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Author Topic:   Irrefutable departure
Taq
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Posts: 10038
Joined: 03-06-2009
Member Rating: 5.3


(1)
Message 20 of 48 (545246)
02-02-2010 3:38 PM
Reply to: Message 18 by mike the wiz
02-02-2010 6:43 AM


Re: Details
This is why, to an extent, as I said in message 1, it is confusing. Not just for me, but for creationists and evolutionists. As much as both sides want to believe they have the rational-cookie, in my experience, only the complete detachment of bias in one's mind, works in favour of cogent, coherent, workable logic.
Evolution can be pragmatically (i.e. workable logic) applied to biology. For instance, using the predictions from the theory of evolution you can predict protein function from DNA sequence with 96% accuracy (a large improvement over other techniques).
quote:
PLoS Comput Biol. 2005 Oct;1(5):e45. Epub 2005 Oct 7.
Protein molecular function prediction by Bayesian phylogenomics.
Engelhardt BE, Jordan MI, Muratore KE, Brenner SE.
Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California, United States of America. bee@cs.berkeley.edu
We present a statistical graphical model to infer specific molecular function for unannotated protein sequences using homology. Based on phylogenomic principles, SIFTER (Statistical Inference of Function Through Evolutionary Relationships) accurately predicts molecular function for members of a protein family given a reconciled phylogeny and available function annotations, even when the data are sparse or noisy. Our method produced specific and consistent molecular function predictions across 100 Pfam families in comparison to the Gene Ontology annotation database, BLAST, GOtcha, and Orthostrapper. We performed a more detailed exploration of functional predictions on the adenosine-5'-monophosphate/adenosine deaminase family and the lactate/malate dehydrogenase family, in the former case comparing the predictions against a gold standard set of published functional characterizations. Given function annotations for 3% of the proteins in the deaminase family, SIFTER achieves 96% accuracy in predicting molecular function for experimentally characterized proteins as reported in the literature. The accuracy of SIFTER on this dataset is a significant improvement over other currently available methods such as BLAST (75%), GeneQuiz (64%), GOtcha (89%), and Orthostrapper (11%). We also experimentally characterized the adenosine deaminase from Plasmodium falciparum, confirming SIFTER's prediction. The results illustrate the predictive power of exploiting a statistical model of function evolution in phylogenomic problems. A software implementation of SIFTER is available from the authors.
source

What are the practical applications for ID/creationism? None that I have seen.
You can say all you want about beliefs vs. beliefs, but at the end of the day the theory of evolution has real world applications that produce results.

This message is a reply to:
 Message 18 by mike the wiz, posted 02-02-2010 6:43 AM mike the wiz has not replied

  
Taq
Member
Posts: 10038
Joined: 03-06-2009
Member Rating: 5.3


Message 39 of 48 (545399)
02-03-2010 3:43 PM
Reply to: Message 25 by mike the wiz
02-03-2010 9:00 AM


If you calculate 5 x 5 and KNOW it's 25 do you doubt yourself, because people can't see it?
The difference here is that you can demonstrate it. You can take 5 groups, each with 5 apples. Put all of the apples together and count them. You can make the prediction that when the apples are counted there will be 25. If it is not 25 then you are wrong. There are 25 apples. You have just demonstrated, independent of your claim, that 5x5 is 25.
Like any good ol' boy from Missura will tell you, "SHOW ME". That is how it works. Make a risky prediction and then test that prediction.

This message is a reply to:
 Message 25 by mike the wiz, posted 02-03-2010 9:00 AM mike the wiz has not replied

  
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