Gene variant activity is surprisingly variable between tissues
Every gene in (almost) every cell of the body is present in two variants -- so called alleles: one is deriving from the mother, the other one from the father. In most cases both alleles are active and transcribed by the cells into an RNA message. However, for a few genes, only one allele is expressed, while the other one is silenced. The decision whether the maternal or the paternal version is shut down occurs early in embryonic development -- one reason, why for long it was thought that the pattern of active alleles is nearly homogeneous in the various tissues of the organism.
The new study (DOI:10.7554/eLife.25125), where CeMM PhD Student Daniel Andergassen is first author (now a PostDoc at Harvard University), uncovers a different picture. By performing the first comprehensive analysis of all active alleles in 23 different tissues and developmental stages of mice, the team of scientists revealed that each tissue showed a specific distribution of active alleles. https://www.sciencedaily.com/...ses/2017/08/170818092138.htm
A forthcoming book by biologist J. Scott Turner, Purpose & Desire: What Makes Something “Alive” and Why Modern Darwinism Has Failed to Explain It, is a real shot across the bow of modern evolutionary biology.
"....writing his third book, currently titled "Biology's Second Law: Evolution, Purpose and Desire", which builds the case that evolution operates through the complementary principles of Darwinian natural selection (biology’s "First Law") coupled to homeostasis (biology’s "Second Law")."
He at least seems like a real scientist but he's funded by the Templeton Foundation which is a very large flashing red light.
Je suis Charlie. Je suis Ahmed. Je suis Juif. Je suis Parisien. I am Mancunian. I am Brum. I am London.I am Finland. Soy Barcelona
"Life, don't talk to me about life" - Marvin the Paranoid Android
"Science adjusts it's views based on what's observed. Faith is the denial of observation so that Belief can be preserved." - Tim Minchin, in his beat poem, Storm.
This is a series of 12 short videos, each a couple/few minutes long and which briefly answer some common questions about and objections to evolution.
The titles are:
#1 What Is Evolution, Anyway? #2 Is Evolution Random? #3 Have We Ever Seen Evolution Happen? #4 Can Evolution Make an Eye? #5 Have We Ever Seen A New Species Arise? #6 Evolution Is Dumb #7 Why Do Men Have Nipples? #8 Does Evolution Violate the 2nd Law of Thermodynamics? #9 Can Evolution Create Information? #10 Why Are There Still Monkeys? #11 Are Humans Still Evolving? #12 Does Evolution Have a Point?
In the comments section of the last video, I found this little ditty:
quote: On the 12th day of Evolution, Darwin's Beard gave to me: 12 evolutionary potentials , 11 "yes we're changing"s, 10 evolutionary branches, 9 duplicate genes, 8 thanks to entropy, 7 looks at nipples, 6 good enough traits, 5! Isolated Mosquitos! 4 light sensitive organelles, 3 silent crickets, 2 DNA blue prints, & an explanation of evolution.
BTW, the title screen is a sketch of Darwin with an extra-long beard in which we see 12 finches nesting. I didn't try it, but apparently you can choose any of the 12 videos by clicking on the appropriate finch.