The key phrase is "makes sense". Sure, you can fiddle around in biology and do things by trial and error without it "making sense". But you can't make useful predictions about likely outcomes unless it "makes sense" in some way.
Creationism falls back on a gigantic question mark in the sky which doesn't explain anything. If it hasn't already told you the answer, you have no way of predicting what it might be. You have nothing but trial and error to work with.
Evolution is the only explanation of biology that "makes sense".