Hi Gang,
You might try googling on "London mosquito"
In a nutshell, Culex pipines was the dominant mosquito species in London prior to the Tube (subway) being built at the end of the 19th century. With the completion of the Tube, the mosquitos followed their human hosts underground. Since the subway trains ran on regular schedules, there was no need for the mosquitoes to come up to find a meal. Not only did they stay underground, their diet was restricted mainly to humans, they bred in stagnant underground puddles and lived and died in artificial light.
By the 1980s or so, this underground variety of mosquito was found to be completely sexually isolated from the above-ground stock from which it started.
This is a rough summary mind you, so someone better versed in entomology might help fill in the blanks.
Anyway, as I understand the definition of "macro evolution" as relating to the generation of new species, this one may qualify.
(:raig