Creationist will often complain when evolutionist use examples of micro-evolution to prove that macro-evolution will happen, because it simply does not discard the possibility that accumulating mutations could lead to genetic meltdown.
Creationists seem to have focused on "genetic meltdown" and "genetic entropy" lately.
Is there any evidence that these actually occur in normal populations?
I know that Sanford believes in this, but then he believes in a young earth. The fact that the earth is old completely changes the dynamics of his argument, and not for the better.
None of the other explanations creationists have put forth over the years have withstood the tests of science, and I suspect this one is no different.
Given that, there seems to be no barrier to a lot of micro-evolutionary events adding up over time to a macro.
Religious belief does not constitute scientific evidence, nor does it convey scientific knowledge.