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Author Topic:   More on the function of "junk" DNA
Dr Jack
Member (Idle past 447 days)
Posts: 3507
From: Leicester, England
Joined: 07-14-2003


Message 1 of 3 (471132)
06-14-2008 5:58 PM


Not exactly a news post, but a blog on some recent research. I hope it qualifies.

Link

Essentially what they've done is search for the sections of human DNA which show greater-than-normal differences from chimp DNA, that is, compared to that expected by random mutation and thus taken to be most likely to have undergone selection.

47 of the 49 DNA segments they've identified occur in non-coding sections of DNA (junk DNA, as it is sometimes called). In particular, they identified a section HAR1 which occurs near sections coding for brain development, that has changed at 18 times base rate. The team are not sure what this section does but believe the RNA it produces is involved in switching other genes on and off.

Interesting stuff.


Replies to this message:
 Message 2 by Wounded King, posted 06-15-2008 6:29 PM Dr Jack has not yet responded
 Message 3 by Brad McFall, posted 06-15-2008 9:29 PM Dr Jack has not yet responded

  
Wounded King
Member (Idle past 2437 days)
Posts: 4149
From: Edinburgh, Scotland
Joined: 04-09-2003


Message 2 of 3 (471250)
06-15-2008 6:29 PM
Reply to: Message 1 by Dr Jack
06-14-2008 5:58 PM


HAR1 has been brought up previously in the thread on human brain evolution, Genetics and Human Brain Evolution.

TTFN,

WK


This message is a reply to:
 Message 1 by Dr Jack, posted 06-14-2008 5:58 PM Dr Jack has not yet responded

  
Brad McFall
Member (Idle past 3375 days)
Posts: 3428
From: Ithaca,NY, USA
Joined: 12-20-2001


Message 3 of 3 (471292)
06-15-2008 9:29 PM
Reply to: Message 1 by Dr Jack
06-14-2008 5:58 PM


A function for JunkDNA in macrothermodynamics
By rejecting Fisher's perspective I have been able to construct a heritable version of Dr. Gladyshev's principle of substance stability. The temporally longer life"" times of control regions over what they regulate led me to suggest that repetative DNA actually creates the control regions themselves.
http://aexion.org/monohierarchy.aspx
I have linked to some work which suggests a relation of transposon targeting NOT to structural genes.

If my theoretical explanation of Dr. Gladyshev's work is correct there may be a new thermodynamic way to think about "junkDNA".

The thought suggests answers to YEC concerns for the lack of an energy converter in Neo-Darwinism and Johnson's concern about the "origin" of genetic information.

Dr. Gladyshev is currently recuperating from heart problems outside Moscow .

I will obviously be focusing now on the kinds of transposons and why they target regualatory areas.

The idea that led to this was the notion that new mutant alleomorph create a different entropic population enviroment. The fact tht atoms have zero free energy by definition is the reason, if true, this insight has been missed so far.

Edited by Brad McFall, : "of"


This message is a reply to:
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