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Author Topic:   Molecular Population Genetics and Diversity through Mutation
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(2)
Message 360 of 455 (786031)
06-14-2016 9:59 PM
Reply to: Message 355 by Faith
06-14-2016 9:14 PM


Re: Mutations are not alleles
Let's try this again.
Selection. Decreases. Genetic. Diversity.
Mutation. Increases. Genetic. Diversity.
If only the first of these processes existed, we would indeed see an inevitable monotonic decrease in genetic diversity. But it doesn't, so we don't. If we choose only to "focus on" the first of these processes, this does not actually alter reality, because reality doesn't care which bits of it you ignore.

This message is a reply to:
 Message 355 by Faith, posted 06-14-2016 9:14 PM Faith has replied

Replies to this message:
 Message 361 by Faith, posted 06-14-2016 10:00 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 362 of 455 (786033)
06-14-2016 10:05 PM
Reply to: Message 359 by Faith
06-14-2016 9:56 PM


Re: Mutations are not alleles
You are seriously delusional if you think you understand anything of what I've been arguing.
Well, I and everyone else reading your innumerable threads on this subject understand you to be claiming that evolution requires a loss of genetic diversity and that this depletion must necessarily bring evolution to a halt when the genetic diversity runs out. Because that is what you keep saying. If your argument is actually that carnivorous petunias are stealing your elbows, then you would be well advised to use different words from those you have hitherto been employing.

This message is a reply to:
 Message 359 by Faith, posted 06-14-2016 9:56 PM Faith has not replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


Message 363 of 455 (786034)
06-14-2016 10:07 PM
Reply to: Message 361 by Faith
06-14-2016 10:00 PM


Re: Mutations are not alleles
You are seriously delusional if you think your little formula is any kind of answer to what I've been arguing.
Well, I and everyone else reading your innumerable threads on this subject understand that mutation increases genetic diversity. Because it does.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 361 by Faith, posted 06-14-2016 10:00 PM Faith has replied

Replies to this message:
 Message 364 by Faith, posted 06-14-2016 10:21 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


Message 366 of 455 (786037)
06-14-2016 10:31 PM
Reply to: Message 364 by Faith
06-14-2016 10:21 PM


Re: Mutations are not alleles
No it doesn't and if you understood the argument you'd know why it doesn't.
No amount of arguing that a process that by definition increases genetic diversity doesn't increase genetic diversity will stop it from increasing genetic diversity.

This message is a reply to:
 Message 364 by Faith, posted 06-14-2016 10:21 PM Faith has replied

Replies to this message:
 Message 372 by Faith, posted 06-15-2016 10:02 AM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 411 of 455 (786528)
06-22-2016 5:54 PM
Reply to: Message 372 by Faith
06-15-2016 10:02 AM


Re: Once again now, evolution of new phenotypes REQUIRES loss of genetic diversity
To get a new subspecies, species or breed requires the loss of genetic diversity. If it isn't lost or at least reduced, you don't get a subspecies, species or breed. In nature the purest way this occurs is by geographic isolation. Domestic breeders do it by intentional mating. An increase in genetic diversity in either case will blur the emerging phenotypes, and as long as reproductive isolation is maintained there is no reason to have an increase.
The occasional mutation, assuming it gets expressed as a phenotype, is easily removed from the breed. But most won't get expressed as phenotypes. Mutations that do that are rather rare as I understand it. And most are something neither nature nor the domestic breeder would find helpful anyway. You get a breed or a new species by LOSS of genetic diversity. That's how it happens.
If you don't want a breed you don't have to have one, you can have all the genetic diversity you like, but enough to make up for the loss required to bring out a new breed would destroy the breed entirely. If that's what you want as a breeder, you can have it, you just won't have your breed, you'll have something else.
In nature if gene flow between populations continues while a population has at least partial reproductive isolation, you may get a recognizable breed, but reproductive isolation that prevents gene flow should bring out the most dramatic new phenotypes.
In other words if you DO get mutations as you expect they'll increase the genetic diversity somewhat to change your species or breed, and if it's enough mutations to make up for the loss in arriving at the new species or breed you'll just not have that species or breed at all. You'll be back at Square One as far as evolution of new species goes.
Possibly the blue wildebeest emerged from the black by some of the black simply getting separated from the parent black population for some number of generations while their collective new gene frequencies brought out the blueish coloring, the new body build and the new antler style. Some gene flow might not impede the process too much but the ideal condition, or at least the clearest condition to explain, is complete reproductive isolation for producing the new species of wildebeest.
It's a very simple and obvious formula: losing genetic diversity is what gets a new subspecies in the wild or a breed in domesticity. There's no problem with this unless you lose a LOT of genetic diversity. And a new species/population such as the blue wildebeest, could in fact be stable for hundreds of years. This is all hypothetical, I'm talking about how it could have happened. Reality is usually messier, of course, involving continued gene flow for instance, but the trend that brings out new species is the LOSS of genetic diversity.
If you have a large population with lots of genetic diversity and many viable mutations, it will be a motley collection of many phenotypes. It could only become a new species if selection or some kind of reproductive isolation favored a particular set of phenotypes out of the whole collection of phenotypes, over many generations, creating a new subpopulation with its own characteristics, perhaps even within the greater population. And that subpopulation will lose the genotypes for the NONfavored or unselected phenotypes, as those for the favored/selected come to characterize the new subpopulation. There is no way to get a new phenotypic presentation without such a loss.
I really don't know if you are obtuse or willfully pretending to be. If pretending, that's understandable, of course, in a diehard evo who couldn't bear to find out the ToE is wrong and there is a God who constructed this biological pattern, because this is definitely a pattern that contradicts the ToE and shows that it could never work.
I am aware of your dogma. You are still ignoring the fact that mutations increase genetic diversity. What you have shown is that if you remove mutations from the theory of evolution, you are left with an abortive theory that doesn't work. We knew that. But as you cannot effect a corresponding removal of mutations from reality, your botched and stunted theory of how evolution happens has no relevance to the world we actually live in.

This message is a reply to:
 Message 372 by Faith, posted 06-15-2016 10:02 AM Faith has replied

Replies to this message:
 Message 413 by Faith, posted 06-22-2016 5:59 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


Message 412 of 455 (786529)
06-22-2016 5:55 PM
Reply to: Message 409 by Faith
06-22-2016 4:44 PM


Re: A serious question for Faith
I was actually addressing Dr. A's statements ...
Oh, I wouldn't go that far.
Clearly you DON'T understand since you still think it stands. Periods of increase can happen of course, but during those periods you are not getting selection, isolation or indeed evolution, meaning change in a whole population, WHICH IS WHAT MY ARGUMENT IS ABOUT.
But ignoring the periods of increase does not prevent them from happening, which means they need to be taken into account if we do not wish to make total assswits of ourselves.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 409 by Faith, posted 06-22-2016 4:44 PM Faith has not replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(3)
Message 414 of 455 (786532)
06-22-2016 6:25 PM
Reply to: Message 413 by Faith
06-22-2016 5:59 PM


Re: Once again now, evolution of new phenotypes REQUIRES loss of genetic diversity
You are certainly very good at saying absolutely nothing as if you were saying something. I don't deny that mutations increase genetic diversity, what I deny is that it changes my argument.
Well, was this not your argument?
Faith, message#4 writes:
If evolution, meaning the production of a population-wide change in phenotypic presentation (black wildebeests to blue wildebeests, normal lizards to large-headed lizards, Darwin’s finches and so on, all changes normally called evolution) always requires a reduction in genetic diversity, that is obviously contrary to what evolution needs in order to do what the ToE says it does.
Now, if mutations increase genetic diversity, which they do, then this supplies "what evolution needs in order to do what the ToE says it does". Obviously. Darwin called his idea "the theory of descent with modification through variation and natural selection". The variation exists, and so the theory works. Ignoring it won't make it go away. Shouting and stamping your feet won't make it go away. Telling us in capital letters that that's not what your argument's about will not make it go away, but will tell everyone that your argument is predicated on willful blindness to incontrovertible facts. Then they will point at you and laugh.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 413 by Faith, posted 06-22-2016 5:59 PM Faith has replied

Replies to this message:
 Message 415 by Faith, posted 06-23-2016 12:00 AM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(2)
Message 416 of 455 (786543)
06-23-2016 2:27 AM
Reply to: Message 415 by Faith
06-23-2016 12:00 AM


Re: Once again now, evolution of new phenotypes REQUIRES loss of genetic diversity
That would only be true, assuming the additions were viable, which they aren't ...
Once again,my friend Mr. Direct Observation begs to differ.
which they aren't but anyway, it would only be true IF the reduction in genetic diversity was not necessary to make new species.
Uh, no.
In order for selection to take place, there needs to be a variety of genotypes to select from. Mutations supplies these. The fact that selection is required to produce new species does not mean that mutation does not provide the variety that is selected from. Because why would it?
Variation of phenotypes requires reduction of genetic variability.
That is a very odd collection of words.
Darwin didn't realize that selection requires this reduction.
Darwin realized that selection was a selective process which selects for some variations and against others. This is why he called it selection. And ever since then, everyone who has undertaken even the most cursory study of evolution has understood it. I understand it. All the geneticists in the world understand it. Even you understand it.
What makes you unique is that you cannot also grasp what Darwin and I and all the geneticists everywhere can grasp: that if there is a constant supply of new variation, natural selection will never run out of variation to select from.
Again, variation according to Darwin (and me) is the emergence of new phenotypes, it has nothing to do with adding genetic diversity.
If you can quote Darwin saying that or anything remotely like it, I shall eat my hat. But if, as I suspect, you are just making shit up, my hat will remain unscathed.
I really truly can't believe you are this dense.
I am indeed not dense. Nor are all the geneticists in the world. Indeed, if you thought about it for a moment you might begin to suspect that if anyone is being dense, it's the woman who disagrees with all the geneticists about genetics while being repeatedly unable to define such fundamental terms as "mutation".

This message is a reply to:
 Message 415 by Faith, posted 06-23-2016 12:00 AM Faith has replied

Replies to this message:
 Message 422 by Faith, posted 06-23-2016 6:14 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


Message 417 of 455 (786544)
06-23-2016 2:56 AM


Example?
It is hard to understand what is going on in your mind, Faith.
Talk me through an example. You suppose, do you not, that the alleles for (e.g.) Dalmatians were present in wolves from Creation Week on, that they survived the bottleneck of the Flood, and then thousands of years later someone in Croatia decided to select for Dalmatian-y phenotypes and so create the Dalmatian breed.
But what if instead the alleles arose much more recently, by mutation, and then someone in Croatia decided to select for Dalmatian-y phenotypes and so create the Dalmatian breed. Why wouldn't that work out just as well for the dog breeder? How would it matter when or how the variation arose? Surely for the purposes of creating the breed, all that matters is that it's there?
If not, please explain why not.
Edited by Dr Adequate, : No reason given.

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


Message 421 of 455 (786591)
06-23-2016 5:47 PM
Reply to: Message 420 by Faith
06-23-2016 4:28 PM


Re: Forgetful?
And your use of capital letters does nothing to prevent mutations from adding genetic diversity.

This message is a reply to:
 Message 420 by Faith, posted 06-23-2016 4:28 PM Faith has not replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 423 of 455 (786598)
06-23-2016 6:42 PM
Reply to: Message 422 by Faith
06-23-2016 6:14 PM


Re: Once again now, evolution of new phenotypes REQUIRES loss of genetic diversity
Or they are built in from Creation.
Well, we can see mutations occurring.
The fact that selection is required doesn't mean it couldn't be mutations that provide the variety ...
Thank you.
AND EVEN IF IT IS TRUE, it doesn't matter because the selective processes that bring about the new species will always reduce it and that will always be the overall trend of those processes ...
Well, show your working.
You admit now that there are two processes, one of which adds diversity, the other of which subtracts it. If you maintain that there must be some tendency for the latter to win (contrary to reason and observation) then you are obliged to demonstrate and not merely assert this.
What is not understood is that selecting for some variations and against others means the loss of the genotypes for the others. Nothing is added, only lost, in the selection of some variations over others.
That is plainly understood. I understand it. All geneticists understand it. Everyone who knows what the word "selection" means understands it. Even you understand it.
What makes you unique is not that you (like everyone else) understand the role of selection but that you (unlike everyone else) do not understand the role of variation.
his is what was wrong with your "refutation" of my argument by the picture of all the dog breeds. Each of those breeds has only a small selected portion of the genetic diversity in the whole dog population, and it's the BREEDS that are "evolving," showing that evolution of new types requires that loss. It's in EACH breed that the argument is made. It's THERE that you see the formation of new phenotypes. It is THERE that evolution is going on. It really matters not one whit what the source of the genetic diversity is from which the breed is selected ...
Thank you. Very well then. If you can imagine evolution of all those breeds from a couple of wolves front-loaded with variation, then you can also imagine a subpopulation of dogs acquiring that much variation again through mutation, and so giving rise to as many new breeds. And the process need never stop.
But then you want to add mutations and destroy those breeds? But then you don't have the platform for further evolution, you're back at Square One.
Well, that's a funny way of putting it? Is the human species "destroyed" by having many races? Are chihuahuas "destroyed" by having all those different colors and patterns? Is Canis lupus "destroyed" by exhibiting the genotypes for all those breeds?
(The odd thing is, of course, that if you think that genetic diversity "destroys" a species, then since you also think that God front-loaded the diversity, you must conclude that God created "destroyed" species to start with, and that we would undestroy them by extirpating the genetic diversity.)
I've tried many times to create a graphic representation of this. I always find some way I'm misrepresenting what I want to represent and have to start over. And Paint is a klutzy medium which makes representing sufficient numbers to get across the point especially difficult.
Well of course you can't represent it. Your words don't correspond to anything concrete, or even to something that could be given a concrete representation.
The problem is that geneticists, biologists, geologists etc. all subscribe to the ToE and always think according to its principles no matter how false and misleading they are. This gives you all a certain denseness when it comes to thinking outside the box.
The "box" is the known facts of genetics.

This message is a reply to:
 Message 422 by Faith, posted 06-23-2016 6:14 PM Faith has replied

Replies to this message:
 Message 427 by Faith, posted 06-23-2016 8:12 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(3)
Message 425 of 455 (786603)
06-23-2016 7:40 PM
Reply to: Message 424 by Faith
06-23-2016 7:30 PM


Re: An attempt at a simple illustration
And if mutations are also contributing to that diversity a lot more. But you don't have your new flower, your new variety.
If so many mutations arose and were fixed that we would say that the variety had turned into a completely new variety, that would be an example of evolution.
What can I say? Your point seems to be that mutations will keep evolution going; and that if evolution keeps going, then it won't stop at any particular point. Which is kinda what I've been trying to tell you.

This message is a reply to:
 Message 424 by Faith, posted 06-23-2016 7:30 PM Faith has not replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 428 of 455 (786606)
06-23-2016 9:30 PM
Reply to: Message 427 by Faith
06-23-2016 8:12 PM


Re: Once again now, evolution of new phenotypes REQUIRES loss of genetic diversity
It's not a matter of "winning," it's that you can ONLY get a new breed or variety or species by subtracting, and if instead you add you will lose the breed or variety or species.
And yet the human race have not been "lost" by the acquisition of different colors.
Do you picture evolution as a process of making breeds/species and losing them then? Isn't it supposed to proceed by building upon what's already been established? If you add mutations you aren't building, you are losing the species you already had.
No, you are increasing the variety of the species. Which is evolution. If selection then picks out these new varieties and fixes them, replacing the old ones, this may go so far as to produce a completely different species. Which is evolution. Or if this only happens in an isolated population of the species, then you get a new species and keep the old one. Which is evolution.
Again, your point seems to now be that yes, mutation happens, and yes, that means that evolution will never stop --- but that you consider this to be a bad thing. I can really make no more of your argument.
Mutations don't add "many races," they just change the existing race or breed or variety etc.
That depends on whether they go on to be fixed in the species.
They aren't thinking of reduction of genetic diversity at all, of loss at all ...
Yes they are. They are aware of natural selection. I am aware of natural selection. All geneticists are aware of natural selection. Darwin was aware of natural selection. Everyone who was paying attention during biology is aware of natural selection. Even you are aware of natural selection.
What makes you different from us is not that you (like us) are able to grasp the role that natural selection plays in evolution, but that you (unlike us) are unable to grasp the role that variation plays in evolution.
It's ADDING genetic diversity when you already have a breed or variety or species that destroys that breed or variety or species.
But why does it matter where the diversity comes from? If a species is to be considered "destroyed" when it has a certain amount of diversity, then why does it matter whether the diversity that "destroys" it comes from God or from observable natural processes?
Incidentally, can you tell us how much diversity does destroy a species?
Edited by Dr Adequate, : No reason given.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 427 by Faith, posted 06-23-2016 8:12 PM Faith has replied

Replies to this message:
 Message 431 by Faith, posted 06-23-2016 10:18 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(4)
Message 429 of 455 (786607)
06-23-2016 9:44 PM


Graphical Representation
Here is a graphical representation. It is, of course, schematic: for example, real viable populations are bigger.
Note that when we stop the music, we have no organism that is identical with any member of the original population. If you like, you may say it has been "lost". Yeah, that's 'cos evolution has happened.
Note also that neither population, still less the clade as a whole, has decreased in variation, 'cos why would they? They could, but you have yet to produce a reason why they should.
Edited by Dr Adequate, : No reason given.
Edited by Dr Adequate, : No reason given.

Replies to this message:
 Message 432 by Faith, posted 06-23-2016 10:23 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 306 days)
Posts: 16113
Joined: 07-20-2006


(3)
Message 433 of 455 (786612)
06-23-2016 10:56 PM
Reply to: Message 432 by Faith
06-23-2016 10:23 PM


Re: Graphical Representation
Yours is basically undecipherable.
Does anyone else on this thread have any problem understanding it?
No? Just Faith?
What don't you understand, Faith?
I've many times tried to construct a similar graphic representation. It doesn't work.
I think I can do it. Yours would look like this:
But since mutation exists, there is no likelihood, let alone a necessity, that anything like that would actually take place.

This message is a reply to:
 Message 432 by Faith, posted 06-23-2016 10:23 PM Faith has not replied

  
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