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Author Topic:   Any practical use for Universal Common Ancestor?
Taq
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Posts: 7997
Joined: 03-06-2009
Member Rating: 3.8


Message 1351 of 1359 (860329)
08-06-2019 7:32 PM
Reply to: Message 1336 by Dredge
07-30-2019 1:53 AM


Dredge writes:

An example, please.

Already given in previous posts.

quote:
Data on replacement mutations in genes of disease patients exist in a variety of online resources. In addition, genome sequencing projects and individual gene sequencing efforts have led to the identification of disease gene homologs in diverse metazoan species. The availability of these two types of information provides unique opportunities to investigate factors that are important in the development of genetically based disease by contrasting long and short-term molecular evolutionary patterns. Therefore, we conducted an analysis of disease-associated human genetic variation for seven disease genes: the cystic fibrosis transmembrane conductance regulator, glucose-6-phosphate dehydrogenase, the neural cell adhesion molecule L1, phenylalanine hydroxylase, paired box 6, the X-linked retinoschisis gene and TSC2/tuberin. Our analyses indicate that disease mutations show definite patterns when examined from an evolutionary perspective. Human replacement mutations resulting in disease are overabundant at amino acid positions most conserved throughout the long-term history of metazoans. In contrast, human polymorphic replacement mutations and silent mutations are randomly distributed across sites with respect to the level of conservation of amino acid sites within genes. Furthermore, disease-causing amino acid changes are of types usually not observed among species. Using Grantham’s chemical difference matrix, we find that amino acid changes observed in disease patients are far more radical than the variation found among species and in non-diseased humans. Overall, our results demonstrate the usefulness of evolutionary analyses for understanding patterns of human disease mutations and underscore the biomedical significance of sequence data currently being generated from various model organism genome sequencing projects.
https://academic.oup.com/hmg/article/10/21/2319/2901538

From the paper itself:

quote:
hus, as with our analysis of the frequencies of different amino acid changes, we only analyzed amino acid changes among species that could have been the result of a single nucleotide mutation and scored each type of amino acid change seen at a site once to account for the residue’s common ancestry within a phylogenetic lineage. In the cases of CFTR and TSC2, we further analyzed the observed polymorphic amino acid changes in humans. From the chemical distance scores, we used a non-parametric Kruskal–Wallace test to determine if significant overall differences existed among the sets of human and interspecific amino acid changes. Scores for CFTR and TSC2 were further subjected to Mann–Whitney U tests post hoc to determine where the significant differences lie among the disease associated, human polymorphic, and interspecific scores. This same procedure was used for comparisons of type I mutations, types II, III and IV mutations and interspecific mutation scores in G6PD. These analyses were conducted using SPSS 10.0 (SPSS Inc, 1999).

This message is a reply to:
 Message 1336 by Dredge, posted 07-30-2019 1:53 AM Dredge has responded

Replies to this message:
 Message 1356 by Dredge, posted 08-15-2019 3:58 AM Taq has not yet responded

  
Taq
Member
Posts: 7997
Joined: 03-06-2009
Member Rating: 3.8


Message 1352 of 1359 (860330)
08-06-2019 7:33 PM
Reply to: Message 1340 by Dredge
08-01-2019 9:53 PM


Dredge writes:

I asked you for an example of this (#1336) but, unsurprisingly, none was provided. It looks suspiciously like your claim is a result of some sort of delusion.

I have given the same example multiple times, and yet you ignore it. I don't think the delusion is occurring on my end.


This message is a reply to:
 Message 1340 by Dredge, posted 08-01-2019 9:53 PM Dredge has responded

Replies to this message:
 Message 1354 by Dredge, posted 08-10-2019 1:18 AM Taq has not yet responded

  
Dredge
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Posts: 1278
From: Australia
Joined: 09-06-2016
Member Rating: 1.1


Message 1353 of 1359 (860692)
08-10-2019 1:16 AM
Reply to: Message 1342 by AZPaul3
08-03-2019 12:35 AM


For one thing, it means Dobzhansky's claim that "Nothing in biology makes sense except in the light of evolution" is deluded nonsense.
This message is a reply to:
 Message 1342 by AZPaul3, posted 08-03-2019 12:35 AM AZPaul3 has responded

Replies to this message:
 Message 1355 by AZPaul3, posted 08-10-2019 9:45 AM Dredge has responded

    
Dredge
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Posts: 1278
From: Australia
Joined: 09-06-2016
Member Rating: 1.1


Message 1354 of 1359 (860693)
08-10-2019 1:18 AM
Reply to: Message 1352 by Taq
08-06-2019 7:33 PM


Edited out.

Edited by Dredge, : No reason given.


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AZPaul3
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Posts: 4380
From: Phoenix
Joined: 11-06-2006
Member Rating: 3.2


Message 1355 of 1359 (860703)
08-10-2019 9:45 AM
Reply to: Message 1353 by Dredge
08-10-2019 1:16 AM


it means Dobzhansky's claim that "Nothing in biology makes sense except in the light of evolution" is deluded nonsense.

So that's your reason for provoking this thread, so you can throw sand in some old dead guy's face?

Nothing more intellectual? No grand insights into the workings of the universe?

How does UCA lacking what you would define as practical use in applied science sever the well established connection between evolution and biology?

Do you contend that the scientific field of evolution only involves UCA? Are there no other practical links between evolution and biology?

As an example, is it your contention that mutation has no effect on biology?

Is it your contention that mutation in bacteria and viruses can never have an effect on your personal biology function?

There has got to be more to this than just you pissing on a dead guy's grave is there not?

Edited by AZPaul3, : No reason given.


Eschew obfuscation. Habituate elucidation.

This message is a reply to:
 Message 1353 by Dredge, posted 08-10-2019 1:16 AM Dredge has responded

Replies to this message:
 Message 1357 by Dredge, posted 08-15-2019 4:01 AM AZPaul3 has responded

  
Dredge
Member
Posts: 1278
From: Australia
Joined: 09-06-2016
Member Rating: 1.1


Message 1356 of 1359 (860982)
08-15-2019 3:58 AM
Reply to: Message 1351 by Taq
08-06-2019 7:32 PM


Taq writes:

Overall, our results demonstrate the usefulness of evolutionary analyses for understanding patterns of human disease mutations


Fine, but that’s not what I asked for. What you need to do is explain how common ancestry has proven useful in a practical application. For example, demonstrate how accepting the “information” that humans and chimps share a common ancestor is necessary for any practical application of biology. Your post doesn’t do that. It didn’t work the first time you offered it and … surprise, surprise … it didn’t work this time either. You appear to be a slow learner.

as with our analysis of the frequencies of different amino acid changes, we only analyzed amino acid changes among species that could have been the result of a single nucleotide mutation and scored each type of amino acid change seen at a site once to account for the residue’s common ancestry within a phylogenetic lineage.

This is not a practical use - it is merely theorising about common ancestry - completely useless speculation, in other words. Evidently, you don’t know the difference between a useless theory and a practical use.
This message is a reply to:
 Message 1351 by Taq, posted 08-06-2019 7:32 PM Taq has not yet responded

    
Dredge
Member
Posts: 1278
From: Australia
Joined: 09-06-2016
Member Rating: 1.1


Message 1357 of 1359 (860983)
08-15-2019 4:01 AM
Reply to: Message 1355 by AZPaul3
08-10-2019 9:45 AM


AZPaul3 writes:

Do you contend that the scientific field of evolution only involves UCA? Are there no other practical links between evolution and biology?
As an example, is it your contention that mutation has no effect on biology?
Is it your contention that mutation in bacteria and viruses can never have an effect on your personal biology function?


The bad news is, you have descended into a cesspit of strawmanism, extreme silliness and embarrassing fatuity. Please be advised that this display does nothing for your credibility as someone with intelligence.

The good news is, you have at least conceded that your Darwinist bedtime story is scientifically irrelevant.


This message is a reply to:
 Message 1355 by AZPaul3, posted 08-10-2019 9:45 AM AZPaul3 has responded

Replies to this message:
 Message 1358 by AZPaul3, posted 08-15-2019 6:18 AM Dredge has not yet responded

    
AZPaul3
Member
Posts: 4380
From: Phoenix
Joined: 11-06-2006
Member Rating: 3.2


Message 1358 of 1359 (860984)
08-15-2019 6:18 AM
Reply to: Message 1357 by Dredge
08-15-2019 4:01 AM


I guess you can't answer the questions because you haven't any reasons or because you don't understand the questions. Fatuity indeed.

The bad news is this is an open public forum and everyone can see you trying to avoid giving an account of your UCA foolishness.

The good news is you have another opportunity to put forward your reasoning.

How does UCA lacking what you would define as practical use in applied science sever the well established connection between evolution and biology?

Do you contend that the scientific field of evolution only involves UCA? Are there no other practical links between evolution and biology?

As an example, is it your contention that mutation has no effect on biology?

Is it your contention that mutation in bacteria and viruses can never have an effect on your personal biology function?


Eschew obfuscation. Habituate elucidation.

This message is a reply to:
 Message 1357 by Dredge, posted 08-15-2019 4:01 AM Dredge has not yet responded

  
Admin
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Message 1359 of 1359 (860985)
08-15-2019 6:25 AM


Moderator On Duty
Words used to become personal rather than address the topic will be added to the members disallowed word list.

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