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Author Topic:   Link to Autism
RAZD
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Posts: 19977
From: the other end of the sidewalk
Joined: 03-14-2004
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(1)
Message 1 of 9 (856279)
06-29-2019 10:00 AM


quote:
Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by glia over-proliferation, neuro-inflammation, perturbed neural circuitry, and gastrointestinal symptoms. The role of gut dys-biosis in ASD is intriguing and should be elucidated. We investigated the effect of Propionic acid (PPA), a short-chain fatty acid (SCFA) and a product of dys-biotic ASD gut, on human neural stem cells (hNSCs) proliferation, differentiation and inflammation. hNSCs proliferated to 66 neuropsheres when exposed to PPA versus 45 in control. The neurosphere diameter also increased at day 10 post PPA treatment to (Mean: 193.47 um ± SEM: 6.673 um) versus (154.16 um ± 9.95 um) in control, p < 0.001. Pre-treatment with β-HB, SCFA receptor inhibitor, hindered neurosphere expansion (p < 0.001). While hNSCs spontaneously differentiated to (48.38% ± 6.08%) neurons (Tubulin-IIIβ positive) and (46.63% ± 2.5%) glia (GFAP positive), PPA treatment drastically shifted differentiation to 80% GFAP cells (p < 0.05). Following 2 mM PPA exposure, TNF-α transcription increased 4.98 fold and the cytokine increased 3.29 fold compared to control (P < 0.001). Likewise, GPR41 (PPA receptor) and pro-survival p-Akt protein were elevated (p < 0.001). PTEN (Akt inhibitor) level decreased to (0.42 ug/ul ± 0.04 ug/ul) at 2 mM PPA compared to (0.83 ug/ul ± 0.09 ug/ul) in control (p < 0.001). PPA at 2 mM decreased neurite outgrowth to (80.70 um ± 5.5 um) compared to (194.93 um ± 19.7 um) in control. Clearly, the data supports a significant role for PPA in modulating hNSC patterning leading to gliosis, disturbed neuro-circuitry, and inflammatory response as seen in ASD.


Full article follows abstract in link.

quote:
New research sheds light on a possible cause of autism: processed foods

  • A new study from the University of Central Florida makes the case for the emerging connection of autism and the human microbiome.
  • High levels of Propionic Acid (PPA), used in processed foods to extend shelf life, reduces neuronal development in fetal brains.
  • While more research is needed, this is another step in fully understanding the consequences of poor nutrition.

A new study from the University of Central Florida, published in Scientific Reports on June 19, makes the case for the emerging connection of autism and the human microbiome. High levels of Propionic Acid (PPA), which is used in processed foods to extend shelf life and inhibit the growth of mold, appears to reduce neuronal development in fetal brains.

The number of children diagnosed with ASD has been ticking up by the year, though as Silberman writes, the spectrum is not new. Still, something is changing in societies causing this surge. In 2000, the CDC observed one out of every 150 children exhibiting such behaviors; by 2018, that number climbed to one of out every 59.


So it seems that High levels of Propionic Acid (PPA) affects fetal development, resulting in autism.

Personally I would not be surprised to see chemical additives to food have a wide range of effects on fetal and child development, including allergies and obesity.

I've said this since I discovered that I have an allergic reaction to Hershey's powdered chocolate milk mix but not to Nestles' powdered chocolate milk mix. Additives to extend shelf life or to prevent clumping are not listed.

Enjoy


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Replies to this message:
 Message 2 by Diomedes, posted 07-01-2019 11:00 AM RAZD has responded

  
Diomedes
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Posts: 874
From: Central Florida, USA
Joined: 09-13-2013
Member Rating: 3.6


(2)
Message 2 of 9 (856490)
07-01-2019 11:00 AM
Reply to: Message 1 by RAZD
06-29-2019 10:00 AM


So it seems that High levels of Propionic Acid (PPA) affects fetal development, resulting in autism.

Personally I would not be surprised to see chemical additives to food have a wide range of effects on fetal and child development, including allergies and obesity.

I've said this since I discovered that I have an allergic reaction to Hershey's powdered chocolate milk mix but not to Nestles' powdered chocolate milk mix. Additives to extend shelf life or to prevent clumping are not listed.

Our Western diet has so many drawbacks, it is quite astonishing. It is almost a catch-22 at this stage. We are eating foods that make us sick and then we require medicine to alleviate the symptoms. If most individuals opted to just alter their food behaviors, it would make a world of difference to their long term health.

Every individual is different, but the consensus appears to be that if you eat more natural foods, in their original state with minimal chemical interventions required, it appears to have the best overall effect on your health.

My diet is mostly Mediterranean based (Greek heritage) and that seemed to help quite a bit. We only used olive oil at home, mostly cooked our own meals, and avoided heavily processed foods. In adulthood, I (mostly) follow the same philosophy.

I am actually often surprised how often most people (Americans especially), eat out. I make 90% of the meals I eat at home and only go out on occasion. But the mindset nowadays appears to have shifted to eat out more and eat in less. And even when people eat in, it is often pre-made meals, like TV dinners.

The good news is the younger generation appears to have taken a stronger interest in healthier foods as well more interest in the environment. So that is a plus.


This message is a reply to:
 Message 1 by RAZD, posted 06-29-2019 10:00 AM RAZD has responded

Replies to this message:
 Message 4 by RAZD, posted 07-01-2019 3:03 PM Diomedes has not yet responded

  
Taq
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Posts: 7971
Joined: 03-06-2009
Member Rating: 4.6


(1)
Message 3 of 9 (856502)
07-01-2019 12:08 PM


Increased Diagnosis or Increased Prevalence?
The big question is if autism rates are going up.

quote:

However, experts say that the increasing prevalence of ASD in the CDC’s latest report has more to do with better monitoring and diagnosis of the disorder, rather than a de facto rise in the number of children who have ASD.
https://www.healthline.com/...autism-rates-increased-again#1

Personally, I doubt there is a single cause of autism. Much like cancer, I suspect there will be a lot of risk factors, including genetics.

I would also suspect that autism was around before processed foods.


Replies to this message:
 Message 5 by RAZD, posted 07-01-2019 3:05 PM Taq has responded
 Message 8 by Sarah Bellum, posted 07-02-2019 5:35 PM Taq has not yet responded

  
RAZD
Member
Posts: 19977
From: the other end of the sidewalk
Joined: 03-14-2004
Member Rating: 3.9


(1)
Message 4 of 9 (856541)
07-01-2019 3:03 PM
Reply to: Message 2 by Diomedes
07-01-2019 11:00 AM


Every individual is different, but the consensus appears to be that if you eat more natural foods, in their original state with minimal chemical interventions required, it appears to have the best overall effect on your health.

My diet is mostly Mediterranean based (Greek heritage) and that seemed to help quite a bit. We only used olive oil at home, mostly cooked our own meals, and avoided heavily processed foods. In adulthood, I (mostly) follow the same philosophy.

Indeed. When I was diagnosed with cancer I started on a diet to "eat more natural foods, in their original state with minimal chemical interventions required," -- local grown/raised produce, minimal pesticides (organic, non-GMO (glyphosate exposure linked to Non-Hodgkins Lymphoma)), etc. and I do believe this has helped.

Enjoy


we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
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This message is a reply to:
 Message 2 by Diomedes, posted 07-01-2019 11:00 AM Diomedes has not yet responded

  
RAZD
Member
Posts: 19977
From: the other end of the sidewalk
Joined: 03-14-2004
Member Rating: 3.9


Message 5 of 9 (856543)
07-01-2019 3:05 PM
Reply to: Message 3 by Taq
07-01-2019 12:08 PM


Re: Increased Diagnosis or Increased Prevalence?
Personally, I doubt there is a single cause of autism. Much like cancer, I suspect there will be a lot of risk factors, including genetics.

But NOT vaccinations.

Like cancer there are different types of autism.

Enjoy


we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
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This message is a reply to:
 Message 3 by Taq, posted 07-01-2019 12:08 PM Taq has responded

Replies to this message:
 Message 6 by Taq, posted 07-01-2019 3:47 PM RAZD has responded

  
Taq
Member
Posts: 7971
Joined: 03-06-2009
Member Rating: 4.6


(2)
Message 6 of 9 (856550)
07-01-2019 3:47 PM
Reply to: Message 5 by RAZD
07-01-2019 3:05 PM


Re: Increased Diagnosis or Increased Prevalence?
RAZD writes:

But NOT vaccinations.

To be more specific, it isn't the thimerosal that was present in past vaccines. It may still be possible that strong immune reactions to vaccines could play a role in some rare cases.

Like cancer there are different types of autism.

I'm not sure if there are direct parallels in that sense. With cancer you are looking at mutations in cells, but not so with autism. Autism is developmental which is a bit more complex.


This message is a reply to:
 Message 5 by RAZD, posted 07-01-2019 3:05 PM RAZD has responded

Replies to this message:
 Message 7 by RAZD, posted 07-01-2019 6:47 PM Taq has responded

  
RAZD
Member
Posts: 19977
From: the other end of the sidewalk
Joined: 03-14-2004
Member Rating: 3.9


Message 7 of 9 (856590)
07-01-2019 6:47 PM
Reply to: Message 6 by Taq
07-01-2019 3:47 PM


Re: Increased Diagnosis or Increased Prevalence?
... Autism is developmental which is a bit more complex.

Sort of similar to the link between Lymphoma and Glyphosate (the roundup kiler)? But that's post development, just a reaction to an environmental poison.

During development it could be pollutants in food (like this Propionic acid studied here).

Development continues after birth for 10 to 20 years (depending on where you draw the line for brain development), as children consume foods contaminated with it.

Thanks.


we are limited in our ability to understand
by our ability to understand
RebelAmerican☆Zen☯Deist
... to learn ... to think ... to live ... to laugh ...
to share.


Join the effort to solve medical problems, AIDS/HIV, Cancer and more with Team EvC! (click)

This message is a reply to:
 Message 6 by Taq, posted 07-01-2019 3:47 PM Taq has responded

Replies to this message:
 Message 9 by Taq, posted 07-02-2019 6:05 PM RAZD has not yet responded

  
Sarah Bellum
Member
Posts: 224
Joined: 05-04-2019
Member Rating: 2.4


(1)
Message 8 of 9 (856770)
07-02-2019 5:35 PM
Reply to: Message 3 by Taq
07-01-2019 12:08 PM


Re: Increased Diagnosis or Increased Prevalence?
Consider the example of Fetal Alcohol Syndrome, instances of which have also been increasing of late.

Probably from an increase in reporting, since it's unlikely that there is more drinking during pregnancy now than in the past.


This message is a reply to:
 Message 3 by Taq, posted 07-01-2019 12:08 PM Taq has not yet responded

    
Taq
Member
Posts: 7971
Joined: 03-06-2009
Member Rating: 4.6


Message 9 of 9 (856775)
07-02-2019 6:05 PM
Reply to: Message 7 by RAZD
07-01-2019 6:47 PM


Re: Increased Diagnosis or Increased Prevalence?
RAZD writes:

During development it could be pollutants in food (like this Propionic acid studied here).

Development continues after birth for 10 to 20 years (depending on where you draw the line for brain development), as children consume foods contaminated with it.

I was under the impression that autism first showed in the first few years of life, so we can probably ignore the 10+ stage of development.

It also isn't established that propionic acid affects fetal brain development at all. The study that you linked looked at the effects of of propionic acid on cultured brain cells in a petri dish. They never looked at actual brain development. They also didn't establish that the levels of propionic acid used in the experiments are representative of levels found in the brain of mothers or infants who ingest processed foods. Next, we don't even know if the changes in the cultured cells correlates with autism.

It's an interesting paper that could be used to justify further research into propionic acid, but it is far from an actual piece of evidence for the cause of autism.


This message is a reply to:
 Message 7 by RAZD, posted 07-01-2019 6:47 PM RAZD has not yet responded

  
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