Most people find uncertainty distressful. Some people find it very much so and tie themselves up in all kinds of cognitive knots to remove the uncertainity from their lives.
Some people have a very rigid way of life to try to eliminate as much uncertainty possible.
Some people need to believe that [i]this[i] is the correct answer and that is that and anything that conflicts with that is very very bad as it causes distress.
This is what happens to people who put their faith in the inerrancy of what ever version of the bible they hold as gospel (pardon the pun).
Faith in science as the best way to examine the world means there will always be doubt in ones mind.
Some people can cope with this; some can't.