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Author Topic:   Good Calories, Bad Calories, by Gary Taubes
molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 397 of 451 (631670)
09-02-2011 10:32 AM
Reply to: Message 394 by Percy
08-31-2011 8:15 AM


Re: Refined v. unrefined insulin response
Regarding #2 concerning the association of increased refined carbohydrate intake with obesity and type II diabetes, here is a study showing this effect with type II diabetes.
Percy, I took a look at that paper. That is one sad little excuse for a paper. Intheir discussion, they fall all over themselves to excuse their crappy analysis.
The results of this ecologic study need to be interpreted in the context of the study’s strengths and weaknesses. Ecologic studies, such as observational studies of individual persons, are susceptible to confounding.
Although food disappearance data are an indirect measure of individual consumption, these data have been calculated annually for more than a century, making them the only consistent data available for identifying secular trends (22).
Changes in diagnostic criteria and screening practices for type 2 diabetes may limit the ability to determine the extent of effect due solely to dietary changes.
The issue of confounding with obesity, physical activity, or both is challenging. Unfortunately, there is no uniform source of consistent information about physical activity in the United States for the period studied.
Use of such scant data to control for obesity would lack sufficient power to be meaningful.
And when the authors get around to discussing type of carb and its relation to insulin response, they cite papers that don't support their argument!
In several small-scale metabolic trials, refined grains have been shown to cause a significant increase in insulin secretion and the postprandial glucose response (50-54).
From 50:
Correlation with the in vivo data was imperfect. Oat-based meals evoked smaller glucose and insulin responses than wheat- or maize-based meals.
Particle size influences the digestion rate and consequent metabolic effects of wheat and maize but not oats.
Not real convincing, Percy.
51 didn't address insulin levels.
52 is the Hoyt paper.
53 deals with fat intake, not carb intake.
54 deals with overeating, not type of carb intake.
I think you need to find something that supports your argument. This undermines it.

This message is a reply to:
 Message 394 by Percy, posted 08-31-2011 8:15 AM Percy has seen this message but not replied

molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 417 of 451 (632524)
09-08-2011 12:05 PM
Reply to: Message 398 by Percy
09-02-2011 9:05 PM


Re: Refined v. unrefined insulin response
Well, I'm glad you've finally chosen to include the error bars!
Look at popcorn, tho. 54 +/- 9 is not 53. It is 45-63. Grapes are 82 +/- 6. That's 76-88.
(I made a mistake in my initial post, too. I said the error bars for popcorn were +/- 14. That's for the next food on the list, potato chips.)
Percy, take a look at your message #390. Popcorn was on your low IS list and grapes were on your high IS list. Popcorn is no where near the bottom and grapes are no where near the top.
When error bars overlap (or are very close), the difference between the two means is not statistically significant. (Google that if you don’t believe me.) Please note that there is significant overlap in much of the list. And grapes and popcorn are very close together.
Oranges, apples, popcorn and bread have an IS of 62-3. Are you arguing that a fructose laden orange/apple, a complex carb like popcorn, and a simple carb like bread are somehow different when they elicit an identical insulin response?
Look at what Holt calls similar.
(W)hole-meal bread and white bread had similar scores. White and brown rice had similar GSs and ISs, as did white and brown pasta.
Whole meal bread = 96 12 (108)
White bread = 100 0 (100)
White rice = 79 12 (91)
Brown rice = 62 11 (73)
White pasta = 40 5 (45)
Brown pasta = 40 5 (45)
The difference between breads is 108 - 100 = 8.
The difference between rices is 91 - 73 = 22.
Please note that these comparisons are between white and brown (refined and unrefined), too.
Grapes and popcorn are a lot closer than you seem to think.
And don't start in with the fiber thing.
According to Holt:
The ... fiber contents of the foods were not significantly related to the mean ISs.
Mean GSs were not significantly related to the foods' ... fiber contents.
Neither the glucose nor the insulin scores were related to fiber.
According to Jenkins:
There was, however, no relationship between glycemic index and dietary fiber or sugar content.
Surprisingly, no significant relationship was seen between glycemic index and dietary fiber.
Indeed, there was little difference between the high fiber wholemeal bread, spaghetti and brown rice and their low fiber white counterparts.
Jenkins, D et al. Glycemic index of foods: a physiological basis for carbohydrate exchange, American Journal of Clinical Nutrition, Vol 34, 362-366.
Or these papers.
Ullrich IH, Albrink MJ. Lack of effect of dietary fiber on serum lipids, glucose, and insulin in healthy young men fed high starch diets. Am J Clin Nutr l982;36: 1-9.
Manhire A, et al. Unrefined carbohydrate and dietary fibre in treatment of diabetes mellitus. J Hum Nutr 198 l;35:99-lOl.
Lindsay ANA et al. High carbohydrate, high-fiber diet in children with type 1 diabetes mellitus. Diabetes Care 1984;7:63-7.
Look. You can go on and on about how fructose is different from glucose is different from protein is different from carbs, but the insulin score is the insulin score.
It doesn’t matter if the insulin is in response to protein or carb, fructose or glucose. Blood samples were taken 8 times over a 2 hour period. If the IS is similar then it's similar. Period. And unrefined or complex carbs have similar/identical ISes as refined or simple carbs.
Furthermore, carbs have similar/identical ISes as proteins. That's a big problem for Taubes.
On to GI & II.
Englyst abstract as quoted by Percy writes:
In conclusion, the GI and II values of the cereal products investigated can be explained by the RAG and SAG contents. A high SAG content identifies low-GI foods that are rich in slowly released carbohydrates for which health benefits have been proposed.
Percy writes:
GI is Glycemic Index and II is Insulinemic Index. The conclusion is stating that SAG (Slowly Available Glucose) is associated with lower a glycemic index, and RAG (Rapidly Available Glucose) is associated with a higher glycemic index.
You really ought to read something other than the abstract, Percy.
Yes. GI correlates to II. And it's a very weak correlation.
The present study confirms the relationship between GI and II values for starchy foods, although the correlation is not
as strong
as reported previously (Bjorck et al. 2000).
It is possible that this rather weak association, and the observation that II values were higher than GI values, could be explained by the combined insulinotropic effects of protein, fat and possibly of other undetermined properties of the foods.
Note the wording! And this wording:
Holt et al. (1997) could only explain 23 % of the variance in the insulinscore by the glycaemic score of the foods.
RAG demonstrated the strongest correlation with II, but still only explained 32 % of the variance.
Let's take another look at the Holt paper:
There were large differences in mean glycemic and insulin responses to the foods, both within and between food groups.
A difference between the GI & the IS. A large difference.
Our study was undertaken to test the hypothesis that the postprandial insulin response was not necessarily proportional to the blood glucose response and that nutrients other than carbohydrate influence the overall level of insulinemia.
Their hypothesis was that the GI & the IS are not proportional.
As hypothesized, several foods with similar GSs had disparate ISs (eg, ice cream and yogurt, brown rice and baked beans, cake and apples, and doughnuts and brown pasta).
And that's what Holt found. The GS & the IS were different.
Therefore, the glycemic response was a significant predictor of the insulin response, but it accounted for only 23% of the variability in insulinemia.
The GI is a predictor of IS, and maybe a pretty good one, but it's a 1 out of 5 shot.
Thus, we can explain only 33% of the variation of the insulin responses to the 38 foods under examination.
And carbs are not a good predictor of IS.
Furthermore, equal-carbohydrate servings of foods do not necessarily stimulate insulin secretion to the same extent. For example, isoenergetic servings of pasta and potatoes both contained (about) 50g carbohydrate, yet the IS for potatoes was three times greater than that for pasta. Similarly, porridge and yogurt, and whole-grain bread and baked beans, produced disparate ISs despite their similar carbohydrate contents.
These findings, like others, challenge the (assumption) that portions of different foods containing 10-15g carbohydrate will have equal physiologic effects andwill require equal amounts of exogenous insulin to be metabolized.
Carbs can't predict insulin response.
Let's look at another paper. The Bao paper.
Surprisingly, in the current context, carbohydrate, fiber, and protein content were found to be relatively poor predictors of the overall insulin response.
Observed insulin responses varied over a 3-fold range (from 35 5 to 116 26). The carbohydrate content of the meals did not predict insulin demand.
Bao, J et al. Food insulin index: physiologic basis for predicting insulin demand evoked by composite meals, Am J Clin Nutr vol. 90, no. 4 986-992
We're talking about the insulin response. RAG & SAG taken together have only a 1in 5 shot of predicting the insulin response.
Carb content, whether simple or complex, refined or unrefined, does not predict the insulin score.
French fries and bananas are the same.
Brown rice and Honeysmacks are the same.
Pasta and muesli are nearly the same.
Brown rice and potato chips are nearly the same.
Other studies have confirmed these findings.
Calrose white 67 15
Calrose brown 51 7
Pelde white 67 11
Pelde brown 55 10
Pelde (parboiled) 57 6
Doongara white 40 10
Doongara brown 39 6
Sunbrown Quick 54 6
Waxy rice 89 19
Rice cakes 73 12
Rice bran 23 4
Brown rice pasta 7218
Wheat pasta 52 9
Rolled oats 54 12
Rolled barley 64 11
Brand-Miller, J et al. Rice: a high or low glycemic index food?, American Journal of Clinical Nutrition, Vol 56, 1034-1036.
White rice and brown rice are nearly the same.
Look.
According to Taubes, one can eat cheese (58) but not bread (62).
One can eat beef (67) but not Special K (71).
One can eat fish (77) but not potato chips (75).
One can eat yogurt (128) but not potatoes (132).
One can eat eggs (37) but not All Bran (36).
I call bullshit.

This message is a reply to:
 Message 398 by Percy, posted 09-02-2011 9:05 PM Percy has seen this message but not replied

molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 418 of 451 (632557)
09-08-2011 1:51 PM
Reply to: Message 398 by Percy
09-02-2011 9:05 PM


Re: Refined v. unrefined insulin response
Because you're exhibiting the same pattern as a couple years ago of citing papers that disagree with you I'm not going to look at the other papers you cited because I think I'll just find more of the same.
Ignore the cites all you want, Percy.
Doesn't change reality one whit.
Carbs do not predict insulin response. 68% of the insulin response is dictated by something other than carbs.
That is the point of the Englyst cite.
Now to the ignored papers.
Milk is insulinogenic.
The novel finding of this experiment was that skimmed milk elicited a disproportionately large insulinaemic response relative to its low glycaemic response in healthy normal subjects.
Certain amino acids (tryptophan, leucine, isoleucine and glutamine) are insulinogenic (Schmid et al. 1989). Hence, it has been hypothesized that elevated concentrations of these amino acids in milk may underlie its insulin-stimulating capabilities (Ostman et al. 2001).
(T)he the insulin scores for milk products have been reported to range from 89 to 115 (Holt et al. 1997; Ostman et al. 2001)
(A)ll dairy products (whole milk, skimmed milk, yoghurt, ice cream, cottage cheese and fermented milk products) have been shown to have potent insulinotropic properties.
Hoyt, G et al. Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk, British Journal of Nutrition (2005), 93, 175—17
Despite low glycemic indexes of 15—30, all of the milk products produced high insulinemic indexes of 90—98, which were not significantly different from the insulinemic index of the reference bread.
Milk products appear insulinotropic as judged from 3-fold to 6-fold higher insulinemic indexes than expected from the corresponding glycemic indexes.
Ostman, E et al. Inconsistency between glycemic and insulinemic responses to regular and fermented milk products, Am J Clin Nutr (2001) 74, 96 — 100.
Again. A big disconnect between the GI & IS.
And, as I mentioned earlier, a huge IS, six times what you would expect, way out of proportion to its carb content.
Cocoa is insulinogenic too. No carbs in cocoa powder!
Although the GI did not differ within each pair, the insulin index (II) of the chocolate product was always higher, by a mean of 28%, than the alternate flavored product.
To our knowledge, this is the first study to demonstrate that chocolate (cocoa powder), has a specific insulinotropic effect, irrespective of food source or the overall macronutrient composition of the food.
Macronutrient composition accounted for nearly all of the variation in GI among the foods, but did not explain differences in insulinemia.
Brand-Miller J, et al. Cocoa Powder Increases Postprandial Insulinemia in Lean Young Adults, The American Society for Nutritional Sciences J. Nutr. 133:3149-3152, October 2003.
Brand Miller is one of the authors of the Holt paper, btw.
Brand Miller goes on to say:
Our findings are consistent with those of other studies in healthy and diabetic individuals (2,4,8,9).
Want me to quote those papers so you can ignore those results too?
Here's another paper that shows there is a big disconnect between GI & IS.
A food that has a low GI can have a high IS. This applies to dairy and to other fatty foods. Some foods (such as meat, fish, and eggs) that contain no carbohydrate, just protein and fat (and essentially have a GI value of zero), still stimulate significant rises in blood insulin.
Oku, T et al. Consideration of the validity of glycemic index using blood glucose and insulin levels and breath hydrogen excretion in healthy subjects, International Journal of Diabetes Mellitus Volume 2, Issue 2, August 2010, Pages 88-94
And I didn't bother quoting these papers ...
Jenkins DJA, et al. Lack of effect of refining on the glycemic response to cereals. Diabetes Care 1981;4:509—13.
Liljeberg H, et al. Metabolic responses to starch in bread containing intact kernels versus milled flour. Eur J Clin Nutr 1992;46:561—75.
Heinonen L, et al. The effect of different types of Finnish bread on postprandial glucose response in diabetic patients. Hum Nutr Appl Nutr 1985;39:108—13.
Jenkins DJA, Wolever TMS, Jenkins AL, Lee R, Wong GS, Josse RG. Glycemic response to wheat products: reduced response to pasta but no effect of fiber. Diabetes Care 1983;6:155—9.
... but I would be more than happy to. But one would think the titles alone would tell you what you need to know.
Oh. What the heck! Just a taste!
The blood glucose response to feeding 50-g carbohydrate portions of white and wholemeal bread and white spaghetti was studied in a group of nine diabetic subjects. Blood glucose rises after white and wholemeal bread were identical, but the response after spaghetti was markedly reduced.
Let me boil this down so we don't talk past each other again:
1. The glucose response (GI) and the insulin response (IS) are weakly correlated. Which is a big problem for Taubes' hypothesis.
2. Carbs do not predict insulin response (IS). At best, they predict 32% of the insulin response. That leaves 68% of the insulin response unexplained.
3. Refined and unrefined carbs evoke similar, if not identical, insulin response (IS).

This message is a reply to:
 Message 398 by Percy, posted 09-02-2011 9:05 PM Percy has seen this message but not replied

molbiogirl
Member (Idle past 2662 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 420 of 451 (632576)
09-08-2011 3:38 PM
Reply to: Message 398 by Percy
09-02-2011 9:05 PM


In vitro v. in vivo
It might be worth noting that in contrast to the other paper, this was a study of a narrow food group (cereal products only), and it was done in vitro, not in vivo, in other words, in the laboratory rather than with actual people.
Um. No.
Englyst et al. (2003) correlated twenty-three cereal-based starchy foods for their GI in vivo and their rate of CHO digestion in vitro (asassessed by the content in rapidly available glucose).
Brouns, F et al. Glycaemic index methodology, Nutrition Research Reviews (2005), 18, 145—17.
Close but no cigar!

This message is a reply to:
 Message 398 by Percy, posted 09-02-2011 9:05 PM Percy has replied

Replies to this message:
 Message 421 by Percy, posted 09-08-2011 6:51 PM molbiogirl has not replied

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