateral hippocampus, and visual cortex. Most of these regions have been implicated in the neural substrate of social cognition or Theory of Mind (ToM). Our results support the idea that both are self-conscious emotions, which are social emotions requiring the ability to represent the mental states of others. At the same time, our functional fMRI data are in favor of the notion that evaluative process of embarrassment might be a more complex process than that of guilt.
Hidehiko Takahashia, Noriaki Yahatac, Michihiko Koedad, Tetsuya Matsudae, Kunihiko Asaib and Yoshiro Okubo, Brain activation associated with evaluative processes of guilt and embarrassment: an fMRI study, NeuroImage, Volume 23, Issue 3, November 2004, Pages 967-974
Edited by molbiogirl, : another paper

This message is a reply to:
 Message 17 by Larni, posted 04-04-2008 3:14 PM Larni has replied

Replies to this message:
 Message 19 by Larni, posted 04-04-2008 4:35 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 20 of 46 (462539)
04-04-2008 7:39 PM
Reply to: Message 19 by Larni
04-04-2008 4:35 PM


Re: Guilt = understanding a missed oportunity to do better
My point about the physical reaction vs a cognitive reation is that (given that all cognition requires the brain- a physical entity) cognition is a mental process (occuring of course in the brain - a physical structure) where as anxiety is a psysical process (hormonal in this case).
Larni, the structures of the brain don't just light up "all by themselves".
Neurochemistry is responsible for all emotions, including guilt.
And were I willing to dedicate another 1/2 hour to poking around scholar.google, I could tell you exactly which hormones are responsible for guilt.

This message is a reply to:
 Message 19 by Larni, posted 04-04-2008 4:35 PM Larni has replied

Replies to this message:
 Message 21 by Larni, posted 04-04-2008 7:56 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 22 of 46 (462548)
04-04-2008 9:21 PM
Reply to: Message 21 by Larni
04-04-2008 7:56 PM


Re: Guilt = understanding a missed oportunity to do better
No offense taken, Larni.
I'm still confused, tho.
You said "whereas" anxiet/guilt is hormonal. Cognition is too.
Neurotransmitters are hormone/peptide/amino acid/monoamine:
wiki writes:
* Around 10 "small-molecule neurotransmitters" are known:
o acetylcholine (Ach)
o monoamines (epinephrine (E), norepinephrine (NE), dopamine (DA), serotonin (5-HT) and melatonin)
o 3 or 4 amino acids, depending on exact definition used: (primarily glutamic acid, gamma aminobutyric acid (GABA), aspartic acid & glycine)
o Purines, (Adenosine, ATP, GTP and their derivatives)
o Fatty acids are also receiving attention as the potential endogenous cannabinoid.[citation needed]
* Over 50 neuroactive peptides (vasopressin, somatostatin, neurotensin, etc.) have been found, among them hormones such as Luteinizing hormone (LH) or insulin that have specific local actions in addition to their long-range signalling properties.
* Histamine
* Single ions, such as synaptically-released zinc, are also considered neurotransmitters by some.[citation needed]
* Gaseous, including: Nitrogen monoxide (NO) and Carbon monoxide (CO)
I guess I still don't know what distinction you are drawing.
The only difference between guilt and cognition is the chemical used to signal the appropriate part of the brain.
Edited by molbiogirl, : No reason given.
Edited by molbiogirl, : sp

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molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 23 of 46 (462552)
04-04-2008 9:57 PM
Reply to: Message 21 by Larni
04-04-2008 7:56 PM


Re: Guilt = understanding a missed oportunity to do better
Do you mean something like this?
Nervousness, blinking eyes, sweating, heavier breathing, higher heart rate, shaking, voice breaks when talking, cannot sit still, hands tremble, lips quiver
Feeling nauseous, tired and unable to get on with the day.
Sweating, heavier breathing, perhaps blushing.
These are self reported "guilt symptoms" from here:
http://answers.yahoo.com/question/index?qid=2007112513484...

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 Message 21 by Larni, posted 04-04-2008 7:56 PM Larni has replied

Replies to this message:
 Message 24 by Larni, posted 04-05-2008 5:52 AM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 25 of 46 (462587)
04-05-2008 12:30 PM
Reply to: Message 24 by Larni
04-05-2008 5:52 AM


Re: Guilt = understanding a missed oportunity to do better
I get queasy, yes. But that's not important. One person's experience is right next to useless.
There are a bunch of papers in the literature that report similar findings, however.
Guilt is very much like anxiety/embarrassment/shame. All share "physical" symptoms.
ABE:
Just to clarify, the physical "symptoms" of guilt are reported in the literature. As are those for anxiety/embarrassment/shame. There doesn't seem to be any question that guilt manifests itself "physically".
This can lead to feelings of guilt and shame. The psychological distress engendered by these feelings may be expiated through physical pain or suffering [64, 65]. The location of the pain in the abdomen, pelvis, or genitourinary area is logical to the psyche because this area represents the "bad" or offending part of the body that is to be punished.
Index of /
... weakness in the right arm and leg, spasmodic eye blinking, facial tics, and a constant state of drowsiness ...
A dysfunction at the level of the serotonergic and noradrenergic neurons can thus affect both the ascending and descending pathways resulting in the psychological and somatic symptoms of depression but also in physical painful symptoms.
Feelings of guilt may be related to projections to the limbic area. Psychomotor retardation or agitation may be linked to problems in the various motor projections, while vegetative symptoms such as changes in appetite or weight, lack of pleasure and sleep abnormalities may relate to dysfunction of innervation of the hypothalamus and the sleep centres.
http://www3.interscience.wiley.com/...act/109629662/ABSTRACT
This paper specifically mentions serotonergic and noradrenergic pathways as those responsible.
The Maier subscale isolates core emotional symptoms of depression (depressed mood, guilt, retardation, agitation, anxiety), while the HAMD17 total score assesses both psychological and physical symptoms.
Onset of action for duloxetine 60 mg once daily: double-blind, placebo-controlled studies, Journal of Psychiatric Research, Volume 39, Issue 2, March 2005, Pages 161-172
The classic symptoms of depression found in the DSM-IV criteria--such as depressed mood, feelings of worthlessness or guilt, inability to concentrate, anxiety or irritability--are generally familiar to practitioners. Perhaps less familiar are the physical symptoms, which can include aches and pains (especially musculoskeletal pain), headache, gastrointestinal disturbance, chest tightness, fatigue, weakness and alterations in appetite and weight.
It is now known that, in addition to sending projections throughout the brain, serotonin and norepinephrine cell bodies also send neuronal projections down the spinal cord. These neurons act as regulators, balancing the need to respond to sensations from inside and outside the body. Descending pathways normally suppress routine sensory input, but malfunctions can lead to sensations escaping up the spinal cord to the brain, where they are misinterpreted as pain. Because serotonin and norepinephrine modify the effects of pain mediators such as gamma-aminobutyric acid (GABA) and substance P, decreased levels of either of these monoamine neurotransmitters may cause increased sensitivity to pain.
Role of Physical Symptoms in Diagnosis of Depression in the Elderly, Geriatrics and Aging, Volume 5, Number 8, October 2002, Pages 18-21.
Edited by molbiogirl, : No reason given.

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 Message 24 by Larni, posted 04-05-2008 5:52 AM Larni has replied

Replies to this message:
 Message 26 by Larni, posted 04-06-2008 8:21 AM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 27 of 46 (462644)
04-06-2008 2:16 PM
Reply to: Message 26 by Larni
04-06-2008 8:21 AM


Re: Guilt = understanding a missed oportunity to do better
I could find nothing in this refering to guilt having physiological symptoms. Did you even read it?
It's in the quote, Larni.
This can lead to feelings of guilt and shame. The psychological distress engendered by these feelings may be expiated through physical pain or suffering [64, 65]. The location of the pain in the abdomen, pelvis, or genitourinary area is logical to the psyche because this area represents the "bad" or offending part of the body that is to be punished.
Larni writes:
Anxiety and shame are not guilt.
I didn't say they were. I said the symptoms for all 4 (anxiety/shame/embarrassment/guilt) are alike.
So far you have shown only the psysiological symptoms anxiety.
No. The above quote show that guilt and shame have physiological symptoms.
Granted guilt is not distinguished from shame.
GUILT IS NOT DEPRESSION!
I didn't say that is was. Guilt is a part of depression.
In my previous post, guilt is not separated from the rest of the feelings associated with depression, but I thought it important to include that study as it pinpoints the neurotransmitters that produce the pain.
Guilt isn't often studied by neurobiologists. As Hidehiko noted in the quote I posted earlier:
However, few reports are available on specific moral or social emotions (Berthoz et al., 2002 and Shin et al., 2000).
Larni writes:
Feelings of guilt may be related to projections to the limbic area.
Yes. Again I say: I KNOW THIS.
I didn't write that. Stahl et al did.
And you ignored the rest of the quote.
Psychomotor retardation or agitation may be linked to problems in the various motor projections, while vegetative symptoms such as changes in appetite or weight, lack of pleasure and sleep abnormalities may relate to dysfunction of innervation of the hypothalamus and the sleep centres.
Larni writes:
Symptoms of depression were expected to correlate positively with shame, but not with guilt.
Good find!
But, unfortunately, those findings are not consistent with others in the literature.
In summary, Wright et al. are to be applauded for their empirical approach to understanding the roles of shame, guilt, and sex differences in depression and narcissism. However, the lack of construct validity for the ASGS guilt scale raises serious doubts regarding some of their conclusions. In contrast to those conclusions, other studies indicate that guilt may not be any less involved in the formation of depression than shame, and that guilt as well as shame may be more common in women than men.
Wright, F., O'Leary, J., Balkin, J., Shame, Guilt, Narcissism, and Depression: Correlates and Sex Differences, Psychoanal. Psychol., 6:217-230.
In conclusion, we have shown profound dysregulation of IL-6 secretion in patients with diagnosis of Major Depressive Disorder ... Correlations between daily mean log-transformed plasma IL-6 levels and VAS scores for concentration (A), guilt (B), sadness (C), self-esteem (D), suicidal thoughts (E), and tiredness (F) in five MDD patients and matched controls. Correlations of IL-6 with guilt, self-esteem, and suicidal thoughts remained significant after Bonferroni correction.
Alesci, Salvatore, Major Depression Is Associated with Significant Diurnal Elevations in Plasma Interleukin-6 Levels, a Shift of Its Circadian Rhythm, and Loss of Physiological Complexity in Its Secretion: Clinical Implications. Journal of Clinical Endocrinology & Metabolism. 90(5):2522-2530, May 2005.
Please note that guilt was measured separately from the other emotions.
The symptom “feelings of guilt” is a central feature of major depression ... Recent advances in the psychometric measurement of guilt have led to the development of several new validated measures of guilt. In the current study, we have applied these new measures to address the following unanswered questions: (1) Do subjects with depression experience any more guilt than matched comparison subjects with a chronic medical illness or healthy controls? (2) What is the relationship between the severity of depression and the degree of guilt expressed? (3) Is depression associated with state-guilt, trait-guilt or both? ... The current data support the notion that feelings of guilt are both an enduring and fluctuating feature of major depression.
Kayhan Ghatavi et al, Defining guilt in depression:next term a comparison of subjects with major depression, chronic medical illness and healthy controls, Journal of Affective Disorders, Volume 68, Issues 2-3, April 2002, Pages 307-315.
Now. About the physiological symptoms of guilt.
The largest amount of physiological symptoms is reported for fear and the smallest amount for guilt and disgust.
Facets of Emotion, Klaus R. Scherer.
Please note that although the physiological symptoms of guilt are less prominent than those of fear, they do exist!

This message is a reply to:
 Message 26 by Larni, posted 04-06-2008 8:21 AM Larni has replied

Replies to this message:
 Message 29 by Larni, posted 04-06-2008 3:33 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 32 of 46 (462658)
04-06-2008 5:06 PM
Reply to: Message 29 by Larni
04-06-2008 3:33 PM


Re: Guilt = understanding a missed oportunity to do better
The function of a neurotransmitter is not a symptom.
The pain is the symptom. The neurotransmitter is the trigger.
To repeat: "It is now known that, in addition to sending projections throughout the brain, serotonin and norepinephrine cell bodies also send neuronal projections down the spinal cord."
The pain is generated by the neurotransmitters in the spinal cord.
Why do you keep harping on about depression?
Because the paper I mentioned specifically measured the "guilt component" of depression and showed it resulted in physiological symptoms.
You have still not presented them.
Should you wish to look at the study in the book I cited earlier, books.google the title: Facets of Emotion. On page 45, you will find a table with the results. The symptoms include: lump in throat, breathing, stomach, feeling cold, feeling warm, feeling hot, heartbeat, muscles tense, muscle relaxed, perspiring and other symptom.
I can't copy and paste the table as books.google won't let me.
I honestly have no idea why you are so resistant to the idea that guilt has physiological symptoms.

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molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 33 of 46 (462670)
04-06-2008 7:23 PM
Reply to: Message 29 by Larni
04-06-2008 3:33 PM


Re: Guilt = understanding a missed oportunity to do better
Jackpot.
Survivor guilt (aka survivor syndrome).
Scholar.google that puppy!
Physiological symptoms out the wazoo.

This message is a reply to:
 Message 29 by Larni, posted 04-06-2008 3:33 PM Larni has replied

Replies to this message:
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molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 39 of 46 (462715)
04-07-2008 6:31 PM
Reply to: Message 38 by Larni
04-07-2008 4:44 PM


Re: Software vs hardware
Yah. This is the same issue I'm having with molbiogirl. I absolutely agree that you are correct.
Larni, you've lost me again.
However, the hardware of the brain runs the software i.e. the meaning ascribed to the thought. No hardware, no thought.
By way of analogy, here's what this sounds like to me:
"The hardware of the genome runs the software i.e. the information generated by the base sequence."
In other words, it makes no sense whatsoever to separate the information encoded by the genome from the genome. Nor does it make any sense to separate the information generated by the brain from the brain.
Edited by molbiogirl, : No reason given.

This message is a reply to:
 Message 38 by Larni, posted 04-07-2008 4:44 PM Larni has replied

Replies to this message:
 Message 42 by Larni, posted 04-08-2008 7:21 AM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 43 of 46 (462735)
04-08-2008 10:14 AM
Reply to: Message 42 by Larni
04-08-2008 7:21 AM


Re: Software vs hardware
And I'm still waiting for you to look up the cite I've already provided.

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molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 44 of 46 (462739)
04-08-2008 11:40 AM
Reply to: Message 42 by Larni
04-08-2008 7:21 AM


Re: Software vs hardware
btw.
A person who is anxious may describe only psychological symptoms (inner feelings of tension, agitation, out-of-control) or physical symptoms (palpitations, difficulty breathing, tightness in the chest, butterflies, sweating, an urge to go to the bathroom).
Similarly, a person who is guilty may describe either psychological or physical symptoms.
My guess is, were you to ask one of your patients who is plagued by guilt, "Do you have any physical symptoms?", the answer would be yes.

This message is a reply to:
 Message 42 by Larni, posted 04-08-2008 7:21 AM Larni has replied

Replies to this message:
 Message 45 by Larni, posted 04-08-2008 12:10 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 46 of 46 (462743)
04-08-2008 12:15 PM
Reply to: Message 45 by Larni
04-08-2008 12:10 PM


Re: Software vs hardware
I still hold that it is very usefull to conceptualize cognitions and percieved psyiological symptoms as different.
You'll get no argument from me there.

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