"Macro" vs "Micro" genetic "kind" mechanism?

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One of the most important things to point out here, IMO, is the typical reproductive overcapacity of organisms: even in the absence of any deadly mutations and other causes of death, the available resources and environment would eventually limit how many organisms would stay alive. Darwin himself calculated how many elephants (very slow breading animals!) there would be if so many wouldn't die because of survival of the fittest: in a geological blink of an eye the whole solarsystem would be filled with elephant poop (that's not exactly his calculation, but it amounts to the same !This insight was extremely important for Darwin to come up with his concept of natural selection, and he got it mainly by reading the work of Thomas Malthus, "An Essay on the Principle of Population"The reproductive overcapacity means that the impact of detrimental, deadly mutations is nearly meaningless. It's not much more than background noise.