All commercial gambling is designed to bring in more money than it pays out. Unless there is a way to take advantage of the systems the odds are against you. In State Lotteries there is no legal way to take advantage of the system. Count any money you put into that as part of your entertainment budget and count it as spent.
In a typical second chance drawing you’ve already paid for the ticket so unless there is some extra charge or expense it probably makes sense to go for it. If there are additional charges or expenses you should pay them out of your gambling budget - instead of using it to buy more tickets. Whether that is a less bad use of the money I couldn’t say without knowing a whole lot more.
The best way to play the system, on the other hand, depends on the system. And that varies.
I can’t imagine the probabilities changing if tickets are entered at spaced intervals unless there are multiple draws.
Entering 100 tickets should improve the odds (assuming the draw is from the tickets).