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Genetic load: can someone explain?

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Author Topic:   Genetic load: can someone explain?
BVZ
Member (Idle past 5512 days)
Posts: 36
Joined: 08-20-2008

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Message 1 of 53 (488765)
11-17-2008 5:39 AM

A Creationist has pointed me to this article:
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Estimate of the Mutation Rate per Nucleotide in Humans | Genetics | Oxford Academic
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It seems pretty interesting, but most of it goes over my head.
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I would like to know how the theory of evolution addresses the problem. To be more specific, this part:
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The high deleterious mutation rate in humans presents a paradox. If mutations interact multiplicatively, the genetic load associated with such a high U would be intolerable in species with a low rate of reproduction (MULLER 1950 ; WALLACE 1981 ; CROW 1993 ; KONDRASHOV 1995 ; EYRE-WALKER and KEIGHTLEY 1999 ). The reduction in fitness (i.e., the genetic load) due to deleterious mutations with multiplicative effects is given by 1 - e-U (KIMURA and MORUYAMA 1966 ). For U = 3, the average fitness is reduced to 0.05, or put differently, each female would need to produce 40 offspring for 2 to survive and maintain the population at constant size.
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Thank you.
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 Message 3 by Wounded King, posted 11-17-2008 9:33 AM BVZ has replied
  
BVZ
Member (Idle past 5512 days)
Posts: 36
Joined: 08-20-2008

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Message 13 of 53 (488818)
11-18-2008 12:23 AM 		Reply to: Message 3 by Wounded King
11-17-2008 9:33 AM

Re: It's all in the synergy
Hey, thank you for the reply.
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Were you not interested in how Nachman and Crowell addressed the problem themselves?
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I was. That is partly why I posted here. I don't know enough to find where research is being done on this particular problem. The solutions given in the article are ad-hoc. This is not a problem, since any hypothesis proposed to solve a newly discovered problem will be ad-hoc. As long as evidence can be found to support the hypothesis, I don't see a problem.
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The two links you provided are a good start. Are there any other links and info I can read up on?
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