Creationist will often complain when evolutionist use examples of micro-evolution to prove that macro-evolution will happen, because it simply does not discard the possibility that accumulating mutations could lead to genetic meltdown.
That is bullshit, because anything that might hinder the fitness of the species gets "filtered" out by natural selection.
Well in almost any species that is there is one exception human ever since our advances in medicine we kinda went around natural selection. If you have bad gens that might lead to Diabetis you do not die young you get insulin and they tell you what you can eat, and if you get bad geens for something else you can get treated for it so we are able to pass on the bad mutations more easely than any other animal.