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Author Topic:   Mutation
Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 35 of 171 (98351)
04-07-2004 5:13 AM
Reply to: Message 34 by SweeneyTodd
04-07-2004 4:47 AM


Re: What!?!
Just to be picky, its sickle cell anaemia.

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 Message 34 by SweeneyTodd, posted 04-07-2004 4:47 AM SweeneyTodd has replied

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Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 50 of 171 (98642)
04-08-2004 6:43 AM
Reply to: Message 46 by crashfrog
04-07-2004 9:19 PM


Tut! Tut!
Crash writes:
All mutations have the potential to do is change how protiens are created, because that's all genes do - code for protiens.
Dearie me Crash,
That is a really lamentable oversimplification of things. Even allowing for the argument that a gene is simply DNA coding for a protein there is still huge potential for mutation in the many non protein coding regulatory elements that determine where and how much of a specific protein is expressed as well as novel functions for non protein coding mRNAs such as the repressor functions of microRNAs.
TTFN,
WK
[This message has been edited by Wounded King, 04-08-2004]

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 Message 46 by crashfrog, posted 04-07-2004 9:19 PM crashfrog has replied

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 Message 51 by crashfrog, posted 04-08-2004 8:34 AM Wounded King has replied

  
Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 52 of 171 (98651)
04-08-2004 9:39 AM
Reply to: Message 51 by crashfrog
04-08-2004 8:34 AM


I'm not sure that that is neccessarily a dumb question. It is a very complicated one in many ways.
If you look at the complexity of many gene networks for producing a particular structure, say the development of the wing for arguments sake, the different individual mutations could lead to a great array of levels of deviation from Wild Type development. With a range going from total loss of a protein and thereby a whole signalling pathway to small amino acid changes leading to slightly enhanced/ decreased binding affinities.
The more connections a gene has in a particular network and the more fundamental the position of that gene/ network in subsequent developmental stages the greater the complexity of the events downstream will be, unless of course it just kills the thing stone dead and nothing ever happens again, i.e. something that interrupts initial antero-posterior patterning has farther reaching consequences than something which disrupts the identity of your individual digits.
In fact there are some papers suggesting that the more binding partners a protein has the more likely it is to have a conserved structure and other suggesting that this is not the case and highly connected proteins are just as prone to mutation. So whether the complexity of a proteins interactions affects its conservation is an ongoing topic for discussion.
I think that the complexity of consequences arising from a specific mutation is a reasonable thing to think about, as long as people realise that the answer is going to be different for almost every gene.
[This message has been edited by Wounded King, 04-08-2004]

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Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 86 of 171 (99916)
04-14-2004 9:55 AM
Reply to: Message 85 by Milagros
04-14-2004 9:48 AM


There are countless examples of naturally produced arches of rock brought about by erosion. The normal course of action is to post a picture of one as a simple illustration of this fact but I can't be bothered finding one and pasting in the relevant code. Even so I think you must recognise the existence of such structures. No human conscience is required, only the passage of time.

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