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Author Topic:   The great basic question of science on origin of life
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 43 of 64 (776773)
01-20-2016 12:24 AM
Reply to: Message 42 by RAZD
01-19-2016 1:50 PM


Silence
quote:
I get the impression that he is concerned about something that he feels is being ignored by the specialists, and that he is looking for answers more than saying he has them.

All the experts are trying to solve the problem of the origin of life only through protocells as the membrane compartments. For this they need in self-generation of sodium pump. Nobody watched such self-generation. Nobody knows what is to be done for that. Prior to the publication, I asked for 60-70 specialists in the West: in which point I'm wrong? All (all!) of them chose to remain silent.

Edited by Vladimir Matveev, : No reason given.


This message is a reply to:
 Message 42 by RAZD, posted 01-19-2016 1:50 PM RAZD has not yet responded

Replies to this message:
 Message 44 by Percy, posted 01-20-2016 7:50 AM Vladimir Matveev has responded
 Message 46 by Pressie, posted 01-20-2016 8:30 AM Vladimir Matveev has responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


(1)
Message 45 of 64 (776788)
01-20-2016 7:55 AM
Reply to: Message 44 by Percy
01-20-2016 7:50 AM


Re: Silence
quote:
Pick yourself up, dust yourself off, and get back to work researching and developing more effectively persuasive evidence and arguments.

Of course, I continue to work. Thank you!

This message is a reply to:
 Message 44 by Percy, posted 01-20-2016 7:50 AM Percy has acknowledged this reply

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 47 of 64 (776795)
01-20-2016 9:29 AM
Reply to: Message 46 by Pressie
01-20-2016 8:30 AM


Re: Silence
quote:
Really? That's not the impression I got from the work of specialists such as Craig Venter and his labs. Has he reviewed your work?

A Reviwer rejected my MS wrote: "Dr. Matveev is convinced that the best model of a precellular structure are the so-called Fox microspheres, a belief that is shared by very few researchers nowadays, many of which are convinced that liposomes, micelles and equivalent microstructures are a much more realistic model of precellular structures."
As to Craig Venter, peer review is anonymous. This Craig Venter (http://sandwalk.blogspot.ru/...r-discusses-tree-of-life.html) is far from physical aspects of the origin of life.

This message is a reply to:
 Message 46 by Pressie, posted 01-20-2016 8:30 AM Pressie has not yet responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 49 of 64 (788892)
08-07-2016 12:29 AM
Reply to: Message 48 by Blue Jay
01-20-2016 11:43 AM


Oral presentation
Vladimir Matveev. The great basic question of science: Membrane compartment or non-membrane phase compartment is a physical basis for origin of life?
Oral presentation at The 2nd All-Russian Conference on Astrobiology. Moscow, Pushchino, 5-9 June 2016.
Video in English: https://youtu.be/Hn7A-1w0tuQ

Presentation slides in English as pdf:
http://www.bioparadigma.spb.ru/....of.science_Eng_Slides.pdf

Comments for slides in English:
http://www.bioparadigma.spb.ru/...f.science_Comments_Eng.pdf


This message is a reply to:
 Message 48 by Blue Jay, posted 01-20-2016 11:43 AM Blue Jay has not yet responded

Replies to this message:
 Message 50 by Genomicus, posted 08-07-2016 3:49 AM Vladimir Matveev has responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 51 of 64 (788902)
08-07-2016 5:16 AM
Reply to: Message 50 by Genomicus
08-07-2016 3:49 AM


Re: Oral presentation
I'm probably missing something here, but I'm not sure I quite see what specific problem your model solves.

Hey, Genomics,

Phase approach has full experimental evidences in support of. Membrane approach has no such evidences. My (phase) model disproves membrane approach. However, the membrane approach is commonly accepted approach to solving the problem of the origin of life. This is my main contribution. Thanks for the answer.


This message is a reply to:
 Message 50 by Genomicus, posted 08-07-2016 3:49 AM Genomicus has not yet responded

Replies to this message:
 Message 52 by Pressie, posted 08-08-2016 7:30 AM Vladimir Matveev has responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 53 of 64 (788941)
08-08-2016 7:53 AM
Reply to: Message 52 by Pressie
08-08-2016 7:30 AM


Re: Oral presentation
"So, you agree that life was not poofed into existence."

Biophase is the physical basis of life, and therefore it originated on this basis and exists on the same basis.

Please see my presentation for details. Thanks.


This message is a reply to:
 Message 52 by Pressie, posted 08-08-2016 7:30 AM Pressie has responded

Replies to this message:
 Message 54 by Pressie, posted 08-08-2016 8:27 AM Vladimir Matveev has responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 55 of 64 (788944)
08-08-2016 12:12 PM
Reply to: Message 54 by Pressie
08-08-2016 8:27 AM


Re: Oral presentation
"So, you agree that life was not poofed into existence?"

Nobody knows the answer to this question. Fundamentally important question: what is the correct model of the living cell.


This message is a reply to:
 Message 54 by Pressie, posted 08-08-2016 8:27 AM Pressie has responded

Replies to this message:
 Message 56 by Pressie, posted 08-11-2016 8:12 AM Vladimir Matveev has not yet responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 60 of 64 (789305)
08-12-2016 11:51 PM
Reply to: Message 59 by Genomicus
08-12-2016 9:04 AM


Re: Oral presentation
His model is based on the adsorption of water molecules on polypeptide surfaces. No poofing involved.

Genomics, please give us a model which is proved as the cradle of life.


This message is a reply to:
 Message 59 by Genomicus, posted 08-12-2016 9:04 AM Genomicus has responded

Replies to this message:
 Message 61 by Genomicus, posted 08-21-2016 4:21 PM Vladimir Matveev has responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 62 of 64 (789901)
08-22-2016 2:19 AM
Reply to: Message 61 by Genomicus
08-21-2016 4:21 PM


Re: Oral presentation
Genomics: "...it still leaves a lot to explain, like the origin of gram-positive and gram-negative membrane structures."

Fox's microspheres are gram-positive and gram-negative protocells: http://jb.asm.org/content/85/2/279.full.pdf
It is good point to start.

Please give us paper(s) with gram-positive and gram-negative proto-membrane structures. Thanks.

Edited by Vladimir Matveev, : No reason given.


This message is a reply to:
 Message 61 by Genomicus, posted 08-21-2016 4:21 PM Genomicus has responded

Replies to this message:
 Message 63 by Genomicus, posted 08-22-2016 3:28 AM Vladimir Matveev has responded

  
Vladimir Matveev
Junior Member (Idle past 1561 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015


Message 64 of 64 (789905)
08-22-2016 4:01 AM
Reply to: Message 63 by Genomicus
08-22-2016 3:28 AM


Re: Oral presentation
But that doesn't explain the transition from gram-positive prokaryotes to gram-negative prokaryotes. In other words, just imagining the origin of a simple membrane bag does nothing to explain the origin of the earliest life forms empirically known to exist -- bacteria.

Anyways, I'm still a little confused about your model. How does your model explain the origin of (1) the first membrane-bound cell systems, (2) the origin of ATPases and other early molecular machinery?

Nobody explanes these things you want to be explaned. If you watched my oral presentation (https://youtu.be/Hn7A-1w0tuQ) you know that I have many quastions too without any excplanations.

You missed my main idea: the first step in the origin of life is the creation of the physical conditions necessary for life. Only after that evolution can begin (the origin of different types of cells, enzymes and ATPases, etc.). According to the membrane approach, the necessary physical conditions can only occur when there is sodium pump in plasma membrane. This is the first step according to this approach. If this step is not passed, no evolution is possible because only the living cell can evolve. There is no experimental evidence of origin of sodium pump in prebiotic conditions. If there is no such evidence, then the membrane approach is not confirmed. Other questions I have formulated here: http://www.bioparadigma.spb.ru/...Preview.and.Highlights.pdf
I'm talking only about the first step in the origin of life. You talk about life itself.

Edited by Vladimir Matveev, : No reason given.

Edited by Vladimir Matveev, : No reason given.


This message is a reply to:
 Message 63 by Genomicus, posted 08-22-2016 3:28 AM Genomicus has not yet responded

  
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