I made up a whole pantheon for my D&D game back in the day; they all had spheres of interest and enemies and allies. They where a really interesting bunch: but then interest waned and they fell out of favour.
We stopped paying so much interest (needs of the campaign and all that) to the panteon and their influence dimmed.
It got to a point where one of my players said "we don't bother with gods these days, do we?".
"It's too much bother for me to keep up with" I replied.
We never really bothered with them again.
Edited by Larni, : Clarity