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Author Topic:   Increases in Genetic Information
Taq
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Message 8 of 193 (697456)
04-25-2013 5:51 PM
Reply to: Message 1 by jbozz21
04-20-2013 3:59 AM


Macro-evolution:
In order for one organism to evolve into a two types of organisms, they have to be separated into two populations and then have enough mutations (that do not hurt or kill the organism and actually change the physiology of the organism) to completely change the organism into two distinguishable types ("kinds") that cannot re-mix their genetic information. They then become two separate "species" That is macro-evolution.
Chimps and humans are exactly what you are looking for. We share a common ancestor, and the differences between us and chimps is due to the mutations that have accumulated in each lineage since genetic flow stopped between the two lineages. We have the genomes of both chimps and humans (as well as other apes), so we know exactly where the mutations occurred in the genome.
Macro evolution with mutations that increase new, useful and/or beneficial genetic information that makes the organism more complex have to both be possible, have happened in the past and happen today in order for all life on earth to have evolved from a single micro-organism.
The differences seen between humans and chimps is exactly what you are looking for.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


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Message 20 of 193 (697524)
04-26-2013 3:22 PM
Reply to: Message 9 by jbozz21
04-25-2013 6:06 PM


yes but the amoeba, doesn't have nearly as many genes that code for proteins as the human genome, which means that these extra base pairs are probably telomeres which don't code for anything, exons or dna that is involved in directing translation and transcription or something else.
Then the potato appears to be more complex than humans. There are about 40,000 genes in the tuber genome:
"Potato (Solanum tuberosum L.) is the world’s most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin."
Genome sequence and analysis of the tuber crop potato | Nature

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Taq
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Posts: 10083
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Member Rating: 5.1


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Message 21 of 193 (697525)
04-26-2013 3:25 PM
Reply to: Message 11 by jbozz21
04-25-2013 6:30 PM


Of course it doesn't work like that, that is why the idea that all life evolved from a common ancestor is a lie. haha.
You have the cart in front of the horse.
Life can evolve from common ancestors even if there is limited genetic flow between lineages. That's the point being made. You are requiring evolution to do something it doesn't need to do.
But anyway to get to your real point, humans and apes cannot reproduce and have children can they?
The real question is do they have children? The answer is no. There is no genetic flow between the two populations which allows for different mutations to accumulate in each population which, over time, results in divergence (i.e. macroevolution).
Edited by Taq, : No reason given.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


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Message 133 of 193 (697758)
04-29-2013 4:33 PM
Reply to: Message 77 by jbozz21
04-28-2013 2:33 AM


Re: No support,,, humbug...
I am sorry I was being sarcastic with my comment, not to excuse myself but that was because Taq was totally missing my point. It doesn't matter how many genes a potato has because it wasn't the first living organism. Despite the fact that potatoes have more genes than a human, A organism that doesn't have the genetic information for arms and legs, head, spleen, kidney and whatever else. Needs to obtain that from somewhere. It has to have more base pairs so it can code for those things.
Firstly, what can we conclude about your arguments related to genome size and gene counts as measures of complexity? They both fail miserably. We can find single celled organisms with hundreds of times more DNA than humans. We can find simple plants that have twice as many genes as we do. In other words, there is no correlation between complexity and size of the genome or number of genes.
Secondly, there is still the chance that the earliest life had a very large genome.
Finally, why can't "arms and legs, head, spleen, kidney and whatever else" come from mutations in already existing genes?
By the way potatoes have more genes than a human because the plant is polyploidy,so many of the genes are duplicated which means that it does not have as many unique protein coding genes.
There is your mechanism for macroevolution.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


(1)
Message 134 of 193 (697759)
04-29-2013 4:35 PM
Reply to: Message 29 by jbozz21
04-27-2013 2:31 PM


No, the question is can they...
This is the second definition from Species Definition and Examples - Biology Online Dictionary
Whether or not they CAN have offspring doesn't matter one whit if they DON'T. What we are looking for is a mechanism by which different mutations will accumulate in each population, and to do that there can not be genetic flow between the two populations. Citing examples where there is no genetic flow meets that criteria. They are separate species because they are genetically isolated and are accumulating population specific mutations.

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Taq
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Posts: 10083
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Member Rating: 5.1


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Message 135 of 193 (697761)
04-29-2013 4:39 PM
Reply to: Message 81 by jbozz21
04-28-2013 3:39 AM


If you skew the difference between macro and micro then you basically make micro-evolution look like macro with lots of time and it is easy to convince people that it is true that way because micro is well observed and "proven". But there is no solid observational evidence whatsoever to support macro-evolution.
Macroevolution is separate microevolutionary events in separate populations. Micro produces macro if there is a lack of genetic flow between the two populations.
For example, the differences seen between the chimp and human genomes are a series of microevolutionary events. Each mutation is a single event that was selected for or was not selected against (i.e. neutral drift). Over time, these microevolutionary events add up until there are major differences between the two populations.
Since you already agree that humans and chimps are different species, would you consider evidence for common ancestry between humans and chimps as a falsification of your claims?

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


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Message 143 of 193 (698137)
05-03-2013 11:05 AM
Reply to: Message 138 by Just being real
05-02-2013 9:00 PM


I’ve been asking for an example of observed mutation that added new never before existed information to the chromosomal DNA of any multi-celled organism that gave it a selective advantage over its relatives.
Find the differences between the humans and chimp genomes. Those are the mutations you are looking for.
Huh? Every bedtime story I’ve ever been told about evolution has the information building up by the process of random mutations (in the genetic code) and natural selection, selecting those traits which give the organism an advantage to survive over the others.
Natural selection is a process whereby information moves from the environment into the the gene pool of a population. Why does one mutation become more common than another? That information is due to environmental pressures.
I have a question for you to consider when it comes to claiming that the antifreeze gene is an example of added new information to the DNA code. If two species in any order are compared, who determines which of the two species are the oldest and possesses the genes of the original configuration?
You compare them to a third species. If two of the species share the same base at a given position then that gives you information on the ancestral sequence.
You cannot use speculated relationship to prove added information, in order to prove relationship.
Relationships are determined using non-funcational DNA. Common ancestry and the function of a specific DNA sequence are two independent conclusions. For example, we can establish common ancestry between humans and apes by comparing endogenous retroviruses which are largely non-funcational. In fact, we don't even need to know what function an endogenous retrovirus may have in each genome in order to test whether or not humans and other ape species share a common ancestor.
Constructing primate phylogenies from ancient retrovirus sequences
The paper cited compares DNA of different species in order to conclude that fish have evolved an antifreeze protein. But in order for the difference between the two sequences to be meaningful, there must be a logical reason, based on observation, to conclude that the two species were in fact related and that the one with the missing antifreeze protein was the original configuration.
The logical reason is the mountains of evidence supporting universal common ancestry such as the ever present nested hierarchy.
My unique genome is a combination of pre-existing genes from my mother and my father. I did not receive some completely new information that did not exist which gave me spider man abilities or the ability to see infrared light. We observe mixing of the existing genes in the gene pool all the time to create new unique combinations within the population. What I am looking for is the adding of new never before existed information that can show that molecules to man evolution is possible.
So you have had the following done?
1. You and your parents' genomes sequenced.
2. Align that sequence.
3. Find the mutations that are specific to you.
4. Tested the genes that these mutations occurred in and tested for changes in function.
Have you done this? If not, I really don't see why we should accept your claims.

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Replies to this message:
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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


Message 148 of 193 (698149)
05-03-2013 11:29 AM
Reply to: Message 144 by jbozz21
05-03-2013 11:20 AM


Percy, humans have always have had the ability to digest lactose. I think what your refering to is the adult human's ability to. We are born with it and then loose it after we stop breast feeding. We stopped loosing the ability as adults when we started drinking other animals milks, mainly cows. So that is not new information just old genes that don't get turned off.
The change in gene expression was due to a mutation. That is new information.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


(1)
Message 149 of 193 (698152)
05-03-2013 11:35 AM
Reply to: Message 146 by Just being real
05-03-2013 11:28 AM


And I explained in post 28 why observation is important in this situation. Perhaps you missed it.
The problem that you have is that we observe a nested hierarchy. This is the very pattern of shared and derived features that we would expect evolution to produce. You are essentially saying that a designer would make it look like evolution happened, even if it didn't. That doesn't make any sense. It is a like a defense attorney claiming that the jury should ignore all of the fingerprint and DNA evidence because God could have planted the evidence at the crime scene in such a way that it is indistinguishable from known natural mechanisms.
Just to be clear here, by mutations do you mean flaws in the replication of existing genes from the human gene pool, or do you mean completely new gene sequences that provide a selective advantage?
By mutations we mean changes in the DNA sequence of your genome as compared to that of your parents. Mutations are random with respect to fitness, so they can be beneficial, neutral, or detrimental. The facts are that each of us are born with mutations, changes in our genomes that did not exist in our parents. This happens in every single generation. Your parents have mutations not found in your grandparents. Your grandparents have mutations not found in your great-grandparents.
Hmmm, I must say I have difficulty believing that anyone began a scientific study on human lactose persistence 5000 years ago, meaningful enough that we can go back to and examine the data collected from all the DNA samples taken of all the humans back then.
The genomes of living humans are a direct record of their ancestry.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


Message 166 of 193 (698372)
05-06-2013 9:45 AM
Reply to: Message 157 by jbozz21
05-04-2013 4:15 PM


In this case the mutation destroyed the genes ability to turn off the lactase producing gene. That is all that mutations do, is they destroy.
So those tens of millions of mutations that separate humans and chimps are examples of where one or the other genome has been destroyed?
Don't think that I am saying that mutations are not ever beneficial, under certain extenuating circumstances they can benefit an organism but it does not make the organism more fit.
So you are saying that none of the places where humans and chimps differ in their genome is beneficial to either species? You really need to explain this.
Do you agree or disagree that the physical differences between humans and chimps is due to the differences in their genome?

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


Message 173 of 193 (698462)
05-07-2013 10:55 AM
Reply to: Message 167 by jbozz21
05-06-2013 11:42 PM


These tens of millions of differences in human/chimp genomes is not due to mutation but to design.
Then please point to a difference that could not be produced by the known mechanisms of mutation. Even more, please evidence this design mechanism and cite examples of it in action. Please explain why this design process would produce a nested hierarchy, and why there are differences between genes that do not affect the amino acid sequence (i.e. synonymous mutations). sfs also makes a very good point related to the bias for CpG mutations which matches what we observe for real mutational processes.
Edited by Taq, : No reason given.
Edited by Taq, : No reason given.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


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Message 174 of 193 (698467)
05-07-2013 11:05 AM
Reply to: Message 169 by jbozz21
05-07-2013 12:08 AM


Plus a vitamin C producing gene DESTROYING mutation is not beneficial mutation that is selected for against those that don't have the mutation. If anything those without the vitamin c mutation are more fit than those without it.
I would really like to see those studies as they applied to the common ancestor where this mutation occurred. Or are you just making this up?
What you need to explain is why all apes, including humans, have the SAME mutation that knocked out the vitamin c synthase pathway.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


Message 175 of 193 (698468)
05-07-2013 11:07 AM
Reply to: Message 168 by jbozz21
05-06-2013 11:50 PM


mild anemia is still anemia.
Deadly malaria is still deadly malaria.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


(1)
Message 187 of 193 (698778)
05-09-2013 1:26 PM
Reply to: Message 179 by Just being real
05-09-2013 2:20 AM


How does this difference demonstrate the "observation" I am talking about Taq?
Those differences are mutations that have occurred in one lineage or the other, and they are responsible for the physical differences between humans and chimps.
You are using circular reasoning here. You are saying in effect that chimps are related to humans via evolution. And that we know evolution is true via differences between chimp and human genomes.
That is false. We determine common ancestry by the PATTERN of similarities and differences. That pattern is a nested hierarchy.
How do you "know" that is what that means Taq? No one observed which specie is the oldest and therefore it is merely an assumption.
Not an assumption. It is a conclusion drawn from constructing phylogenies. Chimps and humans have a much more recent common ancestor than humans and gorillas, and the even more distantly related orangutan. These are all conclusions drawn from real life data using real genetic techniques, not assumptions.
A conclusion drawn completely on similarity arguments which do not aid in the debate between intelligent design or evolution.
Why doesn't it aid in the debate?
No this is what one would expect if a highly intelligent designer were responsible for creating all forms of life to all exist and function within the same biosphere. The auto manufacturer known as Saab also once created aircraft.. Just because there are some similarity between the two forms of transportation does not imply that Saab intentionally meant to deceive us into thinking evolution had occurred.
Cars and airplaines made by Saab do not fall into a nested hierarchy. Human designs do not fall into a nested hierarchy. There is absolutely no reason why any designer would be forced to limit designs to a nested hierarchy. However, that is the only pattern of shared and derived features that evolution can produce.
What do we see with life? Life falls into a nested hierarchy just as we would expect from the process of evolution and not intelligent design.
Look Taq, I don't care how many ways you randomly change the "Roses are red violets are blue" poem, It will never become the classic novel "Wuthering Heights," unless a good deal of new information is added along with the changes.
No one is claiming that poems evolve from one another through mutation and selection. We are talking about DNA which is not a poem.
Likewise you can't get from bacteria to humans just by changing DNA sequences.
Evidence please.
I am saying that this process has never been observed that I know of.
Of course not. This is because you define any change in DNA sequence as a loss in information. You have really defined yourself out of the debate. Using your definition of an "increase in information", evolution does not need to increase information as you define it in order to produce the biodiversity we see around us. The mutations that separate species are all that is needed.

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Taq
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Posts: 10083
Joined: 03-06-2009
Member Rating: 5.1


Message 188 of 193 (698779)
05-09-2013 1:29 PM
Reply to: Message 180 by Just being real
05-09-2013 2:21 AM


Re: Nuclear contamination?
Yes if it can be shown that such a mutation actually added new information to the genome which gave the organism a selective advantage over its relatives, then I would agree. But what I was describing was not anything like that.
That is exactly what we have with the differences found between the human and chimp genome.
Perhaps you can tell us why these differences could not be produced by the observed processes of evolution?

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