A paper is due to be published shortly in the journal Current Biology which compares the Y-chromosomes of two men from the same family but several generations apart (
Xue et al., 2009).
They arrive at results showing similar levels of mutation to those discussed previously. They identify 4 new mutations to have arisen
in vivo in the intervening 13 generations and from that derive a mutation rate of 3x10
-8 mutations/nucleotide/generation. This gives roughly ~150 new single nucleotide mutations/ diploid genome/ generation, more than Kondrashov's estimate but within a very similar ball park.
TTFN,
WK