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Author Topic:   Genetic Similarities
Mammuthus
Member (Idle past 6496 days)
Posts: 3085
From: Munich, Germany
Joined: 08-09-2002


Message 7 of 10 (66178)
11-13-2003 3:18 AM
Reply to: Message 4 by TheoMorphic
11-12-2003 1:13 PM


Do you mean a specific gene or a type of gene? The distinction is important as polymerases exist in all phyla but have duplicated, diverged, been eliminated, changed function etc.
Here is an example of a extremely widely distributed class of proteins
Gene. 2001 Jun 13;271(1):81-6. Related Articles, Links
Molecular characterization of homologues of both subunits A (SPO11) and B of the archaebacterial topoisomerase 6 in plants.
Hartung F, Puchta H.
Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstrasse 3, D-06466 Gatersleben, Germany.
The Spo11 protein is an eukaryotic homologue of the topoisomerase 6 subunit A from archaebacteria. In yeast Spo11p has been found to bind covalently to double-strand breaks (DSBs) during meiosis. Single homologues of the SPO11 gene exist in various eukaryotes, except plants. Previously, we found in the Arabidopsis thaliana genome two ancient paralogs, AtSPO11-1 and 2. Here we report on the molecular characterization of a third one, AtSPO11-3. This puzzling finding might be explained by the fact that we detected additionally--for the first time outside of the archaebacterial kingdom--a homologue of the subunit B of topoisomerase 6, AtTOP6B. Both AtSPO11-3 and AtTOP6B are abundantly expressed in Arabidopsis and EST comparisons indicate the presence of both genes in various plant species. Via two hybrid studies we could demonstrate that full length AtTop6B is able to interact with AtSpo11-2 and 3 but not with AtSpo11-1. Our data suggest that plants possess in contrast to other eukaryotes an additional archaebacterial kind of topoisomerase.

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 Message 4 by TheoMorphic, posted 11-12-2003 1:13 PM TheoMorphic has replied

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Mammuthus
Member (Idle past 6496 days)
Posts: 3085
From: Munich, Germany
Joined: 08-09-2002


Message 9 of 10 (66189)
11-13-2003 4:26 AM
Reply to: Message 8 by TheoMorphic
11-13-2003 3:39 AM


Hmm...must be slipping if I sound like Brad now...
Ok simple examples, DNA polymerases, topoisomerases, DNA repair enzymes, helicases...genes all necessary for DNA based life, genes present in your boot scum (ever consider cleaning your closet?) all the way up to McFall.

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 Message 10 by MarkAustin, posted 11-19-2003 3:56 AM Mammuthus has not replied

  
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