While saltation caused by the mutation of HOX genes or other controlling genes is plausible, at this point it is only hypothetical.
[quibble] while not necessarily due to "HOX genes or other controlling genes" there are many examples of saltationist speciation through
polyploidy, most common in plants, but not unknown in animals. Polyploidy involves the sudden duplication of chromosomes that make interbreeding between parent and daughter population impossible, thus speciation has occurred.[/quibble]
This has been observed in the field under controlled conditions, and in the lab.
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