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Author Topic:   Genetic load: can someone explain?
NosyNed
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Posts: 8866
From: Canada
Joined: 04-04-2003
Member Rating: 6.5


Message 4 of 53 (488773)
11-17-2008 11:26 AM
Reply to: Message 3 by Wounded King
11-17-2008 9:33 AM


Good words, but what do they mean?
Can you explain this so even I can understand it?

This message is a reply to:
 Message 3 by Wounded King, posted 11-17-2008 9:33 AM Wounded King has responded

Replies to this message:
 Message 15 by Wounded King, posted 11-18-2008 7:12 AM NosyNed has responded

  
NosyNed
Member
Posts: 8866
From: Canada
Joined: 04-04-2003
Member Rating: 6.5


Message 16 of 53 (488829)
11-18-2008 9:26 AM
Reply to: Message 15 by Wounded King
11-18-2008 7:12 AM


Clearer good words (shorter)
Thank you. I understand all the words now and the different cases makes sense.

I would guess that the independent or synergistic effect cases are the more common?

I think I could now tie this back to the OP but I'm going out (and would rather someone else (who might get it right) did it first. (Later I will try).

Then I'll have to review the information to see the evidence for the synergistic case in humans.


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 Message 15 by Wounded King, posted 11-18-2008 7:12 AM Wounded King has not yet responded

  
NosyNed
Member
Posts: 8866
From: Canada
Joined: 04-04-2003
Member Rating: 6.5


Message 17 of 53 (488845)
11-18-2008 1:27 PM
Reply to: Message 15 by Wounded King
11-18-2008 7:12 AM


Re: Good words, but what do they mean?
From the OP:
If mutations interact multiplicatively,

So this basic assumption must be met. If they are synergistic then deleterious mutations do not pile up and become such a problem. That is the average fitness does not drop to as low as 0.05.

Right?

However, I know realize that I don't know how "average fitness" is determined or what it means. It seems to suggest that if it is 0.5 then half of offspring survive to reproduce. That makes some kind of sense.

Now then how do we decide if it is actually synergistic?

It makes sense to me that it might be. Obviously, there will be cases where having one moderately deleterious mutation might not be enough to stop reproduction but a second one is fatal? Correct?


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