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Author Topic:   Link to Autism
RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


(1)
Message 1 of 9 (856279)
06-29-2019 10:00 AM


quote:
Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by glia over-proliferation, neuro-inflammation, perturbed neural circuitry, and gastrointestinal symptoms. The role of gut dys-biosis in ASD is intriguing and should be elucidated. We investigated the effect of Propionic acid (PPA), a short-chain fatty acid (SCFA) and a product of dys-biotic ASD gut, on human neural stem cells (hNSCs) proliferation, differentiation and inflammation. hNSCs proliferated to 66 neuropsheres when exposed to PPA versus 45 in control. The neurosphere diameter also increased at day 10 post PPA treatment to (Mean: 193.47”um SEM: 6.673”um) versus (154.16”um 9.95”um) in control, p”<”0.001. Pre-treatment with -HB, SCFA receptor inhibitor, hindered neurosphere expansion (p”<”0.001). While hNSCs spontaneously differentiated to (48.38% 6.08%) neurons (Tubulin-III positive) and (46.63% 2.5%) glia (GFAP positive), PPA treatment drastically shifted differentiation to 80% GFAP cells (p”<”0.05). Following 2”mM PPA exposure, TNF- transcription increased 4.98 fold and the cytokine increased 3.29 fold compared to control (P”<”0.001). Likewise, GPR41 (PPA receptor) and pro-survival p-Akt protein were elevated (p”<”0.001). PTEN (Akt inhibitor) level decreased to (0.42”ug/ul 0.04”ug/ul) at 2”mM PPA compared to (0.83”ug/ul 0.09”ug/ul) in control (p”<”0.001). PPA at 2”mM decreased neurite outgrowth to (80.70”um 5.5”um) compared to (194.93”um 19.7”um) in control. Clearly, the data supports a significant role for PPA in modulating hNSC patterning leading to gliosis, disturbed neuro-circuitry, and inflammatory response as seen in ASD.
Full article follows abstract in link.
quote:
New research sheds light on a possible cause of autism: processed foods
  • A new study from the University of Central Florida makes the case for the emerging connection of autism and the human microbiome.
  • High levels of Propionic Acid (PPA), used in processed foods to extend shelf life, reduces neuronal development in fetal brains.
  • While more research is needed, this is another step in fully understanding the consequences of poor nutrition.
A new study from the University of Central Florida, published in Scientific Reports on June 19, makes the case for the emerging connection of autism and the human microbiome. High levels of Propionic Acid (PPA), which is used in processed foods to extend shelf life and inhibit the growth of mold, appears to reduce neuronal development in fetal brains.
The number of children diagnosed with ASD has been ticking up by the year, though as Silberman writes, the spectrum is not new. Still, something is changing in societies causing this surge. In 2000, the CDC observed one out of every 150 children exhibiting such behaviors; by 2018, that number climbed to one of out every 59.
So it seems that High levels of Propionic Acid (PPA) affects fetal development, resulting in autism.
Personally I would not be surprised to see chemical additives to food have a wide range of effects on fetal and child development, including allergies and obesity.
I've said this since I discovered that I have an allergic reaction to Hershey's powdered chocolate milk mix but not to Nestles' powdered chocolate milk mix. Additives to extend shelf life or to prevent clumping are not listed.
Enjoy

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Replies to this message:
 Message 2 by Diomedes, posted 07-01-2019 11:00 AM RAZD has replied

  
RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


(1)
Message 4 of 9 (856541)
07-01-2019 3:03 PM
Reply to: Message 2 by Diomedes
07-01-2019 11:00 AM


Every individual is different, but the consensus appears to be that if you eat more natural foods, in their original state with minimal chemical interventions required, it appears to have the best overall effect on your health.
My diet is mostly Mediterranean based (Greek heritage) and that seemed to help quite a bit. We only used olive oil at home, mostly cooked our own meals, and avoided heavily processed foods. In adulthood, I (mostly) follow the same philosophy.
Indeed. When I was diagnosed with cancer I started on a diet to "eat more natural foods, in their original state with minimal chemical interventions required," -- local grown/raised produce, minimal pesticides (organic, non-GMO (glyphosate exposure linked to Non-Hodgkins Lymphoma)), etc. and I do believe this has helped.
Enjoy

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RebelAmerican☆Zen☯Deist
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RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 5 of 9 (856543)
07-01-2019 3:05 PM
Reply to: Message 3 by Taq
07-01-2019 12:08 PM


Re: Increased Diagnosis or Increased Prevalence?
Personally, I doubt there is a single cause of autism. Much like cancer, I suspect there will be a lot of risk factors, including genetics.
But NOT vaccinations.
Like cancer there are different types of autism.
Enjoy

we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
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This message is a reply to:
 Message 3 by Taq, posted 07-01-2019 12:08 PM Taq has replied

Replies to this message:
 Message 6 by Taq, posted 07-01-2019 3:47 PM RAZD has replied

  
RAZD
Member (Idle past 1405 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 7 of 9 (856590)
07-01-2019 6:47 PM
Reply to: Message 6 by Taq
07-01-2019 3:47 PM


Re: Increased Diagnosis or Increased Prevalence?
... Autism is developmental which is a bit more complex.
Sort of similar to the link between Lymphoma and Glyphosate (the roundup kiler)? But that's post development, just a reaction to an environmental poison.
During development it could be pollutants in food (like this Propionic acid studied here).
Development continues after birth for 10 to 20 years (depending on where you draw the line for brain development), as children consume foods contaminated with it.
Thanks.

we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
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Join the effort to solve medical problems, AIDS/HIV, Cancer and more with Team EvC! (click)

This message is a reply to:
 Message 6 by Taq, posted 07-01-2019 3:47 PM Taq has replied

Replies to this message:
 Message 9 by Taq, posted 07-02-2019 6:05 PM RAZD has seen this message but not replied

  
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