Firstly any hypothesis that has not been confirmed (for whatever reason) must be regarded as speculative. But there is a spectrum here. Even an easily confirmed hypothesis must precede confirmation, and I do not think that the time between the proposal and the confirmation can itself be considered a qualitative difference. Thus we have something of a spectrum:
A hypothesis that can be confirmed immediately
A hypothesis that can be confirmed when the (existing) resources are available
A hypothesis that cannot be confirmed with current technology, but can be expected to be investigable in the near future.
and so on.
A hypothesis that cannot, in principle, be confirmed is arguably outside that spectrum since there is no prospect of ever being able to investigate it.
The other, related point is what are the grounds for believing the hypothesis to be true ? If the hypothesis is derived from a theory with strong confirmation, for instance, we should have far more confidence in it than if the ground were themselves speculative.
The existence of extraterrestrial life, for instance, can be supported by quite strong arguments (which have nothing to do with UFOlogy). The existence of an "Intelligent Designer" on the other hand is supported only by weak arguments. And that is the primary difference between them (that the Intelligent Designer is put beyond investigation has more to do with the weakness of the arguments for it than anything inherent in the loose concept).